Cited by 2,344Ion channel regulation and functionCardiac electrophysiology and arrhythmiasIon Channels and Receptors

The DOI matches its Crossref record; 225 of the 226 references it cites were found in a registry or an index.

Structure and Regulation of Voltage-Gated Ca 2+ Channels

Catterall, William A.·2000·Annual Review of Cell and Developmental Biology

Open this paper in CoChat — free account

Abstract

▪ Abstract Voltage-gated Ca 2+ channels mediate Ca 2+ entry into cells in response to membrane depolarization. Electrophysiological studies reveal different Ca 2+ currents designated L-, N-, P-, Q-, R-, and T-type. The high-voltage-activated Ca 2+ channels that have been characterized biochemically are complexes of a pore-forming α 1 subunit of ∼190–250 kDa; a transmembrane, disulfide-linked complex of α 2 and δ subunits; an intracellular β subunit; and in some cases a transmembrane γ subunit. Ten α 1 subunits, four α 2 δ complexes, four β subunits, and two γ subunits are known. The Ca v 1 family of α 1 subunits conduct L-type Ca 2+ currents, which initiate muscle contraction, endocrine secretion, and gene transcription, and are regulated primarily by second messenger-activated protein phosphorylation pathways. The Ca v 2 family of α 1 subunits conduct N-type, P/Q-type, and R-type Ca 2+ currents, which initiate rapid synaptic transmission and are regulated primarily by direct interaction with G proteins and SNARE proteins and secondarily by protein phosphorylation. The Ca v 3 family of α 1 subunits conduct T-type Ca 2+ currents, which are activated and inactivated more rapidly and at more negative membrane potentials than other Ca 2+ current types. The distinct structures and patterns of regulation of these three families of Ca 2+ channels provide a flexible array of Ca 2+ entry pathways in response to changes in membrane potential and a range of possibilities for regulation of Ca 2+ entry by second messenger pathways and interacting proteins.

Integrity signals

Registry

Crossref · 10.1146/annurev.cellbio.16.1.521

Cites

225 of 225 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
Dzhura, I., Wu, Y., Colbran, R. J., Balser, J. R., & Anderson, M. E. (2000) · Nature Cell Biology · doi:10.1038/35004052 · Cited by 339
Retracted
Three types of neuronal calcium channel with different calcium agonist sensitivity
Nowycky, M. C., Fox, A. P., & Tsien, R. W. (1985) · Nature · doi:10.1038/316440a0 · Cited by 2,203
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Nomenclature of Voltage-Gated Sodium Channels
Goldin, A. L., Barchi, R. L., Caldwell, J. H., Hofmann, F. B., Howe, J. R., Hunter, J. C., Kallen, R. G., Mandel, G., Meisler, M. H., Berwald‐Netter, Y., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00116-1 · Cited by 1,484
Self-citation
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Primary structure of the receptor for calcium channel blockers from skeletal muscle
Tanabe, T., Takeshima, H., Mikami, A., Flockerzi, V., Takahashi, H., Kangawa, K., Kojima, M., Matsuo, H., Hirose, T., & Numa, S. (1987) · Nature · doi:10.1038/328313a0 · Cited by 1,370
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
Hess, P., Lansman, J. B., & Tsien, R. W. (1984) · Nature · doi:10.1038/311538a0 · Cited by 1,270
Calcium channel modulation by neurotransmitters, enzymes and drugs
REUTER, H. (1983) · Nature · doi:10.1038/301569a0 · Cited by 1,266
Classes Of Calcium Channels In Vertebrate Cells
Bean, B. P. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.002055 · Cited by 1,085
Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells
McDonald, T. F., Pelzer, S., Trautwein, W., & Pelzer, D. J. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.2.365 · Cited by 995

