The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cadherins as Modulators of Cellular Phenotype
Abstract
▪ Abstract Cadherins are transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion. The cadherin family is large and diverse, and proteins are considered to be members of this family if they have one or more cadherin repeats in their extracellular domain. Cadherin family members are the transmembrane components of a number of cellular junctions, including adherens junctions, desmosomes, cardiac junctions, endothelial junctions, and synaptic junctions. Cadherin function is critical in normal development, and alterations in cadherin function have been implicated in tumorigenesis. The strength of cadherin interactions can be regulated by a number of proteins, including the catenins, which serve to link the cadherin to the cytoskeleton. Cadherins have been implicated in a number of signaling pathways that regulate cellular behavior, and it is becoming increasingly clear that integration of information received from cell-cell signaling, cell-matrix signaling, and growth factor signaling determines ultimate cellular phenotype and behavior.
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Citations
Cites
E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
Larue, L., Ohsugi, M., Hirchenhain, J., & Kemler, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8263 · Cited by 930
Structural basis of calcium-induced E-cadherin rigidification and dimerization
Nagar, B., Overduin, M., Ikura, M., & Rini, J. M. (1996) · Nature · doi:10.1038/380360a0 · Cited by 684
Steinberg, M. S., & Takeichi, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.206 · Cited by 572
Cited by
TGF-β-induced epithelial to mesenchymal transition
Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804
Focal adhesion kinase: in command and control of cell motility.
Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,335
Klaassen, I., Van Noorden, C. J. F., & Schlingemann, R. O. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.02.001 · Cited by 722
Calcium Pumps in Health and Disease
Brini, M., & Carafoli, E. (2009) · Physiological Reviews · doi:10.1152/physrev.00032.2008 · Cited by 676
Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
Dhawan, P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24543 · Cited by 566
Metadata
- Authors
- Wheelock, M. J., & Johnson, K. R.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2003-11
- Volume
- 19
- Issue
- 1
- Pages
- 207-235
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2143759076
- Cited by
- 672
- References
- 3
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wheelock, M. J., & Johnson, K. R. (2003). Cadherins as Modulators of Cellular Phenotype. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.19.011102.111135
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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