Immunosenescence of ageing

Prevention and Control of Influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP)

Fiore, A. E., Shay, D. K., Broder, K., Iskander, J. K., Uyeki, T. M., Mootrey, G., Bresee, J. S., & Cox, N. S. (2001) · PsycEXTRA Dataset · doi:10.1037/e548312006-001 · Cited by 5,006 · see citing works

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576 · see citing works

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606 · see citing works

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

Lord, G. M., Matarese, G., Howard, J. K., Baker, R. J., Bloom, S. R., & Lechler, R. I. (1998) · Nature · doi:10.1038/29795 · Cited by 2,160 · see citing works

Changes in thymic function with age and during the treatment of HIV infection

Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893 · see citing works

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512 · see citing works

The aging immune system: primer and prospectus

Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165 · cited 2× · see citing works

Natural regulatory T cells in infectious disease

Belkaid, Y., & Rouse, B. T. (2005) · Nature Immunology · doi:10.1038/ni1181 · Cited by 1,036 · see citing works

The Endocrinology of Aging

Lamberts, S. W. J., van den Beld, A. W., & van der Lely, A.-J. (1997) · Science · doi:10.1126/science.278.5337.419 · Cited by 980 · see citing works

Vaccines for preventing influenza in the elderly

Demicheli, V., Jefferson, T., Pietrantonj, C. D., Ferroni, E., Thorning, S., Thomas, R. E., & Rivetti, A. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004876.pub4 · Cited by 706 · see citing works

Epidemiology and risk factors for pancreatic cancer

Lowenfels, A. B., & Maisonneuve, P. (2006) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.10.001 · Cited by 635 · see citing works

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

Foy, T. M., Aruffo, A. A., Bajorath, J., Buhlmann, J. E., & Noelle, R. J. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.591 · Cited by 625 · see citing works

Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review

Jefferson, T., Rivetti, D., Rivetti, A., Rudin, M., Di Pietrantonj, C., & Demicheli, V (2005) · The Lancet · doi:10.1016/s0140-6736(05)67339-4 · Cited by 601 · see citing works

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

Howard, J. K., Lord, G. M., Matarese, G., Vendetti, S., Ghatei, M. A., Ritter, M. A., Lechler, R. I., & Bloom, S. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6762 · Cited by 566 · see citing works

Cancer burden in the aged: an epidemiologic and demographic overview.

Yancik, R. (1997) · PubMed · Cited by 558 · see citing works

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

Scollay, R. G., Butcher, E. C., & Weissman, I. L. (1980) · European Journal of Immunology · doi:10.1002/eji.1830100310 · Cited by 555 · see citing works

Thymopoiesis independent of common lymphoid progenitors.

Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A. (2003) · Nature Immunology · doi:10.1038/ni878 · Cited by 544 · see citing works

CD4+CD25+ regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid

Amelsfort, J. M. R. M.-V., van der Wurff‐Jacobs, K. M. G., Bijlsma, J. W. J., Lafeber, F. P. J. G., & Taams, L. S. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20499 · Cited by 531 · see citing works

The Role of the Thymus in Immune Reconstitution in Aging, Bone Marrow Transplantation, and HIV-1 Infection

Haynes, B. F., Markert, M. L., Sempowski, G. D., Patel, D. D., & Hale, L. P. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.529 · Cited by 502 · see citing works

The Involution of the Ageing Human Thymic Epithelium is Independent of Puberty

Steinmann, G. G., KLAUS, B. M., & Müller-Hermelink, H. K. (1985) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1985.tb01916.x · Cited by 455 · see citing works

Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells

Liang, Y., Zant, G. E. V., & Szilvassy, S. J. (2005) · Blood · doi:10.1182/blood-2004-11-4282 · Cited by 384 · see citing works

The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age

Gregg, R., Smith, C. M., Clark, F. J., Dunnion, D., Khan, N., Chakraverty, R. K., Nayak, L., & Moss, P. A. H. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02798.x · Cited by 377 · see citing works

Generation of Functional Thymocytes in the Human Adult

Jamieson, B. D., Douek, D. C., Killian, S., Hultin, L. E., Scripture-Adams, D. D., Giorgi, J. V., Marelli, D., Koup, R. A., & Zack, J. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80056-4 · Cited by 367 · see citing works

Thymic involution with ageing: obsolescence or good housekeeping?

George, A. J. T., & Ritter, M. A. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80543-3 · Cited by 364 · see citing works

Aging and Immune Function

Miller, R. A. (1991) · International review of cytology · doi:10.1016/s0074-7696(08)61527-2 · Cited by 353 · see citing works

Changes in the Human Thymus During Aging

Steinmann, G. G. (1986) · Current topics in pathology · doi:10.1007/978-3-642-82480-7_2 · Cited by 346 · see citing works

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

von Freeden-Jeffry, U., Solvason, N. W., Howard, M., & Murray, R. (1997) · Immunity · doi:10.1016/s1074-7613(00)80517-8 · Cited by 332 · see citing works

Thymic output in aged mice

Hale, J. S., Boursalian, T. E., Turk, G. L., & Fink, P. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601040103 · Cited by 322 · see citing works

IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation

Mackall, C. L., Fry, T. J., Bare, C., Morgan, P. B., Galbraith, A., & Gress, R. E. (2001) · Blood · doi:10.1182/blood.v97.5.1491 · Cited by 300 · see citing works

Leukemia Inhibitory Factor, Oncostatin M, IL-6, and Stem Cell Factor mRNA Expression in Human Thymus Increases with Age and Is Associated with Thymic Atrophy

Sempowski, G. D., Hale, L. P., Sundy, J. S., Massey, J. M., Koup, R. A., Douek, D. C., Patel, D. D., & Haynes, B. F. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.2180 · Cited by 298 · see citing works

Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses

Eaton, S. M., Burns, E. M., Kusser, K. L., Randall, T. D., & Haynes, L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041395 · Cited by 279 · see citing works

Apoptosis in sepsis: a new target for therapeutic exploration

Oberholzer, C., Oberholzer, A., Clare-Salzler, M. J., & Moldawer, L. L. (2001) · The FASEB Journal · doi:10.1096/fj.00-058rev · Cited by 271 · see citing works

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2433717100 · Cited by 270 · see citing works

Role of regulatory T cells in human diseases

Chatila, T. A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.08.047 · Cited by 264 · see citing works

Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes

Lazuardi, L., Jenewein, B., Wolf, A. M., Pfister, G., Tzankov, A., & Grubeck‐Loebenstein, B. (2005) · Immunology · doi:10.1111/j.1365-2567.2004.02006.x · Cited by 263 · see citing works

Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation

Min, D., Taylor, P. A., Panoskaltsis‐Mortari, A., Chung, B., Danilenko, D. M., Farrell, C. L., Lacey, D. L., Blazar, B. R., & Weinberg, K. I. (2002) · Blood · doi:10.1182/blood.v99.12.4592 · Cited by 261 · see citing works

A Clinical Trial of Retroviral-Mediated Transfer of arev-Responsive Element Decoy Gene Into CD34+Cells From the Bone Marrow of Human Immunodeficiency Virus-1–Infected Children

Kohn, D. B., Bauer, G., Rice, C., Rothschild, J. C., Carbonaro, D. A., Valdez, P., Hao, Q., Zhou, C., Bahner, I., Kearns, K., et al. (1999) · Blood · doi:10.1182/blood.v94.1.368.413a47_368_371 · Cited by 260 · see citing works

Regulatory T cells in virus infections

Rouse, B. T., Sarangi, P. P., & Suvas, S. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00412.x · Cited by 255 · see citing works

The Decline in B Lymphopoiesis in Aged Mice Reflects Loss of Very Early B-Lineage Precursors

Miller, J. P., & Allman, D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2326 · Cited by 255 · see citing works

Analysis of the human thymic perivascular space during aging

Flores, K. G., Li, J., Sempowski, G. D., Haynes, B. F., & Hale, L. P. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7558 · Cited by 247 · see citing works

Molecular Cloning and Biological Characterization of a Novel Murine Lymphoid Growth Factor

Sims, J. E., Williams, D. E., Morrissey, P., Garka, K. E., Foxworthe, D., Price, V. L., Friend, S. L., Farr, A. G., Bedell, M. A., Jenkins, N. A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.671 · Cited by 236 · see citing works

Age-Related Impaired Type 1 T Cell Responses to Influenza: Reduced Activation Ex Vivo, Decreased Expansion in CTL Culture In Vitro, and Blunted Response to Influenza Vaccination In Vivo in the Elderly

Deng, Y., Jing, Y., Campbell, A. E., & Gravenstein, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3437 · Cited by 230 · see citing works

Immunosenescence and germinal center reaction

Zheng, B. Q., Han, S., Takahashi, Y., & Kelsoe, G. H. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01028.x · Cited by 229 · see citing works

Mismatch between the 1997/1998 influenza vaccine and the major epidemic A(H3N2) virus strain as the cause of an inadequate vaccine-induced antibody response to this strain in the elderly

de Jong, J. C., BEYER, W. E. P., Palache, A. M., Rimmelzwaan, G. F., & Osterhaus, A. D. M. E. (2000) · Journal of Medical Virology · doi:10.1002/(sici)1096-9071(200005)61:1 · Cited by 229 · see citing works

Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7

Bolotin, E., Smogorzewska, M., Smith, S. M., Widmer, M. B., & Weinberg, K. I. (1996) · Blood · doi:10.1182/blood.v88.5.1887.1887 · Cited by 225 · see citing works

Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood

Wing, K., Ekmark, A., Karlsson, H., Rudin, A., & Suri‐Payer, E. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01412.x · Cited by 225 · see citing works

The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts

Rebel, V. I., Miller, C., Eaves, C. J., & Lansdorp, P. (1996) · Blood · doi:10.1182/blood.v87.8.3500.bloodjournal8783500 · Cited by 223 · see citing works

CD4+CD25+Foxp3+ T Cells and CD4+CD25−Foxp3+ T Cells in Aged Mice

Nishioka, T., Shimizu, J., Iida, R., Yamazaki, S., & Sakaguchi, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6586 · Cited by 220 · see citing works

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

Muegge, K., Vila, M. P., & Durum, S. K. (1993) · Science · doi:10.1126/science.7686307 · Cited by 214 · see citing works

Prevention and control of influenza, Recommendations of the Advisory Committee on Immunization Practices (ACIP)

Bridges, C. B., Harper, S. A., Fukuda, K., Uyeki, T. M., Cox, N. J., & Singleton, J. A. (2002) · Jagiellonian University Repository (Jagiellonian University) · Cited by 213 · see citing works

Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development

Haynes, B. F., Denning, S. M., Singer, K. H., & Kurtzberg, J. (1989) · Immunology Today · doi:10.1016/0167-5699(89)90232-6 · Cited by 208 · see citing works

Dynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging

de Haan, G., & Van Zant, G. (1999) · Blood · doi:10.1182/blood.v93.10.3294.410k07_3294_3301 · Cited by 208 · see citing works

Risk factors for prostate cancer.

Gann, P. H. (2002) · Europe PMC (PubMed Central) · Cited by 207 · see citing works

The role of the transcription factor Foxp3 in the development of regulatory T cells

Kim, J., & Rudensky, A. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00426.x · Cited by 207 · see citing works

T cell receptor excision circle assessment of thymopoiesis in aging mice

Sempowski, G. D., Gooding, M. E., Liao, H. X., Le, P. T., & Haynes, B. F. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(01)00122-5 · Cited by 206 · see citing works

Vaccines for preventing influenza in the elderly

Rivetti, D., Jefferson, T., Thomas, R. E., Rudin, M., Rivetti, A., Pietrantonj, C. D., & Demicheli, V. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004876.pub2 · Cited by 206 · see citing works

The Effect of Age on the B-Cell Repertoire

Weksler, M. E., & Szabo, P. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1006659401385 · Cited by 205 · see citing works

Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: systematic review

Jefferson, T., Smith, S., Demicheli, V., Harnden, A., Rivetti, A., & Pietrantonj, C. D. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17984-7 · Cited by 200 · see citing works

Functional assay for human CD4+CD25+ Treg cells reveals an age‐dependent loss of suppressive activity

Tsaknaridis, L., Spencer, L., Culbertson, N. E., Hicks, K., LaTocha, D. H., Chou, Y. K., Whitham, R. H., Bakke, A. C., Jones, R. E., Offner, H., et al. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10766 · Cited by 197 · see citing works

Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age

Stephan, R. P., Reilly, C. R., & Witte, P. L. (1998) · Blood · doi:10.1182/blood.v91.1.75 · Cited by 197 · see citing works

Update: Influenza Activity--United States, 1997-98 Season

(1998) · JAMA · doi:10.1001/jama.279.7.498-a · Cited by 183 · see citing works

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice.