Show all 226 references

Research works printed but not linked: 8

Bean BP. 1994. β-adrenergic modulation of cardiac calcium channel gating. In Ion Channels in the Cardiovacular System; Function and Dysfunction , ed. PM Spooner, AM Brown, WA Catterall, GJ Kaczorowski, HC Strauss, pp. 237–52. New York: Futura. 580 pp.
Fleming NW, 1993, J. Pharmacol. Exp. Ther., 265, 1199
Kernell D, 1983, Exp. Brain Res., 50, 220
Kwan YW, 1997, Can. J. Cardiol., 13, 1202
Nilius B, 1986, Biomed. Biochem. Acta, 45, 795
Oz M, 1991, J. Pharmacol. Exp. Ther., 257, 575
Rubin CS, 1994, Biochim. Biophys. Acta, 1224, 467
Tobi D, 1999, Recept. Channels, 6, 89

Sorted by citations

Items 101–200 of 1,004

PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane
Viard, P., Butcher, A. J., Halet, G., Davies, A., Nürnberg, B., Heblich, F., & DOLPHIN, A. C. (2004) · Nature Neuroscience · doi:10.1038/nn1300 · Cited by 241
Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2
Wu, L., Bauer, C. S., Zhen, X.-G., Xie, C., & Yang, J. (2002) · Nature · doi:10.1038/nature01118 · Cited by 242
The Expanding Roles of Gβγ Subunits in G Protein–Coupled Receptor Signaling and Drug Action
Khan, S. M., Sleno, R., Gora, S., Zylbergold, P., Laverdure, J., Labbé, J.-C., Miller, G. J., & Hébert, T. E. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005603 · Cited by 235
Sarcoplasmic reticulum: The dynamic calcium governor of muscle
Rossi, A. E., & Dirksen, R. T. (2006) · Muscle & Nerve · doi:10.1002/mus.20512 · Cited by 235
Synaptic transmission at retinal ribbon synapses
Heidelberger, R., Thoreson, W. B., & Witkovsky, P. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2005.04.002 · Cited by 239
Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock
Pennartz, C. M. A., de Jeu, M. T. G., Bos, N. P. A., Schaap, J., & Geurtsen, A. M. S. (2002) · Nature · doi:10.1038/nature728 · Cited by 234
Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia
Imbrici, P. (2004) · Brain · doi:10.1093/brain/awh301 · Cited by 234
GABAB Receptor Coupling to G-proteins and Ion Channels
Padgett, C. L., & Slesinger, P. A. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)58006-2 · Cited by 241
Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses
Zhang, J.-C., Lau, P.-M., & Bi, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900546106 · Cited by 241
The α 2 δ subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function
Davies, A., Kadurin, I., Alvarez‐Laviada, A., Douglas, L. R., Nieto‐Rostro, M., Bauer, C. S., Pratt, W. S., & DOLPHIN, A. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908735107 · Cited by 231
International Union of Pharmacology. XL. Compendium of Voltage-Gated Ion Channels: Calcium Channels
Catterall, W. A., Striessnig, J., Snutch, T. P., & Perez‐Reyes, E. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.8 · Cited by 230
Self-citation
Ion channels and signaling in the pituitary gland
Stojilkovic, S. S., Tabak, J., & Bertram, R. (2010) · Endocrine Reviews · doi:10.1210/er.2010-0005 · Cited by 229
β-Adrenergic regulation requires direct anchoring of PKA to cardiac Ca V 1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15
Hulme, J. T., Lin, T. W. ‐., Westenbroek, R. E., Scheuer, T., & Catterall, W. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135335100 · Cited by 229
Self-citation
A short history of voltage‐gated calcium channels
DOLPHIN, A. C. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706442 · Cited by 226
The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of α 2 δ subunits is key to trafficking voltage-gated Ca 2 + channels
Cantı́, C., Nieto‐Rostro, M., Foucault, I., Heblich, F., Wratten, J., Richards, M. W., Hendrich, J., Douglas, L. R., Page, K. M., Davies, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504183102 · Cited by 226
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
Xu, P., Lu, J., Li, Z., Yu, X., Chen, L., & Xu, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.134 · Cited by 226
Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy
