The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING*
Abstract
▪ Abstract The development of B lymphocytes is a highly regulated process that depends in part on lineage-specific cell surface molecules. In addition, transmembrane signals generated through the B cell antigen receptor and other surface molecules regulate B cell responses to foreign antigens. Recent studies reveal CD22 to be a functionally significant receptor during these processes. CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 is a member of the Ig superfamily that serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. CD22 signaling is mediated via interactions with a number of kinases and phosphatases that bind the cytoplasmic domain through phosphorylated tyrosine residues located within consensus TAM and TIM motifs. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. Most notable in CD22-deficient mice is a significant diminution of surface Ig levels in these B cell subpopulations, which suggests that CD22 functions in vivo to adjust the signaling threshold of cell surface antigen receptors. A further understanding of CD22 function is required and may reveal roles for CD22 in disease susceptibility or the development of autoimmunity.
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Citations
Cites
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Self-citationA Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP
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Cited by
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
Depuydt, M. A. C., Prange, K. H. M., Slenders, L., Örd, T., Elbersen, D., Boltjes, A., de Jager, S. C. A., Asselbergs, F. W., de Borst, G. J., Aavik, E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316770 · Cited by 594
(2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.00607.x · Cited by 472
Siglecs as Immune Cell Checkpoints in Disease
Duan, S., & Paulson, J. C. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102419-035900 · Cited by 452
Tedder, T. F., Inaoki, M., & Sato, S. (1997) · Immunity · doi:10.1016/s1074-7613(00)80418-5 · Cited by 383
Self-citationRole of B cells as antigen presenting cells
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352
Metadata
- Authors
- Tedder, T. F., Tuscano, J., Sato, S., & Kehrl, J. H.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1997-04
- Volume
- 15
- Issue
- 1
- Pages
- 481-504
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2150235363
- Cited by
- 300
- References
- 80
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING*. https://app.cochat.ai/papers/10.1146/annurev.immunol.15.1.481
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- Tedder, T. F., Tuscano, J., Sato, S., & Kehrl, J. H. (1997). CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING*. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.15.1.481
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