The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Paracrine Cytokine Adjuvants in Cancer Immunotherapy
Abstract
Advances in our understanding of the molecular events of antigen recognition by T cells and T cell activation are opening up new approaches to cancer immunotherapy. The identification and cloning of cytokines provide one important set of tools for manipulating immunologic responses. For cancer therapy, cytokines such as interleukin-2 have been administered systemically. However, systemic administration of cytokines ignores the paracrine nature of their action. Recently, an alternative approach has been explored that produces high concentrations of cytokines local to the tumor cells. This is achieved either by transduction of the tumor cells with the cytokine gene or by mixture of the tumor cells with cytokine containing biodegradable polymer microspheres. Under these circumstances, the locally released cytokine produces a strong local inflammatory response specific to the particular cytokine. In some cases, a potent tumor-specific T cell response results, capable of mediating regression of systemic tumor deposits. This paracrine delivery of cytokines can therefore be considered as a new type of adjuvant in the design of vaccines for cancer as well as microbial infections.
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Cites
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Cited by
Pizzoferrato, E., Chu, N. R., Hawley, T. S., Lieu, F. H. L., Barber, B. H., Hawley, R. G., Watts, T. H., & Berinstein, N. L. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.18-2217 · Cited by 28
Metadata
- Authors
- Pardoll, D. M.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1995-01-01
- Volume
- 13
- Issue
- 1
- Pages
- 399-415
- ISSN
- 0732-0582 (ISSN-L)
- OpenAlex
- W2169388007
- Cited by
- 369
- References
- 21
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pardoll, D. M. (1995). Paracrine Cytokine Adjuvants in Cancer Immunotherapy. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.13.1.399
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