Oudit, G. Y., Trivieri, M. G., Khaper, N., Liu, P. P., & Backx, P. H. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0029-x · Cited by 226
CaV2.1 channelopathies
Pietrobon, D. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0802-8 · Cited by 220
OSM1/SYP61: A Syntaxin Protein in Arabidopsis Controls Abscisic Acid–Mediated and Non-Abscisic Acid–Mediated Responses to Abiotic Stress
Zhu, J., Gong, Z., Zhang, C., Song, C., Damsz, B., Inan, G., Koiwa, H., Zhu, J., Hasegawa, P. M., & Bressan, R. A. (2002) · The Plant Cell · doi:10.1105/tpc.006981 · Cited by 221
Differential distribution of voltage‐gated calcium channel alpha‐2 delta (α2δ) subunit mRNA‐containing cells in the rat central nervous system and the dorsal root ganglia
Cole, R. L., Lechner, S. M., Williams, M. E., Prodanovich, P., Bleicher, L. S., Varney, M. A., & Gu, G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20693 · Cited by 218
Novel functional properties of Ca 2+ channel β subunits revealed by their expression in adult rat heart cells
Colecraft, H. M., Alseikhan, B. A., Takahashi, S. X., Chaudhuri, D., Mittman, S., Yegnasubramanian, V., Alvania, R. S., Johns, D. C., Marbán, E., & Yue, D. T. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.018515 · Cited by 218
The Wellcome Prize Lecture
Parekh, A. B. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034140 · Cited by 214
Alteration in temporal kinetics of Ca2+ signaling and control of growth and proliferation
Lipskaia, L., & Lompré, A. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2003.11.001 · Cited by 224
Calcium Channels and Channelopathies of the Central Nervous System
Pietrobon, D. (2002) · Molecular Neurobiology · doi:10.1385/mn:25:1:031 · Cited by 217
INTEGRINS AND STRETCH ACTIVATED ION CHANNELS; PUTATIVE COMPONENTS OF FUNCTIONAL CELL SURFACE MECHANORECEPTORS IN ARTICULAR CHONDROCYTES
Mobasheri, A., Carter, S. D., Martı́n-Vasallo, P., & Shakibaei, M. (2002) · Cell Biology International · doi:10.1006/cbir.2001.0826 · Cited by 215
Familial Hemiplegic Migraine
Pietrobon, D. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.01.008 · Cited by 215
Reversal of experimental neuropathic pain by T-type calcium channel blockers
Dogrul, A. B., Gardell, L. R., Ossipov, M. H., Tulunay, C. F., Lai, J. Y., & Porreca, F. (2003) · Pain · doi:10.1016/s0304-3959(03)00177-5 · Cited by 212
Apamin-Sensitive Small Conductance Calcium-Activated Potassium Channels, through their Selective Coupling to Voltage-Gated Calcium Channels, Are Critical Determinants of the Precision, Pace, and Pattern of Action Potential Generation in Rat Subthalamic Nucleus Neurons In Vitro
Hallworth, N. E., Wilson, C. J., & Bevan, M. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07525.2003 · Cited by 210
Ca2+ signalling in plants and green algae – changing channels
Wheeler, G. L., & Brownlee, C. (2008) · Trends in Plant Science · doi:10.1016/j.tplants.2008.06.004 · Cited by 216
Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms
Verma, V., Singh, N., & Jaggi, A. S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x1201140117162802 · Cited by 219
Regulation of CaV2 calcium channels by G protein coupled receptors
Zamponi, G. W., & Currie, K. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.10.004 · Cited by 217
Photocycles of Channelrhodopsin‐2
Nikolić, K., Grossman, N., Grubb, M. S., Burrone, J., Toumazou, C., & Degenaar, P. A. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2008.00460.x · Cited by 209
Mechanisms of human inherited epilepsies
Reid, C. A., Berkovic, S. F., & Petrou, S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.016 · Cited by 207
Cholesterol reduction impairs exocytosis of synaptic vesicles
Linetti, A., Fratangeli, A., Taverna, E., Valnegri, P., Francolini, M., Cappello, V., Matteoli, M., Passafaro, M., & Rosa, P. (2010) · Journal of Cell Science · doi:10.1242/jcs.060681 · Cited by 209
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
