Role of B cells as antigen presenting cells
Open accessAbstract
B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory response against pathogens, B cells are also capable of generating cell-mediated immunity. It has been demonstrated by several groups that B cells can activate antigen-specific CD4 and CD8 T cells, and can have regulatory and cytotoxic effects. The function of B cells as professional antigen presenting cells (APCs) to activate T cells has been largely understudied. This, however, requires attention as several recent reports have demonstrated the importance of B cells within the tumor microenvironment, and B cells are increasingly being evaluated as cellular therapies. Antigen presentation through B cells can be through antigen-specific (B cell receptor (BCR) dependent) or antigen non-specific (BCR independent) mechanisms and can be modulated by a variety of intrinsic and external factors. This review will discuss the pathways and mechanisms by which B cells present antigens, and how B cells differ from other professional APCs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
B cells produce cytokines and contribute to T cell activation through antigen presentation, which can shape overall immune responses.
“In addition, B cells produce cytokines and contribute to T cell activation through antigen presentation which can shape the overall immune responses [41,42].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [42]
B cells are a crucial component of the adaptive immune system, responsible for producing antibodies and providing defense against infectious agents.
“B cells are a crucial component of the adaptive immune system, responsible for producing antibodies, providing an important line of defense against infectious agents.”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer
Bindea, G., Mlecnik, B., Tosolini, M., Kirilovsky, A., Waldner, M. J., Obenauf, A. C., Angell, H. K., Fredriksen, T., Lafontaine, L., Berger, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.003 · Cited by 4,390 · see citing works
T cell receptor antagonist peptides induce positive selection.
Hogquist, K., Jameson, S., Heath, W., Howard, J. L., Bevan, M., & Carbone, F. (1994) · Cell · doi:10.1016/0092-8674(94)90169-4 · Cited by 3,252 · see citing works
Molecular mechanisms of T cell co-stimulation and co-inhibition
Chen, L., & Flies, D. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3405 · Cited by 3,114 · see citing works
B cells and tertiary lymphoid structures promote immunotherapy response
Helmink, B. A., Reddy, S. M., Gao, J., Zhang, S., Basar, R., Thakur, R., Yizhak, K., Sade-Feldman, M., Blando, J., Han, G., et al. (2020) · Nature · doi:10.1038/s41586-019-1922-8 · Cited by 2,731 · cited 1× · see citing works
“Several groups have also shown that the presence of TLS is associated with response to immune checkpoint blockade (11, 13, 14).”
BackgroundTertiary lymphoid structures improve immunotherapy and survival in melanoma
Cabrita, R., Lauss, M., Sanna, A., Donia, M., Skaarup Larsen, M., Mitra, S., Johansson, I., Phung, B., Harbst, K., Vallon-Christersson, J., et al. (2020) · Nature · doi:10.1038/s41586-019-1914-8 · Cited by 2,374 · see citing works
Antigen presentation and T cell stimulation by dendritic cells.
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 2,106 · see citing works
B cells are associated with survival and immunotherapy response in sarcoma
Petitprez, F., de Reyniès, A., Keung, E. Z., Chen, T. W.-W., Sun, C.-M., Calderaro, J., Jeng, Y.-M., Hsiao, L.-P., Lacroix, L., Bougoüin, A., et al. (2020) · Nature · doi:10.1038/s41586-019-1906-8 · Cited by 1,942 · see citing works
T follicular helper cell differentiation, function, and roles in disease
Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847 · see citing works
The Instructive Role of Innate Immunity in the Acquired Immune Response
Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,718 · see citing works
B cells regulate autoimmunity by provision of IL-10
Fillatreau, S., Sweenie, C. H., McGeachy, M. J., Gray, D., & Anderton, S. M. (2002) · Nature Immunology · doi:10.1038/ni833 · Cited by 1,647 · see citing works
Cross-presentation by dendritic cells
Joffre, O. P., Segura, É., Savina, A., & Amigorena, S. (2012) · Nature reviews. Immunology · doi:10.1038/nri3254 · Cited by 1,646 · see citing works
Molecular mechanism and function of CD40/CD40L engagement in the immune system
Elgueta, R., Benson, M. J., de Vries, V. C., Wasiuk, A., Guo, Y., & Noelle, R. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00782.x · Cited by 1,633 · see citing works
Pathways of Antigen Processing
Blum, J. S., Wearsch, P. A., & Cresswell, P. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095910 · Cited by 1,561 · see citing works
Regulatory B Cells: Origin, Phenotype, and Function
Rosser, E. C., & Mauri, C. (2015) · Immunity · doi:10.1016/j.immuni.2015.04.005 · Cited by 1,455 · see citing works
The generation of antibody-secreting plasma cells
Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3795 · Cited by 1,446 · see citing works
Immune regulatory function of B cells.
