The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis
Open accessAbstract
After reporting her observations of ring chromosomes, McClintock followed broken chromatids through successive cycles of cell division, in which she could observe the behavior of the "monstrous" chromosome 9 through meiosis and crossing-over. McClintock reported in a long series of articles that the chromatid breakage-fusion-bridge (BFB) cycle occurred only in the germ cells and endosperm, while the chromosome BFB continued in the sporophyte, which meant that she could selectively produce persistent variegation in plant tissues.
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Misrepair can produce chromosome bridges.
“The latter can lead to the formation of chromosome bridges (McClintock, 1939; Umbreit et al., 2020), where a fused chromosome with two centromeres can either break during cytokinesis or persist and form a bridge between two newly forming nuclei after anaphase (Liu et al., 2014; Maciejowski et al., 2015).”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as McClintock, 1939
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McClintock, B. (1931) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.17.8.485 · Cited by 56 · see citing works
Self-citationCYTOGENETIC STUDIES OF AN INTERCHANGE BETWEEN CHROMOSOMES 8 AND 9 IN MAIZE
Burnham, C. R. (1934) · Genetics · doi:10.1093/genetics/19.5.430 · Cited by 32 · see citing works
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- Authors
- McClintock, B.
- Affiliations
- University of Missouri (US)
- Corresponding author
- McClintock, Barbara
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1939-08
- Volume
- 25
- Issue
- 8
- Pages
- 405-416
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1077932
- OpenAlex
- W1977172248
- Cited by
- 559
- References
- 2
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 12 · 2023: 20 · 2022: 19 · 2021: 22 · 2020: 17 · 2019: 16 · 2018: 19 · 2017: 19 · 2016: 23 · 2015: 21 · 2014: 11 · 2013: 22 · 2012: 15
- FWCI
- 27.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Profiles in Science (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Genetic and Mutation Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- ring chromosomes, chromosome 9, meiosis, crossing over, endosperm, sporophyte, germ cells, McClintock
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