Yang, X., Štědra, J., & Cerny, J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.959 · Cited by 182 · see citing works

The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways

Kim, K., Lee, C., Sayers, T. J., Muegge, K., & Durum, S. K. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.5735 · Cited by 181 · see citing works

Age-associated thymic atrophy is linked to a decline in IL-7 production

Andrew, D. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00213-3 · Cited by 170 · see citing works

T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool

Kong, F.-K., Chen, C.-L. H., Six, A., Hockett, R. D., & Cooper, M. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1536 · Cited by 169 · see citing works

Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development

Aspinall, R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3037 · Cited by 163 · see citing works

Regulation of thymic epithelium by keratinocyte growth factor

Erickson, M., Morkowski, S., Lehar, S. M., Gillard, G. O., Beers, C., Dooley, J., Rubin, J. S., Rudensky, A. Y., & Farr, A. G. (2002) · Blood · doi:10.1182/blood-2002-04-1036 · Cited by 154 · see citing works

CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans—impact of immunosenescence

Trzonkowski, P., Szmit, E., Myśliwska, J. M., & Myśliwski, A. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.02.002 · Cited by 152 · see citing works

Relative to adult marrow, fetal liver repopulates nearly five times more effectively long-term than short-term.

Harrison, D. E., Zhong, R. K., Jordan, C. T., Lemischka, I. R., & Astle, C. M. (1997) · PubMed · Cited by 147 · see citing works

CD4 CD25high regulatory T cells are not impaired in patients with primary Sjögren's syndrome

Gottenberg, J., Lavie, F., Abbed, K., Gasnault, J., Nevot, E. L., Delfraissy, J., Taoufik, Y., & Xavier Mariette, A. (2005) · Journal of Autoimmunity · doi:10.1016/j.jaut.2005.01.015 · Cited by 147 · see citing works

Early activation defects in T lymphocytes from aged mice

Miller, R. A., Gorcia, G., Kirk, C. J., & Witkowski, J. M. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01029.x · Cited by 146 · see citing works

Human lymph node morphology as a function of age and site.

Luscieti, P., Hubschmid, T., Cottier, H., Hess, M. W., & Sobin, L. H. (1980) · Journal of Clinical Pathology · doi:10.1136/jcp.33.5.454 · Cited by 145 · see citing works

Interleukin-7 is a critical growth factor in early human T-cell development

Plum, J. R., Smedt, M. D., Leclercq, G., Verhasselt, B., & Vandekerckhove, B. (1996) · Blood · doi:10.1182/blood.v88.11.4239.bloodjournal88114239 · Cited by 144 · see citing works

Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection

Po, J. L., Gardner, E. M., Anaraki, F., Katsikis, P. D., & Murasko, D. M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00010-6 · Cited by 143 · see citing works

Bone marrow and bone: a functional unit

Compston, J. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1730387 · Cited by 143 · see citing works

Risk Factors for Prostate Cancer

Shepherd, D. L. (2003) · Humana Press eBooks · doi:10.1385/1-59259-099-3:131 · Cited by 138 · see citing works

Human thymic epithelial cells produce interleukin 1.

Le, P. T., Tuck, D. T., Dinarello, C. A., Haynes, B. F., & Singer, K. H. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.8.2520 · Cited by 135 · see citing works

Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors

Stephan, R. P., Lill-Elghanian, D. A., & Witte, P. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1598 · Cited by 133 · see citing works

Aging and developmental transitions in the B cell lineage

Johnson, K. M. (2002) · International Immunology · doi:10.1093/intimm/dxf092 · Cited by 128 · see citing works

Effects of Aging on the Common Lymphoid Progenitor to Pro-B Cell Transition

Min, H., Montecino-Rodriguez, E., & Dorshkind, K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1007 · Cited by 126 · see citing works

Stage-specific alterations in murine B lymphopoiesis with age

Stephan, R. P., Sanders, V. M., & Witte, P. L. (1996) · International Immunology · doi:10.1093/intimm/8.4.509 · Cited by 126 · see citing works

Development and function of naturally occurring CD4+CD25+ regulatory T cells

Toda, A., & Piccirillo, C. A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0206095 · Cited by 125 · see citing works

Long-term erythropoietic repopulating ability of old, young, and fetal stem cells.

Harrison, D. E. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.157.5.1496 · Cited by 123 · see citing works

Are regulatory T-cells linked with aging?

Dejaco, C., Duftner, C., & Schirmer, M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.008 · Cited by 118 · see citing works

Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor.

Le, P. T., Lazorick, S., Whichard, L. P., Yang, Y., Clark, S., Haynes, B. F., & Singer, K. H. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.10.3310 · Cited by 114 · see citing works

Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis

Oberholzer, C., Oberholzer, A., Bahjat, F. R., Minter, R. M., Tannahill, C. L., Abouhamze, A. S., LaFace, D., Hutchins, B., Clare-Salzler, M. J., & Moldawer, L. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181338198 · Cited by 114 · see citing works

Age-Related Decrease in Mouse T Cell Progenitors

Tyan, M. L. (1977) · The Journal of Immunology · doi:10.4049/jimmunol.118.3.846 · Cited by 113 · see citing works

Age‐related changes in antibody repertoire: contribution from T cells

Song, H., Price, P. W., & Černý, J. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01027.x · Cited by 109 · see citing works

Development and aging of primitive hematopoietic stem cells in BALB/cBy mice

Chen, J., Astle, C. M., & Harrison, D. E. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(99)00018-1 · Cited by 109 · see citing works

The immune response of aged mice to influenza: Diminished T-cell proliferation, interleukin 2 production and cytotoxicity

Effros, R. B., & Walford, R. L. (1983) · Cellular Immunology · doi:10.1016/0008-8749(83)90237-x · Cited by 108 · see citing works

OX40 Costimulation Synergizes with GM-CSF Whole-Cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen

Murata, S., Ladle, B. H., Kim, P. S., Lutz, E. R., Wolpoe, M. E., Ivie, S. E., Smith, H. M., Armstrong, T. D., Emens, L. A., Jaffee, E. M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.974 · Cited by 106 · see citing works

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041933 · Cited by 102 · see citing works

Leptin Selectively Augments Thymopoiesis in Leptin Deficiency and Lipopolysaccharide-Induced Thymic Atrophy

Hick, R. W., Gruver, A. L., Ventevogel, M. S., Haynes, B. F., & Sempowski, G. D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.169 · Cited by 102 · see citing works