Mauri, C., & Bosma, A. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074934 · Cited by 1,278 · see citing works
The ins and outs of MHC class II-mediated antigen processing and presentation
Roche, P. A., & Furuta, K. (2015) · Nature reviews. Immunology · doi:10.1038/nri3818 · Cited by 1,207 · see citing works
Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141 · see citing works
Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
Chen, S., Sims, G. P., Chen, X. X., Gu, Y. Y., Chen, S., & Lipsky, P. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1634 · Cited by 1,119 · see citing works
Mechanism and Regulation of Class Switch Recombination
Stavnezer, J., Guikema, J. E. J., & Schrader, C. E. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090248 · Cited by 1,117 · see citing works
Mechanisms and functional significance of tumour-induced dendritic-cell defects
Gabrilovich, D. I. (2004) · Nature reviews. Immunology · doi:10.1038/nri1498 · Cited by 1,022 · see citing works
Wieczorek, M., Abualrous, E. T., Sticht, J., Álvaro‐Benito, M., Stolzenberg, S., Noé, F., & Freund, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00292 · Cited by 998 · see citing works
Germinal-Center Organization and Cellular Dynamics
Allen, C. D. C., Okada, T., & Cyster, J. G. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.009 · Cited by 986 · see citing works
Sabat, R., Grütz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., & Geginat, J. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.09.002 · Cited by 977 · see citing works
B Cell Responses: Cell Interaction Dynamics and Decisions
Cyster, J. G., & Allen, C. D. C. (2019) · Cell · doi:10.1016/j.cell.2019.03.016 · Cited by 974 · see citing works
Germain, C., Gnjatic, S., Tamzalit, F., Knockaert, S., Remark, R., Goc, J., Lepelley, A., Becht, E., Katsahian, S., Bizouard, G., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1611oc · Cited by 833 · see citing works
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
de Visser, K. E., Korets, L. V., & Coussens, L. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.014 · Cited by 826 · see citing works
Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate
Delamarre, L., Pack, M., Chang, H. C., Mellman, I., & Trombetta, E. S. (2005) · Science · doi:10.1126/science.1108003 · Cited by 776 · see citing works
The who, how and where of antigen presentation to B cells
Batista, F. D., & Harwood, N. E. (2008) · Nature reviews. Immunology · doi:10.1038/nri2454 · Cited by 775 · see citing works
BAFF: A fundamental survival factor for B cells
Mackay, F., & Browning, J. L. (2002) · Nature reviews. Immunology · doi:10.1038/nri844 · Cited by 744 · see citing works
Olkhanud, P. B., Damdinsuren, B., Bodogai, M., Gress, R. E., Sen, R., Wejksza, K., Malchinkhuu, E., Wersto, R. P., & Biragyn, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4316 · Cited by 689 · see citing works
A Role for CD40 Expression on CD8 + T Cells in the Generation of CD8 + T Cell Memory
Bourgeois, C., Rocha, B., & Tanchot, C. (2002) · Science · doi:10.1126/science.1072615 · Cited by 641 · see citing works
Revisiting IL-2: Biology and therapeutic prospects
Abbas, A. K., Trotta, E., Simeonov, D. R., Marson, A., & Bluestone, J. A. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat1482 · Cited by 631 · see citing works
Haas, K. M., Poe, J. C., Steeber, D. A., & Tedder, T. F. (2005) · Immunity · doi:10.1016/j.immuni.2005.04.011 · Cited by 628 · see citing works
B cell memory: building two walls of protection against pathogens
Akkaya, M., Kwak, K., & Pierce, S. K. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0244-2 · Cited by 626 · see citing works
Inflammatory cytokines as a third signal for T cell activation
Curtsinger, J., & Mescher, M. F. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.02.013 · Cited by 618 · see citing works
Carrasco, Y. R., & Batista, F. D. (2007) · Immunity · doi:10.1016/j.immuni.2007.06.007 · Cited by 611 · see citing works
Baumgarth, N., Herman, O. C., Jager, G. C., Brown, L. E., Herzenberg, L. A., & Chen, J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.271 · Cited by 583 · see citing works
