The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Genetic and Structural Evidence for Antigen Selection of Anti-DNA Antibodies
Abstract
The primary structure of anti-DNA antibodies is highly diverse, a result of different germline variable (V) gene use, different combinations of immunoglobulin gene segments, peculiar heavy chain complementarity determining region 3 (H-CDR3) segments, and somatic mutations. Nevertheless, tertiary structure predictions reveal common features that yield information about likely contact sites in the anti-DNA combining site. That these contacts are involved with DNA binding is supported by recurrent features of a newly compiled set of homology groups of 13 variable regions of heavy chains (VH) and 11 variable regions of light chains (VL), characteristic pattern of somatic mutations, and the results of site-directed mutagenesis. The role of antigen in the etiology of the autoimmune response is viewed in light of recent data on overlaps between anti-DNA and anti-nucleic acid binding protein specificities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ellenberger, T. E., Brandl, C. J., Struhl, K., & Harrison, S. C. (1992) · Cell · doi:10.1016/s0092-8674(05)80070-4 · Cited by 972
Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and Medicine
Tan, E. M. (1982) · Advances in Immunology · doi:10.1016/s0065-2776(08)60836-6 · Cited by 965
Receptor editing in self-reactive bone marrow B cells.
Tiegs, S. L., Russell, D. M., & Nemazee, D. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.4.1009 · Cited by 766
Arents, G., Burlingame, R. W., Wang, B. C., Love, W. E., & Moudrianakis, E. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10148 · Cited by 759
The role of clonal selection and somatic mutation in autoimmunity
Shlomchik, M. J., Marshak-Rothstein, A., Wolfowicz, C. B., Rothstein, T. L., & Weigert, M. G. (1987) · Nature · doi:10.1038/328805a0 · Cited by 701
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.
Shlomchik, M., Mascelli, M., Shan, H., Radic, M. Z., Pisetsky, D., Marshak-Rothstein, A., & Weigert, M. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.1.265 · Cited by 666
Self-citationNucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.
Mohan, C., Adams, S., Stanik, V, & Datta, S. K. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.5.1367 · Cited by 627
Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids.
Lafer, E. M., Rauch, J., Andrzejewski, C., Mudd, D., Furie, B., Furie, B., Schwartz, R. S., & Stollar, B. D. (1981) · The Journal of experimental medicine · doi:10.1084/jem.153.4.897 · Cited by 536
Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding
Steitz, T. A. (1990) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500005552 · Cited by 505
Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
Erikson, J., Radic, M. Z., Camper, S. A., Hardy, R. R., Carmack, C., & Weigert, M. (1991) · Nature · doi:10.1038/349331a0 · Cited by 474
Self-citation
Cited by
Predominant Autoantibody Production by Early Human B Cell Precursors
Wardemann, H., Yurasov, S., Schaefer, A., Young, J. W., Meffre, E., & Nussenzweig, M. C. (2003) · Science · doi:10.1126/science.1086907 · Cited by 2,083
Cellular and genetic mechanisms of self tolerance and autoimmunity
Goodnow, C. C., Sprent, J., de St Groth, B. F., & Vinuesa, C. G. (2005) · Nature · doi:10.1038/nature03724 · Cited by 699
Coutinho, A., Kazatchkine, M. D., & Avrameas, S. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80053-0 · Cited by 573
From T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik, M. J., Craft, J. E., & Mamula, M. J. (2001) · Nature Reviews Immunology · doi:10.1038/35100573 · Cited by 572
Antigen-induced B-cell death and elimination during germinal-centre immune responses
Shokat, K. M., & Goodnow, C. C. (1995) · Nature · doi:10.1038/375334a0 · Cited by 375
Metadata
- Authors
- Radic, M. Z.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1994-01-01
- Volume
- 12
- Issue
- 1
- Pages
- 487-520
- ISSN
- 0732-0582 (ISSN-L)
- OpenAlex
- W2134755638
- Cited by
- 454
- References
- 40
- FWCI
- 23.26
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Genetic and Structural Evidence for Antigen Selection of Anti-DNA Antibodies. https://app.cochat.ai/papers/10.1146/annurev.immunol.12.1.487
- The paper
- Radic, M. Z. (1994). Genetic and Structural Evidence for Antigen Selection of Anti-DNA Antibodies. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.12.1.487
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