Effect of Thymectomy on Human Peripheral Blood T Cell Pools in Myasthenia Gravis

Sempowski, G. D., Thomasch, J. R., Gooding, M. E., Hale, L. P., Edwards, L. J., Ciafaloni, E., Sanders, D. B., Massey, J. M., Douek, D. C., Koup, R. A., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2808 · Cited by 102 · see citing works

Structure and Function of Human Growth Hormone: Implications for the Hematopoietins

Wells, J. A., & de Vos, A. M. (1993) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.bb.22.060193.001553 · Cited by 102 · see citing works

Apoptosis in sepsis: a new target for therapeutic exploration

Oberholzer, C., Oberholzer, A., Clare-Salzler, M. J., et al. (2001) · The FASEB Journal · doi:10.1096/fsb2fj00058rev · Cited by 98 · see citing works

T-cell activation through the antigen receptor. Part 2: Role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy

Nel, A. E., & Slaughter, N. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.124965 · Cited by 96 · see citing works

Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors.

Le, P. T., Kurtzberg, J., Brandt, S. J., Niedel, J. E., Haynes, B. F., & Singer, K. H. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.4.1211 · Cited by 94 · see citing works

Age-Associated Loss of Bone Marrow Hematopoietic Cells Is Reversed by GH and Accompanies Thymic Reconstitution

French, R. A., Broussard, S. R., Meier, W. A., Minshall, C. T., Arkins, S., Zachary, J. F., Dantzer, R., & Kelley, K. W. (2002) · Endocrinology · doi:10.1210/endo.143.2.8612 · Cited by 93 · see citing works

Decline in bone marrow proliferative capacity as a function of age

Mauch, P., Botnick, L., Hannon, E. C., Obbagy, J., & Hellman, S. (1982) · Blood · doi:10.1182/blood.v60.1.245.245 · Cited by 92 · see citing works

The human thymus

Haynes, B. F., & Hale, L. P. (1998) · Immunologic Research · doi:10.1007/bf02788750 · Cited by 92 · see citing works

Influenza A Virus‐Specific Cytotoxic T Lymphocyte Activity Declines with Advancing Age

Powers, D. C. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb05938.x · Cited by 81 · see citing works

CD4+CD25+‐Regulatory T Cells from Mouse to Man

Wing, K., Suri‐Payer, E., & Rudin, A. (2005) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2005.01634.x · Cited by 80 · see citing works

Growth hormone accelerates immune recovery following allogeneic T-cell–depleted bone marrow transplantation in mice

Chen, B. J., Cui, X., Sempowski, G. D., & Chao, N. J. A. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00196-6 · Cited by 69 · see citing works

The human thymus

Haynes, B. F., & Hale, L. P. (1998) · Immunologic Research · doi:10.1007/bf02788778 · Cited by 68 · see citing works

Effects of growth hormone on thymocyte development from progenitor cells in the bone marrow

Knyszynski, A., Adler-Kunin, S., & Globerson, A. (1992) · Brain Behavior and Immunity · doi:10.1016/0889-1591(92)90032-j · Cited by 63 · see citing works

Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment.

Sherwood, E. M., Blomberg, B. B., Xu, W., Warner, C. A., & Riley, R. L. (1998) · PubMed · Cited by 62 · see citing works

Aged Mice Develop Protective Antitumor Immune Responses with Appropriate Costimulation

Lustgarten, J., Dominguez, A. L., & Thoman, M. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4510 · Cited by 61 · see citing works

Cutting Edge: Senescent BALB/c Mice Exhibit Decreased Expression of λ5 Surrogate Light Chains and Reduced Development Within the Pre-B Cell Compartment

Sherwood, E. M., Blomberg, B. B., Xu, W., Warner, C. A., & Riley, R. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4472 · Cited by 59 · see citing works

Aging affect the anti-tumor potential of dendritic cell vaccination, but it can be overcome by co-stimulation with anti-OX40 or anti-4-1BB☆

Sharma, S., LUCIADOMINGUEZ, A., & Lustgarten, J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.002 · Cited by 58 · see citing works

On a causal mechanism of chronic thymic involution in man

Hartwig, M. G., & Steinmann, G. G. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90083-3 · Cited by 55 · see citing works

Growth Hormone–Induced Stimulation of Multilineage Human Hematopoiesis

Hanley, M. B., Napolitano, L. A., & McCune, J. M. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0322 · Cited by 55 · see citing works

Senescent B Lymphopoiesis is Balanced in Suppressive Homeostasis: Decrease in Interleukin-7 and Transforming Growth Factor-β Levels in Stromal Cells of Senescence-Accelerated Mice

Tsuboi, I., Morimoto, K., Hirabayashi, Y., Li, G., Aizawa, S., Mori, K. J., Kanno, J., & Inoue, T. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900607 · Cited by 55 · see citing works

Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells☆

Whisler, R. L., & Grants, I. S. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90033-n · Cited by 54 · see citing works

Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice

Henckaerts, E., Langer, J., & Snoeck, H. (2004) · Blood · doi:10.1182/blood-2003-12-4304 · Cited by 52 · see citing works

Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells

Miller, J. P., & Allman, D. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.003 · Cited by 50 · see citing works

Human thymic epithelium and T cell development: current issues and future directions.

Haynes, B. F. (1991) · PubMed · Cited by 47 · see citing works

Genetic regulation of hematopoietic stem cell exhaustion during development and growth

Yuan, R., Astle, C. M., Chen, J., & Harrison, D. E. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2004.10.014 · Cited by 42 · see citing works

Human B cel proliferative responses during aging. Reduced RNA synthesis and DNA replication after signal transduction by surface immunoglobulins compared to B cell antigenic determinants CD20 and CD40

Whisler, R. L., Williams, J. W., & Newhouse, Y. G. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90018-u · Cited by 42 · see citing works

Effect of age on marrow macrophage number and function

Wang, C. Q., Udupa, K. B., Xiao, H., & Lipschitz, D. A. (1995) · Aging Clinical and Experimental Research · doi:10.1007/bf03324349 · Cited by 42 · see citing works

The biology of aging

Ershler, W. B., & Longo, D. L. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19971001)80:7 · Cited by 41 · see citing works

Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy

Sempowski, G. D., Rhein, M. E., Scearce, R. M., & Haynes, B. F. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200211)32:11 · Cited by 38 · see citing works

Age-dependent changes in the cellularity and ultrastructure of the spleen of Fischer F344 rats

Cheung, H. T., & Nadakavukaren, M. J. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90004-0 · Cited by 35 · see citing works

Hyperleptinemia and reduced TNF-α secretion cause resistance of db/db mice to endotoxin

Madiehe, A. M., Mitchell, T. D., & Harris, R. B. S. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00610.2002 · Cited by 34 · see citing works

The role of the thymic microenvironment in promotion of early stages of human T cell maturation.