Delineation of the Thymic and Bursal Lymphoid Systems in the Chicken
Cooper, M. D., Peterson, R. D. A., & Good, R. A. (1965) · Nature · doi:10.1038/205143a0 · Cited by 579 · see citing works
Nielsen, J. S., Sahota, R. A., Milne, K., Kost, S. E. F., Nesslinger, N. J., Watson, P. H., & Nelson, B. H. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0234 · Cited by 554 · see citing works
Caldéraro, J., Petitprez, F., Becht, É., Laurent, A., Hirsch, T. Z., Rousseau, B., Luciani, A., Amaddeo, G., Derman, J., Charpy, C., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.09.003 · Cited by 480 · see citing works
B cells inhibit induction of T cell-dependent tumor immunity
Qin, Z.-H., Richter, G., Schüler, T., Ibe, S., Cao, X.-T., & Blankenstein, T. (1998) · Nature Medicine · doi:10.1038/nm0598-627 · Cited by 440 · see citing works
Toll‐like receptor stimulation as a third signal required for activation of human naive B cells
Ruprecht, C. R., & Lanzavecchia, A. (2006) · European Journal of Immunology · doi:10.1002/eji.200535744 · Cited by 436 · see citing works
TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity
Lampropoulou, V., Hoehlig, K., Roch, T., Neves, P., Gómez, E. C., Sweenie, C. H., Hao, Y., Freitas, A. A., Steinhoff, U., Anderton, S. M., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4763 · Cited by 436 · cited 1× · see citing works
“Several B cell subsets, such as immature B cells, plasmablasts and mature B cells, have been shown to differentiate into IL-10-producing Bregs, upon stimulation with toll-like receptors (TLRs) and/or CD40 activation (93, 94).”
BackgroundMHC class I antigen presentation: learning from viral evasion strategies
Hansen, T. H., & Bouvier, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2575 · Cited by 427 · see citing works
Takeda, K., & Akira, S. (2015) · Current Protocols in Immunology · doi:10.1002/0471142735.im1412s109 · Cited by 422 · see citing works
B cells responses and cytokine production are regulated by their immune microenvironment
Vazquez, M. I., Catalan-Dibene, J., & Zlotnik, A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.007 · Cited by 421 · see citing works
Current Concepts of Antigen Cross-Presentation
Embgenbroich, M., & Burgdorf, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01643 · Cited by 403 · see citing works
Liang, F., Lindgren, G., Lin, A., Thompson, E. A., Ols, S., Röhss, J., John, S., Hassett, K., Yuzhakov, O., Bahl, K., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.08.006 · Cited by 395 · see citing works
Stuber, E. R., Neurath, M. F., Calderhead, D. M., Fell, H. P., & Strober, W. (1995) · Immunity · doi:10.1016/1074-7613(95)90031-4 · Cited by 391 · see citing works
Mingari, M. C., Gerosa, F., Carra, G., Accolla, R. S., Moretta, A., Zubler, R. H., Waldmann, T. A., & Moretta, L. (1984) · Nature · doi:10.1038/312641a0 · Cited by 376 · see citing works
Oliver, A. M., Martin, F., & Kearney, J. F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.12.7198 · Cited by 367 · see citing works
Schultze, J. L., Michalak, S., Seamon, M. J., Dranoff, G., Jung, K., Daley, J., Delgado, J. C., Gribben, J. G., & Nadler, L. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119822 · Cited by 355 · see citing works
B-1 B Cell Development in the Fetus and Adult
Montecino‐Rodriguez, E., & Dorshkind, K. A. (2012) · Immunity · doi:10.1016/j.immuni.2011.11.017 · Cited by 353 · see citing works
Tumor-infiltrating B cells signal functional humoral immune responses in breast cancer
Garaud, S., Buisseret, L., Solinas, C., Gu‐Trantien, C., de Wind, A., den Eynden, G. V., Naveaux, C., Lodewyckx, J., Boisson, A., Duvillier, H., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.129641 · Cited by 349 · see citing works
Carrasco, Y. R., Fleire, S. J., Cameron, T. O., Dustin, M. L., & Batista, F. D. (2004) · Immunity · doi:10.1016/s1074-7613(04)00105-0 · Cited by 345 · see citing works
