Cited by 135Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsSex and Gender in Healthcare

Sex Differences in the Expression of Drug-Metabolizing and Transporter Genes in Human Liver

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Yang, Lun, Li, Yan·2012·Journal of Drug Metabolism & Toxicology

Abstract

Human sex differences in the gene expression of drug metabolizing enzymes and transporters (DMETs) introduce differences in drug absorption, distribution, metabolism and excretion, possibly affecting drug efficacy and adverse reactions. However, existing studies aimed at identifying dimorphic expression differences of DMET genes are limited by sample size and the number of genes profiled. Focusing on a list of 374 DMET genes, we analyzed a previously published gene expression data set consisting of human male (n=234) and female (n=193) liver samples, and identified 77 genes showing differential expression due to sex. To delineate the biological functionalities and regulatory mechanisms for the differentially expressed DMET genes, we conducted a co-expression network analysis. Moreover, clinical implications of sex differences in the expression of human hepatic DMETs are discussed. This study may contribute to the realization of personalized medicine by better understanding the inter-individual differences between males and females in drug/xenobiotic responses and human disease susceptibilities.

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Authors
Yang, L., & Li, Y.
Affiliations
National Center for Toxicological Research (US)
ORCID
Li, Yan
Venue
Journal of Drug Metabolism & Toxicology
Published
2012
Volume
3
Issue
3
Pages
1000119-1000119
ISSN
2157-7609 (ISSN-L)
OpenAlex
W2185216198
Cited by
135
References
53
Citations by year
2026: 14 · 2025: 18 · 2024: 4 · 2023: 18 · 2022: 10 · 2021: 17 · 2020: 14 · 2019: 12 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 2 · 2013: 4
FWCI
3.63
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Drug Metabolism & Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion, cc-by)
  • PubMed Central (acceptedVersion, cc-by)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders
National Institutes of Health (FD999999)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Keywords
sex differences, drug-metabolizing enzymes, drug transporters, human liver, gene expression, differential gene expression, co-expression network, personalized medicine, interindividual variability, drug response

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