The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
ASYMMETRIC CELL DIVISION IN C. ELEGANS: Cortical Polarity and Spindle Positioning
Abstract
▪ Abstract The one-cell Caenorhabditis elegans embryo divides asymmetrically into a larger and smaller blastomere, each with a different fate. How does such asymmetry arise? The sperm-supplied centrosome establishes an axis of polarity in the embryo that is transduced into the establishment of anterior and posterior cortical domains. These cortical domains define the polarity of the embryo, acting upstream of the PAR proteins. The PAR proteins, in turn, determine the subsequent segregation of fate determinants and the plane of cell division. We address how cortical asymmetry could be established, relying on data from C. elegans and other polarized cells, as well as from applicable models. We discuss how cortical polarity influences spindle position to accomplish an asymmetric division, presenting the current models of spindle orientation and anaphase spindle displacement. We focus on asymmetric cell division as a function of the actin and microtubule cytoskeletons, emphasizing the cell biology of polarity.
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Cites
Benton, R., & Johnston, D. S. (2003) · Cell · doi:10.1016/s0092-8674(03)00938-3 · Cited by 410
Macara, I. G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1332 · Cited by 341
Cited by
Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998
Epidermal Stem Cells of the Skin
Blanpain, C., & Fuchs, E. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 849
Basto, R., Lau, J., Vinogradova, T., Gardiol, A., Woods, C. G., Khodjakov, A., & Raff, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.05.025 · Cited by 686
Neuronal polarity: from extracellular signals to intracellular mechanisms.
Arimura, N., & Kaibuchi, K. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2056 · Cited by 655
Metadata
- Authors
- Cowan, C. R., & Hyman, A. A.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2004-11-01
- Volume
- 20
- Issue
- 1
- Pages
- 427-453
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2162611989
- Cited by
- 226
- References
- 2
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: ASYMMETRIC CELL DIVISION IN C. ELEGANS: Cortical Polarity and Spindle Positioning. https://app.cochat.ai/papers/10.1146/annurev.cellbio.19.111301.113823
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- Cowan, C. R., & Hyman, A. A. (2004). ASYMMETRIC CELL DIVISION IN C. ELEGANS: Cortical Polarity and Spindle Positioning. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.19.111301.113823
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
