The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
HETEROCHROMATIN AND GENE EXPRESSION IN DROSOPHILA
Abstract
Heterochromatin is both necessary for the expression of heterochromatic genes and inhibitory for the expression of euchromatic genes. These two properties of heterochromatin have been elucidated from the study of chromosome rearrangements that induce position effect variegation (PEV) in Drosophila melanogaster. Novel euchromatin-heterochromatin junctions can affect the expression of euchromatic and heterochromatic genes located several megabases away, distinguishing higher order chromatin structure from most other regulatory mechanisms. Studies of PEV promise insights into the basis for heterochromatin formation and the role of higher order chromatin and chromosome structure in gene regulation. We evaluate the models and experimental data that address the mechanisms of PEV in different cell types, the potential functions of modifiers of PEV, and the relationship of PEV to other phenomena associated with variegated gene expression in Drosophila.
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Cites
Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila
Dorer, D. (1994) · Cell · doi:10.1016/0092-8674(94)90439-1 · Cited by 506
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FUNCTIONAL ELEMENTS IN DROSOPHILA MELANOGASTER HETEROCHROMATIN
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Cited by
Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263
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Safe harbours for the integration of new DNA in the human genome
Sadelain, M., Papapetrou, E. P., & Bushman, F. D. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3179 · Cited by 441
Nielsen, A. L., Ortiz, J. A., You, J., Oulad‐Abdelghani, M., Khechumian, R., Gansmuller, A., Chambon, P., & Losson, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6385 · Cited by 361
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Metadata
- Authors
- Weiler, K. S., & Wakimoto, B. T.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 1995-12
- Volume
- 29
- Issue
- 1
- Pages
- 577-605
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2136392800
- Cited by
- 533
- References
- 28
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weiler, K. S., & Wakimoto, B. T. (1995). HETEROCHROMATIN AND GENE EXPRESSION IN DROSOPHILA. Annual Review of Genetics. https://doi.org/10.1146/annurev.ge.29.120195.003045
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
