The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works

DNA sequencing with chain-terminating inhibitors

Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572 · see citing works

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512 · see citing works

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719 · see citing works

Antibodies, a laboratory manual

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318 · see citing works

Efficient<i>in vitro</i>synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

Melton, D. A., Krieg, P. A., Rebagliati, M. R., Maniatis, T., Zinn, K., & Green, M. R. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7035 · Cited by 6,324 · see citing works

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

Wahl, G. M., Stern, M., & Stark, G. R. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3683 · Cited by 3,351 · see citing works

Genetic Transformation of Drosophila with Transposable Element Vectors

Rubin, G. M., & Spradling, A. C. (1982) · Science · doi:10.1126/science.6289436 · Cited by 3,024 · see citing works

Genetic variations of Drosophila melanogaster.

Lindsley, D. L., & Grell, E. H. (1968) · Biodiversity Heritage Library (Smithsonian Institution) · doi:10.5281/zenodo.10755360 · Cited by 2,623 · see citing works

Drosophila: A laboratory handbook

Ashburner, M. (1990) · Trends in Ecology & Evolution · doi:10.1016/0169-5347(90)90121-s · Cited by 1,703 · see citing works

Analysis of P transposable element functions in drosophila

Karess, R. E., & Rubin, G. M. (1984) · Cell · doi:10.1016/0092-8674(84)90534-8 · Cited by 731 · see citing works

Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene.

James, T. C., & Elgin, S. C. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.3862 · Cited by 643 · see citing works

Functional cDNA libraries from Drosophila embryos

Brown, N. H., & Kafatos, F. C. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90010-1 · Cited by 602 · see citing works

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

Eissenberg, J. C., James, T. C., Foster-Hartnett, D. M., Hartnett, T., Ngan, V, & Elgin, S. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9923 · Cited by 588 · see citing works

The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

Paro, R., & Hogness, D. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.263 · Cited by 562 · see citing works

Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila.

James, T. C., Eissenberg, J. C., Craig, C., Dietrich, Hobson, A., & Elgin, S. C. R. (1989) · PubMed · Cited by 407 · see citing works

Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect.

LOCKE, J. L., Kotarski, M. A., & Tartof, K. D. (1988) · Genetics · doi:10.1093/genetics/120.1.181 · Cited by 313 · see citing works

In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster

Zink, B., & Paro, R. (1989) · Nature · doi:10.1038/337468a0 · Cited by 304 · see citing works

A transposable P vector that confers selectable G418 resistance to Drosophila larvae

Steller, H., & Pirrotta, V. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb02332.x · Cited by 286 · see citing works

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

Reuter, G., Giarrè, M., Farah, J. A., Gausz, J., Spierer, A., & Spierer, P. (1990) · Nature · doi:10.1038/344219a0 · Cited by 223 · see citing works

The genetics of position — effect variegation modifying loci inDrosophila melanogaster

Wustmann, G., Szidonya, J., Taubert, H., & Reuter, G. (1989) · Molecular and General Genetics MGG · doi:10.1007/bf02464926 · Cited by 169 · see citing works

Molecular organization of a Drosophila puff site that responds to ecdysone

Meyerowitz, E. M., & Hogness, D. S. (1982) · Cell · doi:10.1016/0092-8674(82)90386-5 · Cited by 166 · see citing works

Isolation of dominant suppressor mutations for position-effect variegation in Drosophila melanogaster

Reuter, G., & Wolff, I. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00293947 · Cited by 137 · see citing works

Position effect variegation in Drosophila: Towards a genetics of chromatin assembly

Eissenberg, J. C. (1989) · BioEssays · doi:10.1002/bies.950110105 · Cited by 131 · see citing works

KGB: a single buffer for all restriction endonucleases

McClelland, M., Hanish, J., Nelson, M. B., & Patel, Y. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.1.364 · Cited by 128 · see citing works

Genes which suppress position-effect variegation in Drosophila melanogaster are clustered

Sinclair, D. A. R., Mottus, R. C., & Grigliatti, T. A. (1983) · Molecular and General Genetics MGG · doi:10.1007/bf00334834 · Cited by 127 · see citing works

STUDIES OF EYE PIGMENTS OF DROSOPHILA. I. METHODS OF EXTRACTION AND QUANTITATIVE ESTIMATION OF THE PIGMENT COMPONENTS

Ephrussi, B., & Herold, J. L. (1944) · Genetics · doi:10.1093/genetics/29.2.148 · Cited by 119 · see citing works

Mutations in polycombeotic, a Drosophila polycomb-group gene, cause a wide range of maternal and zygotic phenotypes.