Ise, W., Fujii, K., Shiroguchi, K., Ito, A., Kometani, K., Takeda, K., Kawakami, E., Yamashita, K., Suzuki, K., Okada, T., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.027 · Cited by 324 · see citing works
Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM
Boes, M. L., Esau, C., Fischer, M. B., Schmidt, T., Carroll, M. C., & Chen, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4776 · Cited by 323 · see citing works
Role of 4-1BB in immune responses
Vinay, D. S., & Kwon, B. S. (1998) · Seminars in Immunology · doi:10.1006/smim.1998.0157 · Cited by 313 · see citing works
How B cells capture, process and present antigens: a crucial role for cell polarity
Yuseff, M.-I., Pierobon, P., Reversat, A., & Lennon‐Duménil, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3469 · Cited by 308 · see citing works
Bruno, T. C., Ebner, P. J., Moore, B. L., Squalls, O., Waugh, K. A., Eruslanov, E. B., Singhal, S. K., Mitchell, J. D., Franklin, W. A., Merrick, D. T., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0075 · Cited by 302 · see citing works
CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING*
Tedder, T. F., Tuscano, J. M., Sato, S., & Kehrl, J. H. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.481 · Cited by 300 · see citing works
B cells as antigen presenting cells
Rodríguez‐Pinto, D. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2006.02.005 · Cited by 299 · see citing works
Hong, S., Zhang, Z., Liu, H., Tian, M., Zhu, X., Zhang, Z., Wang, W., Zhou, X., Zhang, F., Ge, Q., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.012 · Cited by 298 · see citing works
Interleukin 13 is a B cell stimulating factor.
Defrance, T., Carayon, P., Billian, G., Guillemot, J.-C., Minty, A. J., Caput, D., & Ferrara, P. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.1.135 · Cited by 294 · see citing works
Stuber, E. R., & Strober, W. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.979 · Cited by 286 · see citing works
Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells
Futagawa, T., Akiba, H., Kodama, T., Takeda, K., Hosoda, Y., Yagita∥, H., & Okumura, K. (2002) · International Immunology · doi:10.1093/intimm/14.3.275 · Cited by 283 · see citing works
Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand
Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L. C., Nose, M., Noda, T., & Sugamura, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.2.365 · Cited by 281 · see citing works
Transitional B cells: step by step towards immune competence
Chung, J. B., Silverman, M. A., & Monroe, J. G. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00119-4 · Cited by 264 · see citing works
Matsumoto, M., Fujii, Y., Baba, A., Hikida, M., Kurosaki, T., & Baba, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.016 · Cited by 262 · see citing works
Parekh, V., Prasad, D. V., Banerjee, P., Joshi, B., Kumar, A., & Mishra, G. C. (2003) · Journal of Immunology · doi:10.4049/jimmunol.170.12.5897 · Cited by 246 · see citing works
Shi, J.-Y., Gao, Q., Wang, Z., Zhou, J., Wang, X., Min, Z., Shi, Y., Shi, G., Ding, Z., Ke, A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3497 · Cited by 240 · see citing works
Distinct Role of CD80 and CD86 in the Regulation of the Activation of B Cell and B Cell Lymphoma
Suvas, S., Singh, V., Sahdev, S., Vohra, H., & Agrewala, J. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105902200 · Cited by 239 · see citing works
TGF‐β‐producing regulatory B cells induce regulatory T cells and promote transplantation tolerance
Lee, K. M., Stott, R. T., Zhao, G., Soohoo, J., Xiong, W., Lian, M., Fitzgerald, L. A., Shi, S., Akrawi, E., Lei, J., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201344062 · Cited by 238 · see citing works
Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Denzin, L. K., Sant’Angelo, D. B., Hammond, C., Surman, M. J., & Cresswell, P. (1997) · Science · doi:10.1126/science.278.5335.106 · Cited by 234 · see citing works
Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage
Moens, L., & Tangye, S. G. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00065 · Cited by 232 · see citing works
B cells expressing cd5 are increased in sjögren's syndrome
