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IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39
Abstract
▪ Abstract Over the past three years, CD40 and its ligand (gp39, CD40L, TBAM) have been shown to be essential for humoral immune responses to thymus-dependent antigens. However, as the tissue distribution widens for those cells that express CD40 and gp39, we can now show that this ligand-receptor pair also plays an important role in the selection of self-reactive T cells in the thymus (central tolerance) and the regulation of tolerance in mature T cells (peripheral tolerance). Advances in our understanding of the molecular basis for CD40 biology is based in two areas of research. First, a major breakthrough in our understanding of how CD40 transduces biological events centers on the identification of a novel protein that binds to the cytoplasmic tail of CD40 and may act as a signal transducing molecule. Secondly, advances in molecular modeling and mutagenesis of this ligand-receptor pair have helped to identify the critical receptor/ligand contacts in the gp39/CD40 complex. Advances in each of these areas are discussed.
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Citations
Cited by
CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,539
Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off
Parijs, L. V., & Abbas, A. K. (1998) · Science · doi:10.1126/science.280.5361.243 · Cited by 965
Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834
Cellular and genetic mechanisms of self tolerance and autoimmunity
Goodnow, C. C., Sprent, J., de St Groth, B. F., & Vinuesa, C. G. (2005) · Nature · doi:10.1038/nature03724 · Cited by 699
Kmiecik, J., Poli, A., Brons, N. H. C., Waha, A., Eide, G. E., Enger, P. Ø., Zimmer, J., & Chekenya, M. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.08.013 · Cited by 389
Metadata
- Authors
- Foy, T. M., Aruffo, A., Bajorath, J., Buhlmann, J. E., & Noelle, R. J.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1996-04
- Volume
- 14
- Issue
- 1
- Pages
- 591-617
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2084072841
- Cited by
- 626
- References
- 0
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Foy, T. M., Aruffo, A., Bajorath, J., Buhlmann, J. E., & Noelle, R. J. (1996). IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.14.1.591
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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