Cited by 25Genetic Syndromes and ImprintingEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

Imprinted methylation and its effect on expression of the mouse Zfp127 gene

Hershko, A, Razin, A, Shemer, R·1999·Gene

Abstract

The Zfp127 gene is located on mouse chromosome 7 in an imprinted region that is homologous to the 2-Mb Prader-Willi and Angelman Syndromes region on human chromosome 15q11-q13. Here, we show that the gene is differentially methylated, the maternal allele being methylated and the paternal allele being unmethylated. This maternal methylation is established promptly after fertilization prior to syngamy. We also provide data that demonstrate the significance of methylation in the paternal expression of the gene. The expression of the Zfp127 gene in methyltransferase-deficient mice is significantly higher, suggesting that the gene is biallelically expressed in these mice. The data presented here will help to understand the mechanism by which the monoallelic expression of the entire 2-Mb Prader-Willi and Angelman Syndrome region is regulated.

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Crossref · 10.1016/s0378-1119(99)00192-4

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13 of 13 references verified0 citation errors · 0 not checkable

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  • The maternal MKRN3 allele is imprinted and only the paternal allele is expressed.

    “The maternal MKRN3 allele is imprinted and only the paternal allele is expressed.68–70”

    From Pubertal development and regulation (2016) · cites this paper as [70]

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Authors
Hershko, A., Razin, A., & Shemer, R.
Affiliations
Hebrew University of Jerusalem (IL)
Corresponding author
Shemer, R
Venue
Gene
Publisher
Elsevier BV
Published
1999-07
Volume
234
Issue
2
Pages
323-327
ISSN
0378-1119 (ISSN-L)
OpenAlex
W2114722116
Cited by
25
References
13
Citations by year
2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
0.18
Type
journal article
Language
en
Open access
closed
Locations
  • Gene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
genomic imprinting, DNA methylation, monoallelic expression, Prader-Willi syndrome, Angelman syndrome, chromosome 7, chromosome 15q11-q13, paternal allele expression, gene expression regulation
MeSH terms
Alleles, Animals, DNA, Female, Gene Expression Regulation, Genes, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Ribonucleoproteins, Genomic Imprinting, DNA Methylation, Ubiquitin-Protein Ligases, Mice

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