Dauphinée, M. J., Tovar, Z., & Talal, N. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310509 · Cited by 230 · see citing works
Hennequin, A., Dérangère, V., Boidot, R., Apétoh, L., Vincent, J., Orry, D., Fraisse, J., Causeret, S., Martin, F., Arnould, L., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1054598 · Cited by 228 · see citing works
Rosalia, R. A., Quakkelaar, E. D., Redeker, A., Khan, S., Camps, M. G. M., Drijfhout, J. W., Silva, A. L., Jiskoot, W., van Hall, T., van Veelen, P. A., et al. (2013) · European Journal of Immunology · doi:10.1002/eji.201343324 · Cited by 217 · see citing works
Sandel, P. C., & Monroe, J. G. (1999) · Immunity · doi:10.1016/s1074-7613(00)80029-1 · Cited by 211 · see citing works
Kamphorst, A. O., Guermonprez, P., Dudziak, D., & Nussenzweig, M. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001205 · Cited by 208 · see citing works
Prognostic impact of B-cell density in cutaneous melanoma
Ladányi, A., Kiss, J., Mohos, A., Somlai, B., Liszkay, G., Gilde, K., Fejôs, Z., Gaudi, I., Dobos, J., & Tı́már, J. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1071-x · Cited by 201 · see citing works
Antigen processing and presentation
(2019) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.07.005 · Cited by 194 · see citing works
Effects of interleukin-2 in immunostimulation and immunosuppression
Pol, J. G., Caudana, P., Paillet, J., Piaggio, E., & Kroemer, G. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20191247 · Cited by 193 · see citing works
Lapointe, R., Bellemare‐Pelletier, A., Housseau, F., Thibodeau, J., & Hwu, P. (2003) · PubMed · Cited by 189 · see citing works
The CD40–CD154 interaction in B cell–T cell liaisons
Bishop, G. A., & Hostager, B. S. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00024-8 · Cited by 188 · see citing works
Nakayama, T., Hieshima, K., Nagakubo, D., Sato, E., Nakayama, M., Kawa, K., & Yoshie, O. (2004) · Journal of Virology · doi:10.1128/jvi.78.4.1665-1674.2004 · Cited by 184 · see citing works
Novel regulation of MHC class II function in B cells
Matsuki, Y., Ohmura‐Hoshino, M., Gotō, E., Aoki, M., Mito-Yoshida, M., Uematsu, M., Hasegawa, T., Koseki, H., Ohara, O., Nakayama, M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601556 · Cited by 183 · see citing works
Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue
Qi, H., Kastenmüller, W., & Germain, R. N. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013254 · Cited by 180 · see citing works
Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets
Gutiérrez-Martínez, E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00363 · Cited by 177 · see citing works
B cells are generated throughout life in humans
Núnêz, C., Nishimoto, N., Gartland, G. L., Billips, L. G., Burrows, P. D., Kubagawa, H., & Cooper, M. D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.2.866 · Cited by 174 · see citing works
Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptor subtypes
Harizi, H., Grosset, C. F., & Gualde, N. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.1002483 · Cited by 172 · see citing works
Antigen Presentation to B Cells
Heesters, B. A., van der Poel, C. E., Das, A., & Carroll, M. C. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.10.003 · Cited by 172 · see citing works
Zhou, X., Su, Y., Lao, X., Liang, Y., & Liao, G. (2015) · Oral Oncology · doi:10.1016/j.oraloncology.2015.11.003 · Cited by 172 · see citing works
Hirano, N., Butler, M. O., Xia, Z., Ansén, S., von Bergwelt‐Baildon, M. S., Neuberg, D. S., Freeman, G. J., & Nadler, L. M. (2005) · Blood · doi:10.1182/blood-2005-05-2073 · Cited by 168 · see citing works
Lim, T. S., Goh, J. C. H., Mortellaro, A., Lim, C. T., Hämmerling, G. J., & Ricciardi‐Castagnoli, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045185 · Cited by 167 · see citing works
IL-21: An Executor of B Cell Fate
Konforte, D., Simard, N. N., & Paige, C. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803009 · Cited by 165 · see citing works
B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis
Yang, C., Lee, H., Pal, S. K., Jové, V., Deng, J., Zhang, W., Hoon, D. S. �., Wakabayashi, M. T., Forman, S. J., & Yu, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064159 · Cited by 165 · see citing works
The regulatory network behind MHC class I expression
Jongsma, M. L. M., Guarda, G., & Spaapen, R. M. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.12.005 · Cited by 162 · see citing works
Takeda, K., & Akira, S. (2007) · Current Protocols in Immunology · doi:10.1002/0471142735.im1412s77 · Cited by 161 · see citing works
Jiang, W., Lederman, M. M., Harding, C. V., Rodriguez, B. A., Mohner, R. J., & Sieg, S. F. (2007) · European Journal of Immunology · doi:10.1002/eji.200636984 · Cited by 157 · see citing works
The Other Function: Class II-Restricted Antigen Presentation by B Cells
Adler, L. N., Jiang, W., Bhamidipati, K., Millican, M., Macaubas, C., Hung, S.-C., & Mellins, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00319 · Cited by 153 · see citing works
Antigen Presentation by MHC-Dressed Cells
NAKAYAMA, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00672 · Cited by 145 · see citing works
The role of B lymphocytes as antigen-presenting cells
Chen, X., & Jensen, P. E. (2008) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-008-0014-5 · Cited by 144 · see citing works
Class II MHC peptide loading by the professionals
Bryant, P. W., & Ploegh, H. L. (2003) · Current Opinion in Immunology · doi:10.1016/j.coi.2003.11.011 · Cited by 144 · see citing works
CpG-DNA Aided Cross-Priming by Cross-Presenting B Cells
Heit, A., Huster, K. M., Schmitz, F., Schiemann, M., Busch, D. H., & Wagner, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1501 · Cited by 141 · see citing works
Barr, T., Brown, S., Mastroeni, P., & Gray, D. (2010) · Journal of Immunology · doi:10.4049/jimmunol.1001431 · Cited by 140 · see citing works
Coughlin, C. M., Vance, B. A., Grupp, S. A., & Vonderheide, R. H. (2003) · Blood · doi:10.1182/blood-2003-07-2379 · Cited by 139 · see citing works
Antigens Varying in Affinity for the B Cell Receptor Induce Differential B Lymphocyte Responses
Kouskoff, V., Famiglietti, S. J., Lacaud, G., Lang, P., Rider, J. E., Kay, B. K., Cambier, J. C., & Nemazee, D. A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.8.1453 · Cited by 138 · see citing works
Antigen affinity discrimination is an intrinsic function of the B cell receptor
Liu, W., Meckel, T., Tolar, P., Sohn, H. W., & Pierce, S. K. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092123 · Cited by 131 · see citing works
Petro, J. B., Gerstein, R. M., Lowe, J. A., III, Carter, R. S., Shinners, N. P., & Khan, W. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200305200 · Cited by 128 · see citing works
Regulatory B cells contribute to the impaired antitumor immunity in ovarian cancer patients
Wei, X. L., Jin, Y., Tian, Y., Zhang, H., Wu, J., Lü, W., & Lu, X. (2015) · Tumor Biology · doi:10.1007/s13277-015-4538-0 · Cited by 128 · see citing works
Novel functions of murine B 1 cells: Active phagocytic and microbicidal abilities
Gao, J., Ma, X., Gu, W., Fu, M., An, J., Xing, Y., Gao, T., Li, W., & Liu, Y. (2012) · European Journal of Immunology · doi:10.1002/eji.201141519 · Cited by 127 · see citing works
The role of BAFF in immune function and implications for autoimmunity
Kalled, S. L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00219.x · Cited by 126 · see citing works
Lankar, D., Vincent-Schneider, H., Briken, V., Yokozeki, T., Raposo, G., & Bonnerot, C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011543 · Cited by 125 · see citing works
Comparison of human B cell activation by TLR7 and TLR9 agonists
Hanten, J. A., Vasilakos, J. P., Riter, C. L., Neys, L., Lipson, K. E., Alkan, Ş. Ş., & Birmachu, W. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-39 · Cited by 121 · see citing works
B lymphocyte activation by contact-mediated interactions with T lymphocytes
Bishop, G. A., & Hostager, B. S. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00216-8 · Cited by 120 · see citing works
Expression of Lyt-1 antigen on certain murine B cell lymphomas.
Lanier, L. L., Warner, N. L., Ledbetter, J. A., & Herzenberg, L. A. (1981) · The Journal of Experimental Medicine · doi:10.1084/jem.153.4.998 · Cited by 120 · see citing works
Johnson, B. F., Clay, T. M., Hobeika, A. C., Lyerly, H. K., & Morse, M. A. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.4.449 · Cited by 119 · see citing works
Montes, C. L., Rodríguez, E. V. A., Merino, M. C., Bermejo, D. A., & Gruppi, A. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407214 · Cited by 117 · see citing works
Expression of toll-like receptors on B lymphocytes
Dasari, P., Nicholson, I., Hodge, G. L., Dandie, G. W., & Zola, H. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.08.020 · Cited by 116 · see citing works
B Cell-Based Cancer Immunotherapy
Wennhold, K., Shimabukuro‐Vornhagen, A., & von Bergwelt‐Baildon, M. (2019) · Transfusion Medicine and Hemotherapy · doi:10.1159/000496166 · Cited by 116 · see citing works
The role of B cell antigen presentation in the initiation of CD4+ T cell response
Hua, Z., & Hou, B. (2020) · Immunological Reviews · doi:10.1111/imr.12859 · Cited by 115 · see citing works
The Role of Regulatory B Cells in Health and Diseases: A Systemic Review
Abebe, E. C., Dejenie, T. A., Ayele, T. M., Baye, N. D., Teshome, A. A., & Muche, Z. T. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s286426 · Cited by 114 · see citing works
Purkerson, J. M., & Isakson, P. C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.4.973 · Cited by 113 · see citing works
The Surprising Discovery That TGFβ Specifically Induces the IgA Class Switch
Stavnezer, J., & Kang, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.5 · Cited by 113 · see citing works
Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes
Wagner, D. H., Vaitaitis, G. M., Sanderson, R. J., Poulin, M., Dobbs, C. M., & HASKINS, K. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052247099 · Cited by 112 · see citing works
Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells
Avalos, A. M., & Ploegh, H. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00092 · Cited by 112 · see citing works
B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses
Rossetti, R. A. M., Lorenzi, N. P. C., Yokochi, K., Rosa, M. B. S. D. F., Benevides, L., Margarido, P. F. R., Baracat, E. C., Carvalho, J. P., Villa, L. L., & Lepique, A. P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199034 · Cited by 112 · see citing works
Subramaniam, K. S., Datta, K., Quintero, E. A., Manix, C., Marks, M. S., & Pirofski, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901638 · Cited by 110 · see citing works
Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid
Hillemanns, P., Untch, M., Dannecker, C., Baumgartner, R., Stepp, H. G., Diebold, J., Weingandt, H., Pr�ve, F., & Korell, M. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000301)85:5 · Cited by 110 · see citing works
Bossie, A., & Vitetta, E. S. (1991) · Cellular Immunology · doi:10.1016/0008-8749(91)90257-c · Cited by 109 · see citing works
Maecker, H. T., Do, M., & Levy, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2458 · Cited by 102 · see citing works
Diversity in MHC class II antigen presentation
Robinson, J. H., & von Delwig, A. A. (2002) · Immunology · doi:10.1046/j.0019-2805.2001.01358.x · Cited by 100 · see citing works
Fujiwara, H., Melenhorst, J. J., Ouriaghli, F. E., Kajigaya, S., Grube, M., Sconocchia, G., Rezvani, K., Price, D. A., Hensel, N. F., Douek, D. C., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2363 · Cited by 98 · see citing works
B‐cell antigen‐receptor signalling in lymphocyte development
Wang, L. D., & Clark, M. R. (2003) · Immunology · doi:10.1111/j.1365-2567.2003.01756.x · Cited by 97 · see citing works
CD83 Modulates B Cell Activation and Germinal Center Responses
Krzyzak, L., Seitz, C., Urbat, A., Hutzler, S., Ostalecki, C., Gläsner, J., Hiergeist, A., Gessner, A., Winkler, T., Steinkasserer, A., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502163 · Cited by 96 · see citing works
Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
Hughes, C. E., Benson, R. A., Bedaj, M., & Maffia, P. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00481 · Cited by 88 · see citing works
