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Cited by 647

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Mechanisms of Cyclic-di-GMP Signaling in Bacteria

Jenal, Urs, Malone, Jacob·2006·Annual Review of Genetics

Abstract

Cyclic-di-GMP is a ubiquitous second messenger in bacteria. The recent discovery that c-di-GMP antagonistically controls motility and virulence of single, planktonic cells on one hand and cell adhesion and persistence of multicellular communities on the other has spurred interest in this regulatory compound. Cellular levels of c-di-GMP are controlled through the opposing activities of diguanylate cyclases and phosphodiesterases, which represent two large families of output domains found in bacterial one- and two-component systems. This review concentrates on structural and functional aspects of diguanylate cyclases and phosphodiesterases, and on their role in transmitting environmental stimuli into a range of different cellular functions. In addition, we examine several well-established model systems for c-di-GMP signaling, including Pseudomonas, Vibrio, Caulobacter, and Salmonella.

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Crossref · 10.1146/annurev.genet.40.110405.090423

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Metadata

Authors
Jenal, U., & Malone, J.
Venue
Annual Review of Genetics
Published
2006-12-01
Volume
40
Issue
1
Pages
385-407
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
OpenAlex
W2168421163
Cited by
647
References
2
FWCI
2.32
Type
journal article
Language
en
Open access
closed

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