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Cited by 1,068Estrogen and related hormone effectsGenomics and Chromatin DynamicsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival

Open access
Reichardt, Holger M, Kaestner, Klaus H, Tuckermann, Jan, Kretz, Oliver, Wessely, Oliver, Bock, Rudolf, Gass, Peter, Schmid, Wolfgang, Herrlich, Peter, Angel, Peter, Schütz, Günther·1998·Cell
DOI 10.1016/s0092-8674(00)81183-6
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Abstract

Transcriptional regulation by the glucocorticoid receptor (GR) is essential for survival. Since the GR can influence transcription both through DNA-binding-dependent and -independent mechanisms, we attempted to assess their relative importance in vivo. In order to separate these modes of action, we introduced the point mutation A458T into the GR by gene targeting using the Cre/loxP system. This mutation impairs dimerization and therefore GRE-dependent transactivation while functions that require cross-talk with other transcription factors, such as transrepression of AP-1-driven genes, remain intact. In contrast to GR-/- mice, these mutants termed GRdim are viable, revealing the in vivo relevance of DNA-binding-independent activities of the GR.

Overview

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Crossref · 10.1016/s0092-8674(00)81183-6

Cites

55 of 55 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • In GRdim mice, NF-kappaB and AP-1 target genes can still be silenced by GCs.

    “Contrastingly, other findings indicate that in GRdim mice NF-κB and AP-1 target genes can still be silenced by GCs (107, 108), that the GC-inducible gene MKP-1 is normally expressed in macrophages (82) and that irritant dermatitis can successfully be treated with GCs (22).”

    From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [107]

  • Initial evidence suggested that classic transactivation by GRs was defective in GRdim mice and that this mechanism was required for the full range of GC immunosuppressive actions.

    “Initial evidence suggested that classic transactivation by GRs was defective in these mice and that this mechanism was required for the full range of GC immunosuppressive actions (107, 108).”

    From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [107]

Citations

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Research works printed but not linked: 3

  1. Caldenhoven, 1995, Negative cross-talk between RelA and the glucocorticoid receptor, Mol. Endocrinol., 9, 401
  2. Chang, 1993, Inhibition of mouse GATA-1 function by the glucocorticoid receptor, Mol. Endocrinol., 7, 528
  3. Miner, 1991, Joints in the regulatory lattice, Cell Growth Differ., 2, 525

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Metadata

Authors
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., & Schütz, G.
Affiliations
  • German Cancer Research Center (DE)
  • Saarland University (DE)
Corresponding author
Schütz, Günther
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
1998-05
Volume
93
Issue
4
Pages
531-541
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/s0092-8674(00)81183-6
OpenAlex
W1997510672
Cited by
1,068
References
54
Citations by year
2026: 2 · 2025: 11 · 2024: 7 · 2023: 16 · 2022: 21 · 2021: 22 · 2020: 21 · 2019: 28 · 2018: 24 · 2017: 26 · 2016: 18 · 2015: 24 · 2014: 40 · 2013: 36 · 2012: 34
FWCI
38.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
glucocorticoid receptor, DNA binding, receptor dimerization, gene targeting, Cre-loxP system, transcriptional regulation, survival
MeSH terms
Amino Acid Sequence, Animals, Cells, Cultured, Dexamethasone, DNA, Feedback, Gene Expression Regulation, Glucocorticoids, Hypothalamo-Hypophyseal System, Molecular Sequence Data, Pituitary-Adrenal System, Protein Binding, Receptors, Glucocorticoid, T-Lymphocytes, Transcription, Genetic, Erythroid Precursor Cells, Apoptosis, Point Mutation, Mice, Knockout, Mice

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