Finlin, B. S., Crump, S. M., Satin, J., & Andres, D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2437756100 · Cited by 209
CaV2.3 calcium channels control second-phase insulin release
Jing, X., Li, D., Olofsson, C. S., Salehi, A. A., Surve, V. V., Caballero, J., Ivarsson, R., Lundquist, I., Pereverzev, A., Schneider, T., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522518 · Cited by 208
Ion channels in the RPE
WIMMERS, S., KARL, M., & STRAUSS, O. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.12.002 · Cited by 207
Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6).
Templin, C., Ghadri, J., Rougier, J., Baumer, A., Kaplan, V., Albesa, M., Sticht, H., Rauch, A., Puleo, C., Hu, D., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr076 · Cited by 196
Molecular profiling reveals synaptic release machinery in Merkel cells.
Haeberle, H., Fujiwara, M., Chuang, J. C., Medina, M., Panditrao, M. V., Bechstedt, S., Howard, J., & Lumpkin, E. (2004) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0406308101 · Cited by 179
Mechanisms of specificity in neuronal activity-regulated gene transcription
Lyons, M. R., & West, A. E. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.003 · Cited by 209
Crosstalk Between Calcium and Redox Signaling: From Molecular Mechanisms to Health Implications
Hidalgo, C., & Donoso, P. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1886 · Cited by 199
Expression of bestrophin‐1, the product of the VMD2 gene, modulates voltage‐dependent Ca 2+ channels in retinal pigment epithelial cells
Rosenthal, R., Bakall, B., Kinnick, T. R., Peachey, N. S., Cordeiro, S., Wadelius, C., Marmorstein, A. D., & Strauß, O. (2005) · The FASEB Journal · doi:10.1096/fj.05-4495fje · Cited by 196
Non-conducting functions of voltage-gated ion channels
Kaczmarek, L. K. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1988 · Cited by 195
Migraine: New Molecular Mechanisms
Pietrobon, D. (2005) · The Neuroscientist · doi:10.1177/1073858405275554 · Cited by 194
NMDA/AMPA Ratio Impacts State Transitions and Entrainment to Oscillations in a Computational Model of the Nucleus Accumbens Medium Spiny Projection Neuron
Wolf, J. A., Moyer, J. T., Lazarewicz, M. T., Contreras, D., Benoit‐Marand, M., O’Donnell, P., & Finkel, L. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2220-05.2005 · Cited by 192
Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells
Han, L., Li, Y., Tchao, J., Kaplan, A. D., Lin, B., Li, Y., Mich-Basso, J., Lis, A., Hassan, N., London, B., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu205 · Cited by 191
A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration
Singh, A. K., Tiwari, M. N., Prakash, O., & Singh, M. P. (2012) · Current Neuropharmacology · doi:10.2174/157015912799362779 · Cited by 190
Redox active calcium ion channels and cell death
Waring, P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.08.001 · Cited by 187
Voltage-Gated Calcium Channels and Idiopathic Generalized Epilepsies
Khosravani, H., & Zamponi, G. W. (2006) · Physiological Reviews · doi:10.1152/physrev.00002.2006 · Cited by 186
Presynaptic Ca2+ channels: a functional patchwork
Reid, C. A., Bekkers, J. M., & Clements, J. D. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.10.003 · Cited by 194
Beyond faithful conduction: Short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon
Bucher, D. M., & Goaillard, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.001 · Cited by 189
Molecular Cloning and Characterization of the Human Voltage-Gated Calcium Channel α2δ-4 Subunit
Qin, N., Yagel, S. K., Momplaisir, M.-L., Codd, E. E., & D’Andrea, M. R. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.485 · Cited by 186
Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer.
Ball, S. L., Powers, P. A., Shin, H., Morgans, C. W., Peachey, N. S., & Gregg, R. G. (2002) · PubMed · Cited by 186
RETRACTED: L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the β Subunit by CaMKII
Grueter, C. E., Abiria, S. A., Dzhura, I., Wu, Y., Ham, A. L., Mohler, P. J., Anderson, M. E., & Colbran, R. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.006 · Cited by 185
