The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Genomic Imprinting: Intricacies of Epigenetic Regulation in Clusters
Abstract
▪ Abstract An intriguing characteristic of imprinted genes is that they often cluster in large chromosomal domains, raising the possibility that gene-specific and domain-specific mechanisms regulate imprinting. Several common features emerged from comparative analysis of four imprinted domains in mice and humans: (a) Certain genes appear to be imprinted by secondary events, possibly indicating a lack of gene-specific imprinting marks; (b) some genes appear to resist silencing, predicting the presence of cis-elements that oppose domain-specific imprinting control; (c) the nature of the imprinting mark remains incompletely understood. In addition, common silencing mechanisms are employed by the various imprinting domains, including silencer elements that nucleate and propagate a silent chromatin state, insulator elements that prevent promoter-enhancer interactions when hypomethylated on one parental allele, and antisense RNAs that function in silencing the overlapping sense gene and more distantly located genes. These commonalities are reminiscent of the behavior of genes subjected to, and the mechanisms employed in, dosage compensation.
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Cites
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
Bell, A. C., & Felsenfeld, G. (2000) · Nature · doi:10.1038/35013100 · Cited by 1,746
Genome Organization, Function, and Imprinting in Prader-Willi and Angelman Syndromes
Nicholls, R. D., & Knepper, J. L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.153 · Cited by 625
Buiting, K., Groß, S., Lich, C., Gillessen-Kaesbach, G., El-Maarri, O., & Horsthemke, B. (2003) · The American Journal of Human Genetics · doi:10.1086/367926 · Cited by 372
CTCF maintains differential methylation at the Igf2/H19 locus
Schoenherr, C. J., Levorse, J. M., & Tilghman, S. M. (2003) · Nature Genetics · doi:10.1038/ng1057 · Cited by 320
Imprinted methylation and its effect on expression of the mouse Zfp127 gene
Hershko, A., Razin, A., & Shemer, R. (1999) · Gene · doi:10.1016/s0378-1119(99)00192-4 · Cited by 25
Cited by
Stability and flexibility of epigenetic gene regulation in mammalian development
Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963
Fan, Y., Nikitina, T., Zhao, J., Fleury, T. J., Bhattacharyya, R., Bouhassira, E. E., Stein, A., Woodcock, C. L., & Skoultchi, A. I. (2005) · Cell · doi:10.1016/j.cell.2005.10.028 · Cited by 572
Murrell, A., Heeson, S., & Reik, W. (2004) · Nature Genetics · doi:10.1038/ng1402 · Cited by 556
A Large Imprinted microRNA Gene Cluster at the Mouse Dlk1-Gtl2 Domain
Seitz, H., Royo, H., Bortolin, M.-L., Lin, S.-P., Ferguson-Smith, A. C., & Cavaillé, J. (2004) · Genome Research · doi:10.1101/gr.2743304 · Cited by 515
Kurukuti, S., Tiwari, V. K., Tavoosidana, G., Pugacheva, E., Murrell, A., Zhao, Z., Lobanenkov, V., Reik, W., & Ohlsson, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600326103 · Cited by 511
Metadata
- Authors
- Verona, R. I., Mann, M. R. W., & Bartolomei, M. S.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2003-11
- Volume
- 19
- Issue
- 1
- Pages
- 237-259
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2107403386
- Cited by
- 275
- References
- 5
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Verona, R. I., Mann, M. R. W., & Bartolomei, M. S. (2003). Genomic Imprinting: Intricacies of Epigenetic Regulation in Clusters. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.19.111401.092717
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