The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Retrotransposons Provide an Evolutionarily Robust Non-Telomerase Mechanism to Maintain Telomeres
Abstract
▪ Abstract Telomere molecular biology is far more complex than originally thought. Understanding biological systems is aided by study of evolutionary variants, and Drosophila telomeres are remarkable variants. Drosophila lack telomerase and the arrays of simple repeats generated by telomerase in almost all other organisms; instead, Drosophila telomeres are long tandem arrays of two non-LTR retrotransposons, HeT-A and TART. These are the first transposable elements found to have a bona fide role in cell structure, revealing an unexpected link between telomeres and what is generally considered to be parasitic DNA. In addition to providing insight into the cellular functions performed by telomeres, analysis of HeT-A and TART is providing insight into the evolution of chromosomes, retrotransposons, and retroviruses. Recent studies show that retrotransposon telomeres constitute a robust system for maintaining chromosome ends. These telomeres are now known to predate the separation of extant Drosophila species, allowing ample time for elements and hosts to coevolve interesting mechanisms.
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Cites
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An alternative pathway for yeast telomere maintenance rescues est1− senescence
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Origins and evolutionary relationships of retroviruses
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Mammalian telomeres and telomerase
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Mobile Elements: Drivers of Genome Evolution
Kazazian, H. H. (2004) · Science · doi:10.1126/science.1089670 · Cited by 1,922
PIWI-Interacting RNA: Its Biogenesis and Functions
Iwasaki, Y. W., Siomi, M. C., & Siomi, H. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034258 · Cited by 769
Genome evolution and biodiversity in teleost fish
Volff, J.-N. (2005) · Heredity · doi:10.1038/sj.hdy.6800635 · Cited by 677
Bilder, D. (2004) · Genes & Development · doi:10.1101/gad.1211604 · Cited by 553
The Structure and Function of Telomerase Reverse Transcriptase
Autexier, C., & Lue, N. F. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142412 · Cited by 489
Metadata
- Authors
- Pardue, M.-L., & DeBaryshe, P. G.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2003-12
- Volume
- 37
- Issue
- 1
- Pages
- 485-511
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2110433308
- Cited by
- 224
- References
- 8
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pardue, M.-L., & DeBaryshe, P. G. (2003). Retrotransposons Provide an Evolutionarily Robust Non-Telomerase Mechanism to Maintain Telomeres. Annual Review of Genetics. https://doi.org/10.1146/annurev.genet.38.072902.093115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