Retracted
Cryo-EM structures of apo and antagonist-bound human Cav3.1
Zhao, Y., Huang, G., Wu, Q., Wu, K. K., Li, R., Lei, J., Pan, X., & Yan, N. (2019) · Nature · doi:10.1038/s41586-019-1801-3 · Cited by 183
Ion-channel regulation by G proteins
Dascal, N. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00475-1 · Cited by 182
Autoinhibitory control of the Ca V 1.2 channel by its proteolytically processed distal C‐terminal domain
Hulme, J. T., Yarov-Yarovoy, V. M., Lin, T. W. ‐., Scheuer, T., & Catterall, W. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.111799 · Cited by 181
Self-citation
A Putative Two Pore Channel AtTPC1 Mediates Ca2+ Flux in Arabidopsis Leaf Cells
Furuichi, T., Cunningham, K. W., & Muto, S. (2001) · Plant and Cell Physiology · doi:10.1093/pcp/pce145 · Cited by 179
Calcium Channel α2δ Subunits: Differential Expression, Function, and Drug Binding
Klugbauer, N., Marais, E., & Hofmann, F. B. (2003) · Journal of Bioenergetics and Biomembranes · doi:10.1023/b:jobb.0000008028.41056.58 · Cited by 178
Protein Phosphatase 2A Is Associated with Class C L-type Calcium Channels (Cav1.2) and Antagonizes Channel Phosphorylation by cAMP-dependent Protein Kinase
Davare, M. A., Horne, M. C., & Hell, J. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005462200 · Cited by 177
SCN9A Mutations Define Primary Erythermalgia as a Neuropathic Disorder of Voltage Gated Sodium Channels
Drenth, J. P. H., Morsche, R. H. M. T., Guillet, G., Taı̈eb, A., Kirby, R. L., & Jansen, J. B. �. �. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23737.x · Cited by 176
Ginsenosides: Are Any of them Candidates for Drugs Acting on the Central Nervous System?
Nah, S.-Y., Kim, D., & Rhim, H. (2007) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2007.00023.x · Cited by 174
The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of Ca V 1.2 L-type calcium channels
Barrett, C. F., & Tsien, R. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710501105 · Cited by 174
KCa and Ca2+ channels: The complex thought
Guéguinou, M., Chantôme, A., Fromont, G., Bougnoux, P., Vandier, C., & Potier‐Cartereau, M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.02.019 · Cited by 173
Regulation of Presynaptic CaV2.1 Channels by Ca2+ Sensor Proteins Mediates Short-Term Synaptic Plasticity
Mochida, S., Few, A. P., Scheuer, T., & Catterall, W. A. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.036 · Cited by 174
Self-citation
Calcium Channels and Ca2+ Fluctuations in Sperm Physiology
Darszon, A., Nishigaki, T., Wood, C. D., Treviño, C. L., Felix, R., & Beltrán, C. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)43002-8 · Cited by 170
Mutation in the Auxiliary Calcium-Channel Subunit CACNA2D4 Causes Autosomal Recessive Cone Dystrophy
Wycisk, K. A., Zeitz, C., Feil, S., Wittmer, M., Forster, U., Neidhardt, J., Wissinger, B., Zrenner, E., Wilke, R. G. H., Kohl, S., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/508944 · Cited by 169
Permanently hydrophilic, piezoelectric PVDF nanofibrous scaffolds promoting unaided electromechanical stimulation on osteoblasts
Κιτσαρά, Μ., Blanquer, A., Murillo, G., Humblot, V., de Bragança, S., Nogués, C., Ibáñez, E., Estéve, J., & Barrios, L. (2019) · Nanoscale · doi:10.1039/c8nr10384d · Cited by 168
The neuronal channelopathies
Kullmann, D. M. (2002) · Brain · doi:10.1093/brain/awf130 · Cited by 168
Primary pathways of intracellular Ca2+ mobilization by nanosecond pulsed electric field
Semenov, I., Xiao, S. H., & Pakhomov, A. G. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.11.032 · Cited by 166
Are Ca2+ channels targets of praziquantel action?
Greenberg, R. (2005) · International Journal of Parasitology · doi:10.1016/j.ijpara.2004.09.004 · Cited by 164
Calcium channels in photosynthetic eukaryotes: implications for evolution of calcium‐based signalling
Verret, F., Wheeler, G. L., Taylor, A. R., Farnham, G., & Brownlee, C. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03271.x · Cited by 169
