The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
Open accessAbstract
TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood. Here we found that TRPV1 was functionally expressed in CD4+ T cells, where it acted as a non–store-operated Ca2+ channel and contributed to T cell antigen receptor (TCR)-induced Ca2+ influx, TCR signaling and T cell activation. In models of T cell–mediated colitis, TRPV1 promoted colitogenic T cell responses and intestinal inflammation. Furthermore, genetic and pharmacological inhibition of TRPV1 in human CD4+ T cells recapitulated the phenotype of mouse Trpv1−/− CD4+ T cells. Our findings suggest that inhibition of TRPV1 could represent a new therapeutic strategy for restraining proinflammatory T cell responses.
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Cites
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Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
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TRPV3 is a temperature-sensitive vanilloid receptor-like protein
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Cited by
Kashem, S. W., Riedl, M. S., Yao, C., Honda, C. N., Vulchanova, L., & Kaplan, D. H. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.016 · Cited by 448
Chiang, E. Y., Li, T., Jeet, S., Peng, I., Zhang, J., Lee, W. P., DeVoss, J., Caplazi, P., Chen, J., Warming, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms14644 · Cited by 108
Glial functions in the blood-brain communication at the circumventricular organs
Miyata, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.991779 · Cited by 66
Metadata
- Authors
- Bertin, S., Aoki-Nonaka, Y., de Jong, P. R., Nohara, L. L., Xu, H., Stanwood, S. R., Srikanth, S., Lee, J., To, K., Abramson, L., Yu, T., Han, T., Touma, R., Li, X., González-Navajas, J. M., Herdman, S., Corr, M., Fu, G., Dong, H., Gwack, Y., Franco, A., Jefferies, W. A., & Raz, E.
- Venue
- Nature Immunology
- Published
- 2014-10-05
- Volume
- 15
- Issue
- 11
- Pages
- 1055-1063
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1981577795
- Cited by
- 260
- References
- 45
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Bertin, S., Aoki-Nonaka, Y., de Jong, P. R., Nohara, L. L., Xu, H., Stanwood, S. R., Srikanth, S., Lee, J., To, K., Abramson, L., Yu, T., Han, T., Touma, R., Li, X., González-Navajas, J. M., Herdman, S., Corr, M., Fu, G., Dong, H., . . . Raz, E. (2014). The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells. Nature Immunology. https://doi.org/10.1038/ni.3009
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