Nitric oxide regulation of bacterial biofilms

Arora, Dhruv P.; Hossain, Sajjad; Xu, Yueming; Boon, Elizabeth M.

doi:10.1021/bi501476n

Cited by 206Bacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyNitric Oxide and Endothelin Effects

Nitric oxide regulation of bacterial biofilms

Arora, Dhruv P., Hossain, Sajjad, Xu, Yueming, Boon, Elizabeth M.·2015·Biochemistry

DOI 10.1021/bi501476n

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Abstract

Biofilms are surface-associated, multicellular communities of bacteria. Once established, they are extremely difficult to eradicate by antimicrobial treatment. It has been demonstrated in many species that biofilm formation may be regulated by the diatomic signaling molecule nitric oxide (NO). Although this is still a relatively new area of research, we review here the literature reporting an effect of NO on bacterial biofilm formation, emphasizing dose-dependent responses to NO concentrations when possible. Where it has been investigated, the underlying NO sensors or signaling pathways are also discussed. Most of the examples of NO-mediated biofilm regulation have been documented with exogenously applied NO, but we also survey possible natural sources of NO in biofilm regulation, including endogenously generated NO. Finally, because of the apparent broad-spectrum, antibiofilm effects of NO, NO-releasing materials and prodrugs have also been explored in this minireview.

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Nitrite can exert pH-dependent antimicrobial effects via formation of reactive secondary nitrogen oxides that can disrupt aerobic respiration, inhibit bacterial acid production, and disrupt biofilm formation.
“Nitrite can exert pH-dependent antimicrobial effects[204,232,233] via formation of reactive secondary nitrogen oxides that can disrupt aerobic respiration[234], inhibit bacterial acid production, and disrupt biofilm formation[235–237].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [237]
High salivary nitrite concentrations may exert antimicrobial effects elsewhere in the oral cavity and gut, possibly disrupting community composition or function of biologically beneficial populations of nitrate-reducing bacteria.
“Yet, despite these localized, periodontal effects on microbial populations, high salivary nitrite concentrations may also exert antimicrobial effects elsewhere in the oral cavity and gut, possibly disrupting community composition or function of biologically beneficial populations of nitrate-reducing bacteria[204,232–237].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [237]

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Authors: Arora, D. P., Hossain, S., Xu, Y., & Boon, E. M.
Affiliations: Stony Brook University (US)
Corresponding author: Boon, Elizabeth M.
ORCID: Xu, Yueming
Boon, Elizabeth M.
Venue: Biochemistry
Publisher: American Chemical Society (ACS)
Published: 2015-06-02
Volume: 54
Issue: 24
Pages: 3717-3728
ISSN: 0006-2960 (ISSN-L)
1520-4995
DOI: 10.1021/bi501476n
OpenAlex: W2413004782
Cited by: 206
References: 136
Citations by year: 2026: 14 · 2025: 16 · 2024: 19 · 2023: 20 · 2022: 13 · 2021: 24 · 2020: 29 · 2019: 17 · 2018: 24 · 2017: 19 · 2016: 9 · 2015: 2
FWCI: 1.73
Type: journal article
Language: en
Open access: closed
Locations: Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: nitric oxide, bacterial biofilms, dose-response relationship, endogenous nitric oxide, antibiofilm agents, prodrugs
MeSH terms: Bacterial Proteins, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemeproteins, Models, Biological, Nitric Oxide, Second Messenger Systems, Biofilms

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Nitric oxide regulation of bacterial biofilms

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