The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
SILENCING OF THE MAMMALIAN X CHROMOSOME
Abstract
▪ Abstract Mammalian X chromosome inactivation is one of the most striking examples of epigenetic gene regulation. Early in development one of the pair of ∼160-Mb X chromosomes is chosen to be silenced, and this silencing is then stably inherited through subsequent somatic cell divisions. Recent advances have revealed many of the chromatin changes that underlie this stable silencing of an entire chromosome. The key initiator of these changes is a functional RNA, XIST, which is transcribed from, and associates with, the inactive X chromosome, although the mechanism of association with the inactive X and recruitment of facultative heterochromatin remain to be elucidated. This review describes the unique evolutionary history and resulting genomic structure of the X chromosome as well as the current understanding of the factors and events involved in silencing an X chromosome in mammals.
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Cites
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Jaillon, O., Aury, J.-M., Brunet, F., Petit, J.-L., Stange-Thomann, N., Mauceli, E., Bouneau, L., Fischer, C., Ozouf-Costaz, C., Bernot, A., et al. (2004) · Nature · doi:10.1038/nature03025 · Cited by 1,966
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The Xist RNA Gene Evolved in Eutherians by Pseudogenization of a Protein-Coding Gene
Duret, L., Chureau, C., Samain, S., Weissenbach, J., & Avner, P. (2006) · Science · doi:10.1126/science.1126316 · Cited by 418
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Metadata
- Authors
- Chow, J. C., Yen, Z., Ziesche, S. M., & Brown, C. J.
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2005-09-01
- Volume
- 6
- Issue
- 1
- Pages
- 69-92
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2118239133
- Cited by
- 216
- References
- 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chow, J. C., Yen, Z., Ziesche, S. M., & Brown, C. J. (2005). SILENCING OF THE MAMMALIAN X CHROMOSOME. Annual Review of Genomics and Human Genetics. https://doi.org/10.1146/annurev.genom.6.080604.162350
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