Bf, H. (1986) · PubMed · Cited by 31 · see citing works

Mass Vaccination for Annual and Pandemic Influenza

Schwartz, B., & WORTLEY, P. M. (2006) · Springer eBooks · doi:10.1007/3-540-36583-4_8 · Cited by 29 · see citing works

Review: Molecular evolution and the feasibility of an avian influenza virus becoming a pandemic strain––a conceptual shift

Shoham, D. (2006) · Virus Genes · doi:10.1007/s11262-005-0047-3 · Cited by 28 · see citing works

Age as predictor in patients with cutaneous melanoma submitted to sentinel lymph node biopsy

Caracò, C., Marone, U., Botti, G., Celentano, E., Lastoria, S., & Mozzillo, N. (2006) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2006.07.007 · Cited by 25 · see citing works

Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: A flow cytometric analysis

Connoy, A., Trader, M., & High, K. P. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.11.003 · Cited by 24 · see citing works

Untransfected and SV40-transfected fetal and postnatal human thymic stromal cells. Analysis of phenotype, cytokine gene expression and cytokine production.

Galy, A. H. M., Malefyt, R. D. W., Bárcena, A., Peterson, S. M., & Spits, H. (1993) · PubMed · Cited by 24 · see citing works

Failure of Rearranged TCR Transgenes to Prevent Age-Associated Thymic Involution

Lacorazza, H. D., Guevara-Patino, J. A., Weksler, M. E., Radu, D. L., & Nikolić‐Žugić, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.8.4262 · Cited by 23 · see citing works

Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis

Pahlavani, M. A., Richardson, A. G., & Cheung, H. T. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90005-4 · Cited by 21 · see citing works

Regulation of T Cell Development in the Thymus

Kaye, J. (2000) · Immunologic Research · doi:10.1385/ir:21:2-3:71 · Cited by 19 · see citing works

Breast cancer in the very elderly: treatment patterns and complications in a tertiary cancer center

Rosenkranz, K. M., Bedrosian, I., Feng, L., Hunt, K. K., Hartman, K., Lucci, A., Meric‐Bernstam, F., Kuerer, H. M., Singletary, E. S., Hwang, R. F., et al. (2006) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2006.06.019 · Cited by 19 · see citing works

The distribution, immune complex trapping ability and morphology of follicular dendritic cells in popliteal lymph nodes of aged rats.

Sato, H., & Dobashi, M. (1998) · PubMed · doi:10.14670/hh-13.99 · Cited by 14 · see citing works

Prolonged E55+ Retrovirus Expression in Aged Mice Is Associated with a Decline in the Anti-Virus Immune Response

Elrefaei, M., Blank, K. J., & Murasko, D. M. (2001) · Virology · doi:10.1006/viro.2001.1128 · Cited by 10 · see citing works

Universal Influenza Vaccination Recommendations

Swain, G. R., & Ransom, J. (2006) · Journal of Public Health Management and Practice · doi:10.1097/00124784-200607000-00003 · Cited by 5 · see citing works

[Age factors in architectonics of the splenic arterial vessels].

Vv, S., Kaplunova, O. A., & Te, O. (2003) · PubMed · Cited by 3 · see citing works

Update: influenza activity--United States, 2004-05 season.

(2005) · PubMed · Cited by 1 · see citing works

Proinflammatory Cytokines, Aging, and Age-Related Diseases

Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094 · see citing works

The vascular depression hypothesis: mechanisms linking vascular disease with depression

Taylor, W. D., Aizenstein, H. J., & Alexopoulos, G. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.20 · Cited by 923 · see citing works

Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients

Ali, H. R., Provenzano, E., Dawson, S., Blows, F. M., Liu, B., Shah, M., Earl, H. M., Poole, C. J., Hiller, L., Dunn, J., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu191 · Cited by 773 · see citing works

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

Horvath, S., Gurven, M., Levine, M. E., Trumble, B. C., Kaplan, H. S., Allayee, H., Ritz, B. R., Chen, B. H., Lu, A. T.-H., Rickabaugh, T. M., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1030-0 · Cited by 729 · see citing works

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chen, C., Liu, Y., Liu, Y., & Zheng, P. (2009) · Science Signaling · doi:10.1126/scisignal.2000559 · Cited by 680 · see citing works

Vaccine Adjuvants: from 1920 to 2015 and Beyond

Pasquale, A. D., Preiss, S., Silva, F. T. D., & Garçon, N. (2015) · Vaccines · doi:10.3390/vaccines3020320 · Cited by 653 · see citing works

Mechanisms and treatment of late-life depression

Alexopoulos, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0514-6 · Cited by 592 · see citing works

Frailty and sarcopenia: The potential role of an aged immune system

Wilson, D., Jackson, T., Sapey, E., & Lord, J. M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.006 · Cited by 573 · see citing works

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s Disease: Systematic Review and Meta-Analysis

Ng, A., Tam, W. W., Zhang, M. W., Ho, C. S., Husain, S. F., McIntyre, R. S., & Ho, R. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30487-6 · Cited by 572 · see citing works

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

Kollmann, T. R., Levy, O., Montgomery, R. R., & Goriely, S. (2012) · Immunity · doi:10.1016/j.immuni.2012.10.014 · Cited by 572 · see citing works

Thymic involution and immune reconstitution.

Lynch, H. E., Goldberg, G. L., Chidgey, A., Van den Brink, M. R. M., Boyd, R., & Sempowski, G. D. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.003 · Cited by 522 · see citing works

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

Alpert, A., Pickman, Y., Leipold, M., Rosenberg-Hasson, Y., Ji, X., Gaujoux, R., Rabani, H., Starosvetsky, E., Kveler, K., Schaffert, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0381-y · Cited by 513 · see citing works

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

Bolles, M., Deming, D., Long, K., Agnihothram, S., Whitmore, A., Ferris, M., Funkhouser, W., Gralinski, L., Totura, A., Heise, M., et al. (2011) · Journal of Virology · doi:10.1128/jvi.06048-11 · Cited by 477 · see citing works

Age-Associated B Cells

Cancro, M. P. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-092419-031130 · Cited by 464 · see citing works

Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.

Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463 · see citing works

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Thomas, R., Wang, W., & Su, D.-M. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-0173-8 · Cited by 442 · see citing works

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439 · see citing works

Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients

Horvath, S., & Ritz, B. R. (2015) · Aging · doi:10.18632/aging.100859 · Cited by 435 · see citing works

Source of chronic inflammation in aging

Sanada, F., Taniyama, Y., Muratsu, J., Otsu, R., Shimizu, H., Rakugi, H., & Morishita, R. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00012 · Cited by 413 · see citing works

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 410 · see citing works

The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults

Lewis, D. A., Brown, R. L., Williams, J. P., White, P., Jacobson, S. K., Marchesi, J. R., & Drake, M. J. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00041 · Cited by 387 · see citing works

The Role of Curcumin in Aging and Senescence: Molecular Mechanisms

Zia, A., Farkhondeh, T., Pourbagher-Shahri, A. M., & Samarghandian, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111119 · Cited by 378 · see citing works

Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations

Kugel, C. H., Douglass, S. M., Webster, M. R., Kaur, A., Liu, Q., Yin, X., Weiss, S. A., Darvishian, F., Al-Rohil, R. N., Ndoye, A., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1116 · Cited by 367 · see citing works

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people

Koch, S. D., Larbi, A., Derhovanessian, E., Özcelik, D., Naumova, E. J., & Pawelec, G. (2008) · Immunity & Ageing · doi:10.1186/1742-4933-5-6 · Cited by 360 · see citing works

SARS-CoV-2, COVID-19 and the aging immune system

Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans

Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Žugich, D., Kaye, J., & Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301721 · Cited by 352 · see citing works

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

Schwartz, M., & Baruch, K. (2014) · The EMBO Journal · doi:10.1002/embj.201386609 · Cited by 349 · see citing works

Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders

Barrera, G., Pizzimenti, S., Daga, M., Dianzani, C., Arcaro, A., Cetrangolo, G. P., Giordano, G., Cucci, M. A., Graf, M. E., & Gentile, F. (2018) · Antioxidants · doi:10.3390/antiox7080102 · Cited by 338 · see citing works

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

Horvath, S., Pirazzini, C., Bacalini, M. G., Gentilini, D., Di Blasio, A. M., Delledonne, M., Mari, D., Arosio, B., Monti, D., Passarino, G., et al. (2015) · Aging · doi:10.18632/aging.100861 · Cited by 316 · see citing works

The Role of the Thymus in the Immune Response

Thapa, P., & Färber, D. L. (2019) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2018.12.001 · Cited by 311 · see citing works

DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative

Levine, M. E., Hosgood, H. D., Chen, B. H., Absher, D., Assimes, T. L., & Horvath, S. (2015) · Aging · doi:10.18632/aging.100809 · Cited by 308 · see citing works

Effects of Aging on Fracture Healing

Clark, D. R., Nakamura, M. C., Miclau, T., & Marcucio, R. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0413-9 · Cited by 293 · see citing works

The Immune System and Its Dysregulation with Aging

Müller, L., Benedetto, S. D., & Pawelec, G. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_2 · Cited by 292 · see citing works

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety

Vitanza, N. A., Wilson, A. L., Huang, W., Seidel, K. D., Brown, C., Gustafson, J. A., Yokoyama, J. K., Johnson, A., Baxter, B. A., Koning, R. W., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0750 · Cited by 282 · see citing works

The aging lung

Kovacs, E. J., Lowery, E. M., Kuhlmann, E. A., & Brubaker, A. L. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s51152 · Cited by 280 · see citing works

Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis

Tylutka, A., Walas, Ł., & Zembroń-Łacny, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1330386 · Cited by 279 · see citing works

Evidence of premature immune aging in patients thymectomized during early childhood

Sauce, D., Larsen, M., Fastenackels, S., Duperrier, A., Keller, M., Grubeck-Loebenstein, B., Ferrand, C., Debré, P., Sidi, D., & Appay, V. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39269 · Cited by 278 · see citing works

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

Harries, L. W., Hernandez, D. G., Henley, W., Wood, A. R., Holly, A. C., Bradley-Smith, R. M., Yaghootkar, H., Dutta, A., Murray, A., Frayling, T. M., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00726.x · Cited by 273 · see citing works

Field effectiveness of vaccination against tick-borne encephalitis

Heinz, F. X., Holzmann, H., Essl, A., & Kundi, M. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.08.024 · Cited by 263 · see citing works

Hallmarks of human “immunosenescence”: adaptation or dysregulation?

Pawelec, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-15 · Cited by 257 · see citing works

Inflammageing and metaflammation: The yin and yang of type 2 diabetes

Prattichizzo, F., Nigris, V. D., Spiga, R., Mancuso, E., Sala, L. L., Antonicelli, R., Testa, R., Procopio, A. D., Olivieri, F., & Ceriello, A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.003 · Cited by 249 · see citing works

The inflammation hypothesis in geriatric depression

Alexopoulos, G. S., & Morimoto, S. S. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2672 · Cited by 225 · see citing works

Two-Step Senescence-Focused Cancer Therapies

Sieben, C. J., Sturmlechner, I., van de Sluis, B., & van Deursen, J. M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.04.006 · Cited by 222 · see citing works

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215 · see citing works

Immunosenescence: deficits in adaptive immunity in the elderly

Hakim, F. T., & Gress, R. E. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00891.x · Cited by 215 · see citing works

Immunosenescence, aging and successful aging

Wang, Y., Chen, D., Han, Y., Gu, Z., & Sun, C. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.942796 · Cited by 215 · see citing works

Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy

Watson, N., Ding, B., Zhu, X., & Frisina, R. D. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.002 · Cited by 213 · see citing works

Role of CMV in immune senescence.