Posttranslational mechanisms of peripheral sensitization
Bhave, G. B., & Gereau, R. W. (2004) · Journal of Neurobiology · doi:10.1002/neu.20083 · Cited by 164
T‐type voltage‐gated calcium channels as targets for the development of novel pain therapies
Todorovic, S. M., & Jevtović‐Todorović, V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01256.x · Cited by 163
Transcript Scanning Reveals Novel and Extensive Splice Variations in Human L-type Voltage-gated Calcium Channel, Cav1.2 α1 Subunit
Tang, Z. Z., Liang, M. C., Lu, S., Yu, D., Yu, C. Y., Yue, D. T., & Soong, T. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407023200 · Cited by 162
Modulation of High-Voltage Activated Ca2+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate
Suh, B., Leal, K., & Hille, B. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.001 · Cited by 162
Presynaptic Ca2+ channels – integration centers for neuronal signaling pathways
Evans, R. M., & Zamponi, G. W. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.006 · Cited by 161
Identification of the Components Controlling Inactivation of Voltage-Gated Ca2+ Channels
Kim, J., Ghosh, S., Nunziato, D. A., & Pitt, G. S. (2004) · Neuron · doi:10.1016/s0896-6273(04)00081-9 · Cited by 160
Nonlinear Input-Output Functions of Motoneurons
Binder, M. D., Powers, R. K., & Heckman, C. J. (2020) · Physiology · doi:10.1152/physiol.00026.2019 · Cited by 136
The Calcium Channel α2δ-2 Subunit Partitions with CaV2.1 into Lipid Rafts in Cerebellum: Implications for Localization and Function
Davies, A., Douglas, L. R., Hendrich, J., Wratten, J., Tran-Van-Minh, A., Foucault, I., Koch, D., Pratt, W. S., Saibil, H. R., & DOLPHIN, A. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2764-06.2006 · Cited by 159
The Endogenous Redox Agent L-Cysteine Induces T-Type Ca2+ Channel-Dependent Sensitization of a Novel Subpopulation of Rat Peripheral Nociceptors
Nelson, M. T., Joksovic, P. M., Perez‐Reyes, E., & Todorovic, S. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2527-05.2005 · Cited by 160
M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK Channels
Giessel, A. J., & Sabatini, B. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.004 · Cited by 156
Redox Regulation of Sodium and Calcium Handling
Wagner, S., Rokita, A. G., Anderson, M. E., & Maier, L. S. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4818 · Cited by 157
Differential nociceptive responses in mice lacking the α1B subunit of N-type Ca2+ channels
Hatakeyama, S., Wakamori, M., Ino, M., Miyamoto, N., Takahashi, E., Yoshinaga, T., Sawada, K., Imoto, K., Tanaka, I., Yoshizawa, T., et al. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00027 · Cited by 157
Phoneutria nigriventer Venom: A Cocktail of Toxins That Affect Ion Channels
Gomez, M. V., Kalapothakis, E., Guatimosim, C., & Prado, M. A. M. (2002) · Cellular and Molecular Neurobiology · doi:10.1023/a:1021836403433 · Cited by 155
Extracellular Domains of α-Neurexins Participate in Regulating Synaptic Transmission by Selectively Affecting N- and P/Q-Type Ca2+Channels
Zhang, W., Rohlmann, A., Sargsyan, V., Aramuni, G., Hammer, R. E., Südhof, T. C., & Missler, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0497-05.2005 · Cited by 161
A Mechanism for the Direct Regulation of T-Type Calcium Channels by Ca2+/Calmodulin-Dependent Kinase II
Welsby, P. J., Wang, H., Wolfe, J. T., Colbran, R. J., Johnson, M. L., & Barrett, P. Q. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10116.2003 · Cited by 155
The Ducky Mutation in Cacna2d2 Results in Altered Purkinje Cell Morphology and Is Associated with the Expression of a Truncated α2δ-2 Protein with Abnormal Function
Brodbeck, J., Davies, A., Courtney, J., Meir, A., Balaguero, N., Cantı́, C., Moss, F. J., Page, K. M., Pratt, W. S., Hunt, S. P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109404200 · Cited by 155
Opposing roles in neurite growth control by two seven-pass transmembrane cadherins
