The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Transcriptional Control of Wound Repair
Abstract
Injury to the skin initiates a complex process of events involving inflammation as well as the formation and remodeling of new tissue. These processes result in at least partial reconstitution of the injured skin. However, wounds in adult mammals heal with a scar, which is accompanied by functional and aesthetic impairments. In addition to this problem, a large number of patients, in particular in the aged population, suffer from chronic, nonhealing ulcers. Therefore, there is a strong need to improve the wound healing process. This requires a thorough understanding of the underlying molecular and cellular mechanisms. During the past several years, important regulators of the wound healing process have been identified. In particular, the growth factors and matrix proteins, which orchestrate skin repair, have been characterized in detail. By contrast, much less is known about the transcription factors, which regulate gene expression at the wound site. This review summarizes recent data on the expression of transcription factors in skin wounds and their functions in the repair process.
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Cites
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Molecular Pathogenesis of Chronic Wounds
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Cited by
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Self-citationTransition from inflammation to proliferation: a critical step during wound healing
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Oxidative stress in normal and impaired wound repair
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Metadata
- Authors
- Schäfer, M., & Werner, S.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2007-11-01
- Volume
- 23
- Issue
- 1
- Pages
- 69-92
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2133632488
- Cited by
- 189
- References
- 24
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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