Pawelec, G., & Derhovanessian, E. (2011) · Virus Research · doi:10.1016/j.virusres.2010.09.010 · Cited by 201 · see citing works

Human gut microbiota and healthy aging: Recent developments and future prospective

Kumar, M., Babaei, P., Ji, B., & Nielsen, J. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-150002 · Cited by 201 · see citing works

B cells and aging: molecules and mechanisms

Cancro, M. P., Hao, Y., Scholz, J. L., Riley, R. L., Frasca, D., Dunn-Walters, D. K., & Blomberg, B. B. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.005 · Cited by 198 · see citing works

Immune checkpoint inhibitors and elderly people: A review

Daste, A., Domblides, C., Gross‐Goupil, M., Chakiba, C., Quivy, A., Cochin, V., de Monès, E., Larmonier, N., Soubeyran, P., & Ravaud, A. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.05.044 · Cited by 189 · see citing works

Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention

Wu, D., & Meydani, S. N. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108023 · Cited by 187 · see citing works

Molecular and cellular pathways contributing to brain aging

Zia, A., Pourbagher‐Shahri, A. M., Farkhondeh, T., & Samarghandian, S. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00179-9 · Cited by 186 · see citing works

Animal models for SARS and MERS coronaviruses

Gretebeck, L., & Subbarao, K. (2015) · Current Opinion in Virology · doi:10.1016/j.coviro.2015.06.009 · Cited by 181 · see citing works

Differential effects of aging and sex on stroke induced inflammation across the lifespan

Manwani, B., Liu, F., Scranton, V. L., Hammond, M. D., Sansing, L. H., & McCullough, L. D. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.08.011 · Cited by 180 · see citing works

The Role of Cytochromes P450 in Infection

Stavropoulou, E., Pîrcălăbioru, G. G., & Bezirtzoglou, E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00089 · Cited by 178 · see citing works

Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles

Carter, A. J. R., & Nguyen, A. Q. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-160 · Cited by 176 · see citing works

Vaccines for preventing herpes zoster in older adults

Gagliardi, A. M., Andriolo, B. N., Torloni, M. R., & Soares, B. G. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008858.pub3 · Cited by 175 · see citing works

Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4+ T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype

van der Weerd, K., Dik, W. A., Schrijver, B., Schweitzer, D. H., Langerak, A. W., Drexhage, H. A., Kiewiet, R. M., van Aken, M. O., van Huisstede, A., van Dongen, J. J. M., et al. (2012) · Diabetes · doi:10.2337/db11-1065 · Cited by 174 · see citing works

Role of Epicardial Adipose Tissue in Health and Disease: A Matter of Fat?

Gaborit, B., Sengenès, C., Ancel, P., Jacquier, A., & Dutour, A. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160034 · Cited by 174 · see citing works

Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age

Payne, A., Nahashon, S. N., Taka, E., Adinew, G. M., & Soliman, K. F. A. (2022) · Biomolecules · doi:10.3390/biom12030371 · Cited by 171 · see citing works

PneumocystisColonization Is Highly Prevalent in the Autopsied Lungs of the General Population

Ponce, C. A., Gallo, M., Bustamante, R. I., & Vargas, S. L. (2010) · Clinical Infectious Diseases · doi:10.1086/649868 · Cited by 166 · see citing works

B cell maintenance and function in aging

Kogut, I., Scholz, J. L., Cancro, M. P., & Cambier, J. C. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.004 · Cited by 166 · see citing works

Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives

Islam, M. R., Rauf, A., Akash, S., Trisha, S. I., Nasim, A. H., Akter, M., Dhar, P. S., Ogaly, H. A., Hemeg, H. A., Wilairatana, P., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116034 · Cited by 165 · see citing works

The effect of ageing on human lymphocyte subsets: comparison of males and females

Yan, J., Greer, J. M., Hull, R., O’Sullivan, J. D., Henderson, R. D., Read, S. J., & McCombe, P. (2010) · Immunity & Ageing · doi:10.1186/1742-4933-7-4 · Cited by 164 · see citing works

Immunosenenescence: role of cytomegalovirus

Pawelec, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.010 · Cited by 163 · see citing works

Gastro-Intestinal and Oral Microbiome Signatures Associated with Healthy Aging

Singh, H., Torralba, M. G., Moncera, K. J., DiLello, L., Petrini, J., Nelson, K. E., & Pieper, R. (2019) · GeroScience · doi:10.1007/s11357-019-00098-8 · Cited by 158 · see citing works

Age-related decline in immunity: implications for vaccine responsiveness

Kumar, R., & Burns, E. A. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.4.467 · Cited by 156 · see citing works

Reduced naïve <scp>CD</scp> 8 ⁺ <scp>T</scp> ‐cell priming efficacy in elderly adults

Briceño, O., Lissina, A., Wanke, K., Afonso, G., Braun, A., Ragon, K., Miquel, T., Gostick, E., Papagno, L., Stiasny, K., et al. (2016) · Aging Cell · doi:10.1111/acel.12384 · Cited by 151 · see citing works

Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

Rinninella, E., Cintoni, M., Raoul, P. C., Ianiro, G., Laterza, L., Lopetuso, L. R., Ponziani, F. R., Gasbarrini, A., & Mele, M. C. (2020) · Microorganisms · doi:10.3390/microorganisms8081140 · Cited by 151 · see citing works

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

Lee, K. S., Lin, S., Copland, D. A., Dick, A. D., & Liu, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02088-0 · Cited by 150 · see citing works

CD56brightCD16+ NK Cells: A Functional Intermediate Stage of NK Cell Differentiation

Béziat, V., Duffy, D., Nguyen, S., Garff‐Tavernier, M. L., Decocq, J., Combadière, B., Debré, P., & Vieillard, V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100330 · Cited by 150 · see citing works

Accelerated epigenetic aging in Werner syndrome

Maierhofer, A., Flunkert, J., Oshima, J., Martin, G. M., Haaf, T., & Horvath, S. (2017) · Aging · doi:10.18632/aging.101217 · Cited by 150 · see citing works

. Persistent viral infections and immune aging.

Brunner, S., Herndler-Brandstetter, D., Weinberger, B., & Grubeck-Loebenstein, B. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.003 · Cited by 143 · see citing works

Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses

Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110632 · Cited by 143 · see citing works

Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: A retrospective cohort study and review of the literature

Arnson, Y., Amital, H., Agmon‐Levin, N., Alon, D., Sánchez‐Castañón, M., López‐Hoyos, M., Matucci‐Cerinic, M., Szűcs, G., Shapira, Y., Szekanecz, Z., et al. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.02.002 · Cited by 139 · see citing works

Cancer and Aging - the Inflammatory Connection

Zinger, A., Cho, W. C. S., & Ben‐Yehuda, A. (2017) · Aging and Disease · doi:10.14336/ad.2016.1230 · Cited by 137 · see citing works

Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity

Moorlag, S. J. C. F. M., Folkman, L., ter Horst, R., Krausgruber, T., Barreca, D., Schuster, L. C., Fife, V. E. R., Matzaraki, V., Li, W., Reichl, S., et al. (2024) · Immunity · doi:10.1016/j.immuni.2023.12.005 · Cited by 135 · see citing works

Ageing in a eusocial insect: molecular and physiological characteristics of life span plasticity in the honey bee

Münch, D., Amdam, G. V., & Wolschin, F. (2008) · Functional Ecology · doi:10.1111/j.1365-2435.2008.01419.x · Cited by 134 · see citing works

Aging and influenza vaccine-induced immunity

Dugan, H. L., Henry, C., & Wilson, P. C. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103998 · Cited by 133 · see citing works

Body Composition, Changing Physiological Functions and Nutrient Requirements of the Elderly

Elmadfa, I., & Meyer, A. L. (2008) · Annals of Nutrition and Metabolism · doi:10.1159/000115339 · Cited by 132 · see citing works

Mediterranean diet and the hallmarks of ageing

Shannon, O. M., Ashor, A. W., Scialò, F., Saretzki, G. C., Martin-Ruiz, C. M., Lara, J., Matu, J., Griffiths, A., Robinson, N., Lionetti, L., et al. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00841-x · Cited by 131 · see citing works

Impaired Antibody Response to Influenza Vaccine in HIV-Infected and Uninfected Aging Women Is Associated with Immune Activation and Inflammation

Parmigiani, A., Alcaide, M. L., Freguja, R., Pallikkuth, S., Frasca, D., Fischl, M. A., & Pahwa, S. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079816 · Cited by 129 · see citing works

Stem cells and aging in the hematopoietic system

Warren, L. A., & Rossi, D. J. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.010 · Cited by 128 · see citing works

Factors that may impact on immunosenescence: an appraisal

Ongrádi, J., & Kövesdi, V. (2010) · Immunity &amp; Ageing · doi:10.1186/1742-4933-7-7 · Cited by 128 · see citing works

Rhesus macaques as a tractable physiological model of human ageing

Chiou, K. L., Montague, M. J., Goldman, E. A., Watowich, M. M., Sams, S. N., Song, J., Horvath, J. E., Sterner, K. N., Ruiz-Lambides, A. V., Martínez, M. I., et al. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0612 · Cited by 127 · see citing works

The Impact of Immunosenescence on Pulmonary Disease

Murray, M., & Chotirmall, S. H. (2015) · Mediators of Inflammation · doi:10.1155/2015/692546 · Cited by 124 · see citing works

TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases

Balistreri, C., Colonna-Romano, G., Lio, D., Candore, G., & Caruso, C. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9297-5 · Cited by 124 · see citing works

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Bulati, M., Buffa, S., Candore, G., Caruso, C., Dunn‐Walters, D. K., Pellicanò, M., Wu, Y.-C. B., & Romano, G. C. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.12.002 · Cited by 121 · see citing works

Hormonal control of T-cell development in health and disease

Savino, W., Mendes‐da‐Cruz, D. A., Lepletier, A., & Dardenne, M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.168 · Cited by 121 · see citing works

The sequence of disease-modifying therapies in relapsing multiple sclerosis: safety and immunologic considerations

Pardo, G., & Jones, D. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8594-9 · Cited by 119 · see citing works

Why the elderly appear to be more severely affected by <scp>COVID</scp>‐19: The potential role of immunosenescence and <scp>CMV</scp>

Kadambari, S., Klenerman, P., & Pollard, A. J. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2144 · Cited by 118 · see citing works

Aging: Molecular Pathways and Implications on the Cardiovascular System

de Almeida, A. J. P. O., Ribeiro, T. P., & de Medeiros, I. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7941563 · Cited by 117 · see citing works

Zinc and its role in age‐related inflammation and immune dysfunction

Wong, C. P., & Ho, E. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100511 · Cited by 113 · see citing works

The confounded effects of age and exposure history in response to influenza vaccination

Mosterín, A., McElhaney, J. E., Fonville, J. M., Powers, D. C., BEYER, W. E. P., & Smith, D. J. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.11.058 · Cited by 112 · see citing works

Zinc, Vitamin D and Vitamin C: Perspectives for COVID-19 With a Focus on Physical Tissue Barrier Integrity

Name, J. J., Souza, A. C. R., Vasconcelos, A. R., Prado, P. S., & Pereira, C. P. M. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.606398 · Cited by 112 · see citing works

Development of adjuvanted recombinant zoster vaccine and its implications for shingles prevention

Lecrenier, N., Beukelaers, P., Colindres, R. E., Curran, D., Kesel, C. D., Saegher, J.-P. D., Didierlaurent, A. M., Ledent, E., Mols, J., Mrkvan, T., et al. (2018) · Expert Review of Vaccines · doi:10.1080/14760584.2018.1495565 · Cited by 110 · see citing works

Age-related deregulation of naive T cell homeostasis in elderly humans

Ferrando‐Martínez, S., Ruíz-Mateos, E., Hernández, A., Gutiérrez, E., Rodríguez-Méndez, M. M., Ordóñez, A., & Leal, M. (2010) · AGE · doi:10.1007/s11357-010-9170-8 · Cited by 109 · see citing works

HPV vaccination against cervical cancer in women above 25 years of age: key considerations and current perspectives

Castellsagué, X., Schneider, A., Kaufmann, A. M., & Bosch, F. X. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2009.09.021 · Cited by 108 · see citing works

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

Conley, M. N., Wong, C. P., Duyck, K. M., Hord, N. G., Ho, E., & Sharpton, T. J. (2016) · PeerJ · doi:10.7717/peerj.1854 · Cited by 108 · see citing works

A thymus-centric perspective on immune ageing: Mechanisms, cross-species insights, and therapeutic directions

Mironenkov, A., Zhu, J., & Lu, Y. (2025) · Ageing and Cancer Research & Treatment · doi:10.70401/acrt.2025.0008

Immunosenescence : ageing of the immune system : review

Suchard, M. S. (2015) · Pharmacy management

Immunosenescence : ageing of the immune system : review

Suchard, M. S. (2015) · Pharmacy management · Cited by 5 · see citing works

Development of immunosenescence

Han, H., Zhang, J., & Wang, Y. (2008) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2008.02.013

Changes within the immune system from Birth to Old Age

Grubeck-Loebenstein, B., & Herndler-Brandstetter, D. (2008) · Oesterreichisches Musiklexikon online (Institut für kunst- und musikhistorische Forschungen der Österreichischen Akademie der Wissenschaften)