Phillips, M., & Shearn, A. (1990) · Genetics · doi:10.1093/genetics/125.1.91 · Cited by 111 · see citing works

Genetic Control of Body Segment Differentiation in Drosophila

Duncan, I., & Lewis, E. B. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6345-9_11 · Cited by 91 · see citing works

Position-effect variegation and chromosome structure of a heat shock puff in Drosophila

Henikoff, S. (1981) · Chromosoma · doi:10.1007/bf00327360 · Cited by 75 · see citing works

ON BIOLOGICAL FUNCTIONS MAPPING TO THE HETEROCHROMATIN OF DROSOPHILA MELANOGASTER

Pimpinelli, S., Sullivan, W., Prout, M., & Sandler, L. (1985) · Genetics · doi:10.1093/genetics/109.4.701 · Cited by 75 · see citing works

Mutants affecting position-effect heterochromatinization in Drosophila melanogaster

Reuter, G., Werner, W., & Hoffmann, H. J. (1982) · Chromosoma · doi:10.1007/bf00327349 · Cited by 74 · see citing works

EVIDENCE FOR A SET OF CLOSELY LINKED AUTOSOMAL GENES THAT INTERACT WITH SEX-CHROMOSOME HETEROCHROMATIN IN DROSOPHILA MELANOGASTER

Sandler, L. (1977) · Genetics · doi:10.1093/genetics/86.3.567 · Cited by 60 · see citing works

Mechanisms for the construction and developmental control of heterochromatin formation and imprinted chromosome domains

Tartof, K. D., & Bremer, M. (1990) · Development · doi:10.1242/dev.108.supplement.35 · Cited by 47 · see citing works

DNase I hypersensitive sites of the chromatin for Drosophila melanogaster ribosomal protein 49 gene

Wong, Y., O'Connell, P., Rosbash, M., & Elgin, S. C. R. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.24.6749 · Cited by 33 · see citing works

Variegated expression of the Sgs-4 locus in Drosophila melanogaster

Kornher, J. S., & Kauffman, S. A. (1986) · Chromosoma · doi:10.1007/bf00288495 · Cited by 25 · see citing works

Sex-specific control of Drosophila melanogaster yolk protein 1 gene expression is limited to transcription.

Kraus, K. W., Lee, Y., Lis, J. T., & Wolfner, M. F. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.11.4756 · Cited by 19 · see citing works

Regulation of chromatin structure by site-specific histone H3 methyltransferases

Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845 · see citing works

Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

Peters, A. H. F. M., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schöfer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00542-6 · Cited by 1,766 · see citing works

Central role of Drosophila SU(VAR)3–9 in histone H3‐K9 methylation and heterochromatic gene silencing

Schotta, G., Ebert, A., Krauss, V., Fischer, A., Hoffmann, J., Rea, S., Jenuwein, T., Dorn, R., & Reuter, G. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.1121 · Cited by 714 · see citing works

Histone methylation versus histone acetylation: new insights into epigenetic regulation

Rice, J. C., & Allis, C. D. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00208-8 · Cited by 701 · see citing works

The protein encoded by the Drosophila position‐effect variegation suppressor gene Su(var)3‐9 combines domains of antagonistic regulators of homeotic gene complexes.

Tschiersch, B., Hofmann, A., Krauss, V., Dorn, R., Korge, G., & Reuter, G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06693.x · Cited by 567 · see citing works

HETEROCHROMATIN AND GENE EXPRESSION IN DROSOPHILA

Weiler, K. S., & Wakimoto, B. T. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.003045 · Cited by 533 · see citing works

Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila

Elgin, S. C. R., & Reuter, G. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017780 · Cited by 499 · see citing works

Epigenetics and cancer

Lund, A. H., & van Lohuizen, M. (2004) · Genes &amp; Development · doi:10.1101/gad.1232504 · Cited by 489 · see citing works

Position effect variegation in Drosophila is associated with an altered chromatin structure.Preprint

Wallrath, L. L., & Elgin, S. C. R. (1995) · Genes & Development · doi:10.1101/gad.9.10.1263 · Cited by 465 · see citing works

The HP1 protein family: getting a grip on chromatin

Eissenberg, J. C., & Elgin, S. C. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00058-7 · Cited by 461 · see citing works

Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.Preprint

Allshire, R. C., Nimmo, E. R., Ekwall, K., Javerzat, J., & Cranston, G. (1995) · Genes & Development · doi:10.1101/gad.9.2.218 · Cited by 450 · see citing works

Functional mammalian homologues of the Drosophila PEV‐modifier Su(var)3‐9 encode centromere‐associated proteins which complex with the heterochromatin component M31

Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P. B., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1923 · Cited by 441 · see citing works

Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes

Pak, D. T. S., Pflumm, M. F., Chesnokov, I. N., Huang, D. W., Kellum, R., Marr, J., Romanowski, P., & Botchan, M. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80415-8 · Cited by 408 · see citing works

Heterochromatin: new possibilities for the inheritance of structure

Grewal, S. I. S., & Elgin, S. C. R. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00284-8 · Cited by 408 · see citing works

SET domain proteins modulate chromatin domains in eu- and heterochromatin

Jenuwein, T., Laible, G., Dorn, R., & Reuter, G. (1998) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050127 · Cited by 395 · see citing works

KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing

Ryan, R. F., Schultz, D., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J., & Rauscher, F. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4366 · Cited by 382 · see citing works

Heterochromatin Formation in Mammalian Cells

Nielsen, A. L., Oulad‐Abdelghani, M., Ortiz, J. A., Remboutsika, E., Chambon, P., & Losson, R. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00218-0 · Cited by 384 · see citing works

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegationPreprint

Ayyanathan, K., Lechner, M. S., Bell, P., Maul, G. G., Schultz, D., Yamada, Y., Tanaka, K., Torigoe, K., & Rauscher, F. J. (2003) · Genes & Development · doi:10.1101/gad.1102803 · Cited by 356 · see citing works

<i>Drosophila</i> PIWI associates with chromatin and interacts directly with HP1a

Brower-Toland, B., Findley, S. D., Jiang, L., Liu, L., Yin, H., Dus, M., Zhou, P., Elgin, S. C. R., & Lin, H. (2007) · Genes &amp; Development · doi:10.1101/gad.1564307 · Cited by 350 · see citing works

Position effect variegation at fission yeast centromeres

Allshire, R. C., Javerzat, J., Redhead, N. J., & Cranston, G. (1994) · Cell · doi:10.1016/0092-8674(94)90180-5 · Cited by 331 · see citing works

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

Sun, W., Samimi, H., Gamez, M., Zare, H., & Frost, B. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0194-1 · Cited by 315 · see citing works

Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila

Ren, X., Yang, Z., Jiang, X., Sun, J., Mao, D., Hu, Y., Yang, S., Qiao, H., Wang, X., Hu, Q., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.044 · Cited by 305 · see citing works

Environmental signals and cell fate specification in premigratory neural crest

Dorsky, R. I., Moon, R. T., & Raible, D. W. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 111 · see citing works

The Chromodomain Protein Swi6: A Key Component at Fission Yeast Centromeres

Ekwall, K., Javerzat, J., Lorentz, A., Schmidt, H., Cranston, G., & Allshire, R. C. (1995) · Science · doi:10.1126/science.7660126 · Cited by 299 · see citing works

Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors

Flueck, C., Bártfai, R., Volz, J. C., Niederwieser, I., Salcedo‐Amaya, A. M., Alako, B., Ehlgen, F., Ralph, S. A., Cowman, A. F., Bozdech, Z., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000569 · Cited by 298 · see citing works

Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells

Festenstein, R., Pagakis, S. N., Hiragami, K., Lyon, D., Verreault, A., Sekkali, B., & Kioussis, D. (2003) · Science · doi:10.1126/science.1078694 · Cited by 283 · see citing works

Mutations inLIKE HETEROCHROMATIN PROTEIN 1affect flowering time and plant architecture inArabidopsis

Gaudin, V., Libault, M., Pouteau, S., Juul, T., Zhao, G., Lefebvre, D., & Grandjean, O. (2001) · Development · doi:10.1242/dev.128.23.4847 · Cited by 285 · see citing works

Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis

Larson, K., Yan, S.-J., Tsurumi, A., Liu, J., Zhou, J., Gaur, K., Guo, D., Eickbush, T. H., & Li, W. X. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002473 · Cited by 284 · see citing works

Mammalian homologues of the Polycomb‐group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres

Laible, G., Wolf, A., Dorn, R., Reuter, G., Nislow, C., Lebersorger, A., Popkin, D., Pillus, L., & Jenuwein, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3219 · Cited by 279 · see citing works

Chromatin dynamics at DNA replication, transcription and repair

Ehrenhofer‐Murray, A. E. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04162.x · Cited by 275 · see citing works

The Heterochromatin Protein 1 Prevents Telomere Fusions in Drosophila

Fanti, L., Giovinazzo, G., Berloco, M. F., & Pimpinelli, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80152-5 · Cited by 273 · see citing works

Functional analysis of the chromo domain of HP1.

Platero, J. S., Hartnett, T., & Eissenberg, J. C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00069.x · Cited by 262 · see citing works

Dimerisation of a chromo shadow domain and distinctions from the chromodomain as revealed by structural analysis

Cowieson, N. P., Partridge, J. F., Allshire, R. C., & McLaughlin, P. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00467-x · Cited by 255 · see citing works

Specific destruction of kinetochore protein CENP‐C and disruption of cell division by herpes simplex virus immediate‐early protein Vmw110

Everett, R. D., Earnshaw, W. C., Findlay, J., & Lomonte, P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1526 · Cited by 245 · see citing works

Position-effect variegation and the new biology of heterochromatin

Karpen, G. H. (1994) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80055-3 · Cited by 235 · see citing works

HP1 Is Essential for DNA Methylation in Neurospora

Freitag, M., Hickey, P. C., Khlafallah, T. K., Read, N. D., & Selker, E. U. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00024-3 · Cited by 236 · see citing works

The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax.

Jones, R. S., & Gelbart, W. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6357 · Cited by 236 · see citing works

Heterochromatin and gene regulation in Drosophila

Elgin, S. C. R. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80050-5 · Cited by 229 · see citing works

Chromatin signatures of cancerPreprint

Morgan, M. A., & Shilatifard, A. (2015) · Genes & Development · doi:10.1101/gad.255182.114 · Cited by 214 · see citing works

Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential

Lechner, M. S., Begg, G. E., Speicher, D. W., & Rauscher, F. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6449-6465.2000 · Cited by 210 · see citing works

Structure-Function Analysis of SUV39H1 Reveals a Dominant Role in Heterochromatin Organization, Chromosome Segregation, and Mitotic Progression

Melcher, M., Schmid, M., Aagaard, L., Selenko, P., Laible, G., & Jenuwein, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3728-3741.2000 · Cited by 206 · see citing works

The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain

Lechner, M. S., Schultz, D., Negorev, D. G., Maul, G. G., & Rauscher, F. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.016 · Cited by 211 · see citing works

polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila.Preprint

Fauvarque, M., & Dura, J. (1993) · Genes & Development · doi:10.1101/gad.7.8.1508 · Cited by 198 · see citing works

The contradictory definitions of heterochromatin: transcription and silencing

Huisinga, K. L., Brower‐Toland, B. D., & Elgin, S. C. R. (2006) · Chromosoma · doi:10.1007/s00412-006-0052-x · Cited by 200 · see citing works

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

Herz, H.-M., Morgan, M., Gao, X., Jackson, J., Rickels, R., Swanson, S. K., Florens, L., Washburn, M. P., Eissenberg, J. C., & Shilatifard, A. (2014) · Science · doi:10.1126/science.1255104 · Cited by 199 · see citing works

Heterochromatin Protein 1 Is Required for the Normal Expression of Two Heterochromatin Genes in Drosophila

Lu, B. Y., Emtage, P. C. R., Duyf, B., Hilliker, A. J., & Eissenberg, J. C. (2000) · Genetics · doi:10.1093/genetics/155.2.699 · Cited by 187 · see citing works

The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin

Koonin, E. V., Zhou, S., & Lucchesi, J. C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.21.4229 · Cited by 182 · see citing works

The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatinPreprint

Swaminathan, J., Baxter, E. M., & Corces, V. G. (2005) · Genes & Development · doi:10.1101/gad.1259105 · Cited by 180 · see citing works

Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos

Kellum, R., & Alberts, B. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.4.1419 · Cited by 169 · see citing works

Structure of the chromatin binding (chromo) domain from mouse modifier protein 1

Ball, L., Murzina, N. V., Broadhurst, R. W., Raine, A. R. C., Archer, S. J., Stott, F. J., Murzin, A. G., Singh, P. B., Domaille, P. J., & Laue, E. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.9.2473 · Cited by 168 · see citing works

HP1 Controls Telomere Capping, Telomere Elongation, and Telomere Silencing by Two Different Mechanisms in Drosophila

Perrini, B., Piacentini, L., Fanti, L., Fabio Altieri, F., Chichiarelli, S., Berloco, M. F., Turano, C., Ferraro, A., & Pimpinelli, S. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.036 · Cited by 166 · see citing works

Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity

Saunders, W. S., Chue, C., Goebl, M. G., Craig, C. A., Clark, R. F., Powers, J. A., Eissenberg, J. C., Elgin, S. C. R., Rothfield, N. F., & Earnshaw, W. C. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.2.573 · Cited by 164 · see citing works

Epigenetic regulation of autosomal gene expression by sex chromosomes

Wijchers, P. J., & Festenstein, R. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.01.004 · Cited by 164 · see citing works

Degradation of Nucleosome-associated Centromeric Histone H3-like Protein CENP-A Induced by Herpes Simplex Virus Type 1 Protein ICP0

Lomonte, P., Sullivan, K. F., & Everett, R. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008547200 · Cited by 164 · see citing works

The control of gene expression and cell identity by H3K9 trimethylation

Ninova, M., Tóth, K. F., & Aravin, A. A. (2019) · Development · doi:10.1242/dev.181180 · Cited by 162 · see citing works

Repression of viral transcription during herpes simplex virus latency

Preston, C. M. (2000) · Microbiology · doi:10.1099/0022-1317-81-1-1 · Cited by 160 · see citing works

Positive Selection Drives the Evolution of rhino, a Member of the Heterochromatin Protein 1 Family in Drosophila

Vermaak, D., Henikoff, S., & Malik, H. S. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010009 · Cited by 151 · see citing works

Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles

Cryderman, D. E., Morris, E. J., Biessmann, H., Elgin, S. C. R., & Wallrath, L. L. (1999) · The EMBO Journal · doi:10.1093/emboj/18.13.3724 · Cited by 155 · see citing works

Inner nuclear membrane proteins: functions and targeting

Holmer, L. E., & Worman, H. J. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000813 · Cited by 153 · see citing works

Heterochromatin Protein 1 (HP1a) Positively Regulates Euchromatic Gene Expression through RNA Transcript Association and Interaction with hnRNPs in Drosophila

Piacentini, L., Fanti, L., Negri, R., Vescovo, V. D., Fatica, A., Fabio Altieri, F., & Pimpinelli, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000670 · Cited by 144 · see citing works

The Heterochromatin Protein 1 (HP1) Family: Put Away a Bias toward HP1

Kwon, S. H., & Workman, J. L. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)13988-4 · Cited by 142 · see citing works

Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals

Kioussis, D., & Festenstein, R. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80008-1 · Cited by 144 · see citing works

SU(VAR)3‐7, a Drosophila heterochromatin‐associated protein and companion of HP1 in the genomic silencing of position‐effect variegation

Cléard, F., Delattre, M., & Spierer, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5280 · Cited by 140 · see citing works

Sexual Dimorphism in Mammalian Autosomal Gene Regulation Is Determined Not Only by Sry but by Sex Chromosome Complement As Well

Wijchers, P. J., Yandım, C., Panousopoulou, E., Ahmad, M., Harker, N., Saveliev, A., Burgoyne, P. S., & Festenstein, R. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.08.005 · Cited by 134 · see citing works

Heterochromatin Protein 1 Binds to Nucleosomes and DNA in Vitro

Zhao, T., Heyduk, T., Allis, C. D., & Eissenberg, J. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003493200 · Cited by 132 · see citing works

Chapter 1 Chromatin Structure and the Regulation of Gene Expression: The Lessons of PEV in Drosophila

Girton, J. R., & Johansen, K. M. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00001-6 · Cited by 132 · see citing works

Linking Heterochromatin Protein 1 (HP1) to cancer progression

Dialynas, G. K., Vitalini, M. W., & Wallrath, L. L. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.09.007 · Cited by 131 · see citing works

The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity

Daubresse, G., Deuring, R., Moore, L., Papoulas, O., Zakrajsek, I., Waldrip, W. R., Scott, M. P., Kennison, J. A., & Tamkun, J. W. (1999) · Development · doi:10.1242/dev.126.6.1175 · Cited by 132 · see citing works

Heterochromatin protein 1: a pervasive controlling influence

Hiragami, K., & Festenstein, R. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5287-9 · Cited by 130 · see citing works

Long-Range Nucleosome Ordering Is Associated with Gene Silencing in Drosophila melanogaster Pericentric Heterochromatin

Sun, F.-L., Cuaycong, M. H., & Elgin, S. C. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2867-2879.2001 · Cited by 126 · see citing works

Down-regulation of HP1Hsalpha expression is associated with the metastatic phenotype in breast cancer.

Kirschmann, D. A., Lininger, R. A., Gardner, L. M., Seftor, E. A., Odero, V. A., Ainsztein, A. M., Earnshaw, W. C., Wallrath, L. L., & Hendrix, M. J. C. (2000) · PubMed · Cited by 124 · see citing works

Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context- dependent manner

Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Saveliev, A., Kioussis, D., & Singh, P. B. (1999) · Nature Genetics · doi:10.1038/70579 · Cited by 123 · see citing works

Actin-Related Proteins

Schafer, D. A., & Schroer, T. A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.341 · Cited by 123 · see citing works

Gene function beyond the single trait: natural variation, gene effects, and evolutionary ecology in Arabidopsis thaliana

Tonsor, S. J., Alonso‐Blanco, C., & Koornneef, M. (2004) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2004.01264.x · Cited by 123 · see citing works

Molecular biology of the chromo domain: an ancient chromatin module comes of age

Eissenberg, J. C. (2001) · Gene · doi:10.1016/s0378-1119(01)00628-x · Cited by 120 · see citing works

Balance between Distinct HP1 Family Proteins Controls Heterochromatin Assembly in Fission Yeast

Sadaie, M., Kawaguchi, R., Ohtani, Y., Arisaka, F., Tanaka, K., Shirahige, K., & Nakayama, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00791-08 · Cited by 113 · see citing works

Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres

Aagaard, L., Schmid, M., Warburton, P. E., & Jenuwein, T. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.5.817 · Cited by 110 · see citing works

Telomeric Trans-Silencing: An Epigenetic Repression Combining RNA Silencing and Heterochromatin Formation

Josse, T., Teysset, L., Todeschini, A., Sidor, C., Anxolabéhère, D., & Ronsseray, S. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0030158 · Cited by 109 · see citing works

Differentially expressed genes associated with the metastatic phenotype in breast cancer

Kirschmann, D. A., Seftor, E. A., Nieva, D. R. C., Mariano, E. A., & Hendrix, M. J. C. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006188129423 · Cited by 108 · see citing works

Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1

Yamamoto, K., & Sonoda, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)03021-8 · Cited by 108 · see citing works

Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers

Hwang, K.-K., Eissenberg, J. C., & Worman, H. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211303598 · Cited by 110 · see citing works

Heterochromatin Protein 1 Is Involved in Control of Telomere Elongation in Drosophila melanogaster

Savitsky, M., Кравчук, О. И., Melnikova, L. S., & Georgiev, P. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.9.3204-3218.2002 · Cited by 108 · see citing works

Polytene Chromosomes, Heterochromatin, and Position Effect Variegation

Zhimulev, I. F. (1997) · Advances in genetics · doi:10.1016/s0065-2660(08)60341-7 · Cited by 107 · see citing works

A dynamic connection between centromeres and ND10 proteins

Everett, R. D., Earnshaw, W. C., Pluta, A. F., Sternsdorf, T., Ainsztein, A. M., Carmena, M., Ruchaud, S., Hsu, W., & Orr, A. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.20.3443 · Cited by 105 · see citing works

P-Element Repression in Drosophila melanogaster by a Naturally Occurring Defective Telomeric P Copy

Marin, L., Lehmann, M., Nouaud, D., Izaabel, H., Anxolabéhère, D., & Ronsseray, S. (2000) · Genetics · doi:10.1093/genetics/155.4.1841 · Cited by 99 · see citing works

Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation

Wang, X., Pan, L., Wang, S., Zhou, J., McDowell, W., Park, J., Haug, J., Staehling‐Hampton, K., Tang, H., & Xie, T. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002426 · Cited by 96 · see citing works

Polytene Chromosomes: 70 Years of Genetic Research

Zhimulev, I. F., Belyaeva, E. S., Semeshin, V. F., Koryakov, D. E., Demakov, S. A., Demakova, O. V., Pokholkova, G. V., & Andreyeva, E. N. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)41004-3 · Cited by 100 · see citing works

Selective interaction between the chromatin‐remodeling factor BRG1 and the heterochromatin‐associated protein HP1α

Nielsen, A. L., Sanchez, C., Ichinose, H., Cerviño, M., Lerouge, T., Chambon, P., & Losson, R. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf560 · Cited by 99 · see citing works

SU(VAR)3-9 is a Conserved Key Function in Heterochromatic Gene Silencing

Schotta, G., Ebert, A., & Reuter, G. (2003) · Genetica · doi:10.1023/a:1022923508198 · Cited by 97 · see citing works

N-Terminal Phosphorylation of HP1α Promotes Its Chromatin Binding

Hiragami-Hamada, K., Shinmyozu, K., Hamada, D., Tatsu, Y., Uegaki, K., Fujiwara, S., & Nakayama, J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01012-10 · Cited by 95 · see citing works

The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites

Tie, F., Furuyama, T., & Harte, P. J. (1998) · Development · doi:10.1242/dev.125.17.3483 · Cited by 97 · see citing works

Cell differentiation induces TIF1β association with centromeric heterochromatin via an HP1 interaction

Cammas, F. M., Oulad‐Abdelghani, M., Vonesch, J., Huss-Garcia, Y., Chambon, P., & Losson, R. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.17.3439 · Cited by 96 · see citing works

Chromatin architectural proteins

McBryant, S. J., Adams, V. H., & Hansen, J. C. (2006) · Chromosome Research · doi:10.1007/s10577-006-1025-x · Cited by 95 · see citing works

Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding.

Powers, J. A., & Eissenberg, J. C. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.2.291 · Cited by 93 · see citing works

Position effect and related phenomena

Henikoff, S. (1992) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80114-5 · Cited by 91 · see citing works

Morphology and Structure of Polytene Chromosomes

Zhimulev, I. F. (1996) · Advances in genetics · doi:10.1016/s0065-2660(08)60533-7 · Cited by 88 · see citing works

Characterization of sequences associated with position-effect variegation at pericentric sites in Drosophila heterochromatin

Cryderman, D. E., Cuaycong, M. H., Elgin, S. C. R., & Wallrath, L. L. (1998) · Chromosoma · doi:10.1007/s004120050309 · Cited by 88 · see citing works

Epigenetic effects on yeast transcription caused by mutations in an actin-related protein present in the nucleus.Preprint

Jiang, Y. W., & Stillman, D. J. (1996) · Genes & Development · doi:10.1101/gad.10.5.604 · Cited by 88 · see citing works

Structural biology of the chromodomain: Form and function

Eissenberg, J. C. (2012) · Gene · doi:10.1016/j.gene.2012.01.003 · Cited by 86 · see citing works

Increased phosphorylation of HP1, a heterochromatin-associated protein of Drosophila, is correlated with heterochromatin assembly.

Eissenberg, J. C., GE, Y. ‐., & Hartnett, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31964-6 · Cited by 85 · see citing works

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

Eissenberg, J. C., James, T. C., Foster-Hartnett, D. M., Hartnett, T., Ngan, V, & Elgin, S. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9923 · Cited by 588 · see citing works

A heat shock-activated cDNA rescues the recessive lethality of mutations in the heterochromatin-associated protein HP1 of Drosophila melanogaster

Eissenberg, J. C., & Hartnett, T. (1993) · Molecular and General Genetics MGG · doi:10.1007/bf00280383 · Cited by 43 · see citing works

Heterochromatin protein 1, a known suppressor of position-effect variegation, is highly conserved inDrosophila

Clark, R. F., & Elgin, S. C. R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.22.6067 · Cited by 37 · see citing works

The genomic silencing of position-effect variegation in Drosophila melanogaster: interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1

Delattre, M., Spierer, A., Tonka, C.-H., & Spierer, P. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.23.4253 · Cited by 79 · see citing works

Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation

Schwendemann, A., Matkovic, T., Linke, C., Klebes, A., Hofmann, A., & Korge, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705595105 · Cited by 13 · see citing works