Shima, Y., Kawaguchi, S., Kosaka, K., Nakayama, M., Hoshino, M., Nabeshima, Y., Hirano, T., & Uemura, T. (2007) · Nature Neuroscience · doi:10.1038/nn1933 · Cited by 154
Pre‐ and postsynaptic contributions of voltage‐dependent Ca 2+ channels to nociceptive transmission in rat spinal lamina I neurons
Heinke, B., Balzer, E., & Sandkühler, J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03083.x · Cited by 153
Calcium channel functions in pain processing
Park, J., & Luo, Z. D. (2010) · Channels · doi:10.4161/chan.4.6.12869 · Cited by 153
Targeted disruption of the voltage-dependent calcium channel α2/δ-1-subunit
Fuller-Bicer, G. A., Váradi, G., Koch, S. E., Ishii, M., Bódi, I., Kadeer, N., Muth, J. N., Mikala, G., Petrashevskaya, N. N., Jordan, M. A., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00122.2009 · Cited by 153
Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac Ca V 1.2 channels during β1-adrenergic regulation
Hulme, J. T., Westenbroek, R. E., Scheuer, T., & Catterall, W. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607294103 · Cited by 152
Self-citation
T-type calcium channel regulation by specific G-protein βγ subunits
Wolfe, J. T., Wang, H., Howard, J. T., Garrison, J. C., & Barrett, P. Q. (2003) · Nature · doi:10.1038/nature01772 · Cited by 152
Ca2+ Influx through L-type Ca2+ Channels Controls the Trailing Tail Contraction in Growth Factor-induced Fibroblast Cell Migration
Yang, S., & Huang, X.-Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501625200 · Cited by 152
Expression Level of the Canonical Transient Receptor Potential 3 (TRPC3) Channel Determines Its Mechanism of Activation
Vázquez, G., Wedel, B. J., Trebak, M., Bird, G. S. J., & Putney, J. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302162200 · Cited by 150
Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin-angiotensin inhibition in hypertensive patients with chronic renal disease
Fujita, T., Ando, K., Nishimura, H., Ideura, T., Yasuda, G., Isshiki, M., & Takahashi, K. (2007) · Kidney International · doi:10.1038/sj.ki.5002623 · Cited by 151
Calcium Channels and Short-term Synaptic Plasticity
Catterall, W. A., Leal, K., & Nanou, E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.411645 · Cited by 153
Self-citation
Vascular calcium channels and high blood pressure: Pathophysiology and therapeutic implications
Sonkusare, S. K., Palade, P., Marsh, J. D., Télémaque, S., Pesic, A., & Rusch, N. J. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2005.10.005 · Cited by 150
Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice
Leroy, J., Richter, W., Mika, D., Castro, L. R., Abi‐Gerges, A., Xie, M., Scheitrum, C., Lefebvre, F., Schittl, J., Matéo, P., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44747 · Cited by 149
Self-citation

Authors: Catterall, W. A.
Affiliations: University of Washington (US)
Corresponding author: Catterall, William A.
ORCID: Catterall, William A.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2000-11
Volume: 16
Issue: 1
Pages: 521-555
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.16.1.521
OpenAlex: W2112520390
Cited by: 2,344
References: 226
Citations by year: 2026: 20 · 2025: 24 · 2024: 38 · 2023: 37 · 2022: 60 · 2021: 47 · 2020: 90 · 2019: 57 · 2018: 55 · 2017: 71 · 2016: 65 · 2015: 72 · 2014: 122 · 2013: 123 · 2012: 134
FWCI: 5.88
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: voltage-gated calcium channels, calcium channel subunits, L-type calcium current, N-type calcium current, T-type calcium current, alpha1 subunit, alpha2delta subunit, beta subunit, gamma subunit, protein phosphorylation, second messenger signaling, G protein coupling, SNARE proteins, synaptic transmission, calcium influx
MeSH terms: Animals, Calcium, Electrophysiology, Humans, Intracellular Fluid, Phosphorylation, Proteins, Calcium Channels, GTP-Binding Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Structure and Regulation of Voltage-Gated Ca 2+ Channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks