The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIAS
Abstract
▪ Abstract Many chromosome abnormalities, especially translocations or inversions, are closely associated with a particular morphologic or phenotypic subtype of leukemia, lymphoma, or sarcoma. Cloning the genes at the breakpoints of these rearrangements has had a major impact on our understanding of the molecular biology of cancer. One such gene is MLL (myeloid-lymphoid or mixed lineage leukemia) located at chromosome band 11q23. The target gene(s) of MLL is unknown at present, but because of its homology to the trithorax gene in Drosophila as well as experimental data from mice, it appears to be involved in maintaining the function of some of the homeobox genes. Most genes involved in translocations have homologs in other organisms. Comparison of the functions of these genes in human cells with their function in other systems has enriched our understanding of their role in cell biology.
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Cites
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Self-citationA cell cycle regulator potentially involved in genesis of many tumor types
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Transcription Factors, Normal Myeloid Development, and Leukemia
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High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia
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Cited by
Song, W.-J., Sullivan, M. G., Legare, R. D., Hutchings, S., Tan, X., Kufrin, D., Ratajczak, J., Resende, I. C., Haworth, C., Hock, R., et al. (1999) · Nature Genetics · doi:10.1038/13793 · Cited by 1,100
Shilatifard, A. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051710-134100 · Cited by 1,091
Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
Chromosome aberrations in solid tumors
Albertson, D. G., Collins, C., McCormick, F., & Gray, J. W. (2003) · Nature Genetics · doi:10.1038/ng1215 · Cited by 812
Origins of chromosome translocations in childhood leukaemia
Greaves, M. F., & Wiemels, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1164 · Cited by 699
Metadata
- Authors
- Rowley, J. D.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 1998-12
- Volume
- 32
- Issue
- 1
- Pages
- 495-519
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2101085659
- Cited by
- 397
- References
- 8
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIAS. https://app.cochat.ai/papers/10.1146/annurev.genet.32.1.495
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- Rowley, J. D. (1998). THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIAS. Annual Review of Genetics. https://doi.org/10.1146/annurev.genet.32.1.495
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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