Thymus machinery for T-cell selection
Kondo, K., Ohigashi, I., & Takahama, Y. (2018) · International Immunology · doi:10.1093/intimm/dxy081 · Cited by 87 · see citing works
Gonzalez, D. G., Cote, C. M., Patel, J. R., Smith, C. B., Zhang, Y., Nickerson, K. M., Zhang, T., Kerfoot, S. M., & Haberman, A. M. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1500497 · Cited by 83 · see citing works
Germinal Center B Cells Regulate Their Capability to Present Antigen by Modulation of HLA-DO
Glazier, K. S., Hake, S. B., Tobin, H. M., Chadburn, A., Schattner, E. J., & Denzin, L. K. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012059 · Cited by 82 · see citing works
Wong, S. C., Oh, E. C. T., Ng, C.-H., & Lam, K. (2003) · Blood · doi:10.1182/blood-2002-08-2416 · Cited by 81 · see citing works
CD40 ligation in B cell activation, isotype switching and memory development
Gray, D., Siepmann, K., & Wohlleben, G. (1994) · Seminars in Immunology · doi:10.1006/smim.1994.1039 · Cited by 81 · see citing works
Biagi, E., Rousseau, R. F., Yvon, E. S., Schwartz, M. A., Dotti, G., Foster, A. E., Havlik-Cooper, D., Grilley, B., Gee, A. P., Baker, K. R., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0484 · Cited by 80 · see citing works
Andjelić, S., Hsia, C. Y., Suzuki, H., Kadowaki, T., Koyasu, S., & Liou, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3860 · Cited by 79 · see citing works
Sato, T., Ishikawa, S., Akadegawa, K., Ito, T., Yurino, H., Kitabatake, M., Yoneyama, H., & Matsushima, K. (2004) · European Journal of Immunology · doi:10.1002/eji.200425373 · Cited by 77 · see citing works
Sørenmo, K. U., Krick, E., Coughlin, C. M., Overley, B., Gregor, T. P., Vonderheide, R. H., & Mason, N. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024167 · Cited by 75 · see citing works
Cytokines Involved in B-Cell Differentiation and Their Sites of Action
Takatsu, K. (1997) · Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine · doi:10.3181/00379727-215-44119 · Cited by 75 · see citing works
Molecular mechanisms guiding late stages of B‐cell development
Rolink, A., Andersson, J., & Melchers, F. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0101.x · Cited by 74 · see citing works
Carpenter, E. L., Mick, R., Rüter, J., & Vonderheide, R. H. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-93 · Cited by 74 · see citing works
Lee-Chang, C., Miska, J. M., Hou, D., Rashidi, A., Zhang, P., Burga, R. A., Jusué-Torres, I., Xiao, T., Arrieta, V. A., Zhang, D. Y., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200913 · Cited by 73 · see citing works
B ‐cell‐intrinsic STAT 6 signaling controls germinal center formation
Turqueti‐Neves, A., Otte, M., da Costa, O. P., Höpken, U. E., Lipp, M., Buch, T., & Voehringer, D. (2014) · European Journal of Immunology · doi:10.1002/eji.201344203 · Cited by 73 · see citing works
The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway
Schulze, M. E. D., & Wucherpfennig, K. W. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.11.004 · Cited by 73 · see citing works
IFN-α amplifies human naïve B cell TLR-9-mediated activation and Ig production
Giordani, L., Sanchez, M., Libri, I., Quaranta, M. G., Mattioli, B., & Viora, M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0908560 · Cited by 72 · see citing works
Sorrentino, R., Morello, S., Forte, G., Montinaro, A., Vita, G. D., Luciano, A., Palma, G., Arra, C., Maiolino, P., Adcock, I. M., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1738oc · Cited by 71 · see citing works
Zahm, C. D., Colluru, V. T., & McNeel, D. G. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0374 · Cited by 68 · see citing works
Self-citationYouinou, P., Mackenzie, L., Katsikis, P. D., Merdrignac, G., Isenberg, D. A., Tuaillon, N., Lamour, A., Goff, P. L., Jouquan, J., Drogou, A., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330306 · Cited by 68 · see citing works
The Immune Response Modifier Resiquimod Mimics CD40-Induced B Cell Activation
Bishop, G. A., Ramirez, L. M., Baccam, M., Busch, L. K., Pederson, L. K., & Tomai, M. A. (2001) · Cellular Immunology · doi:10.1006/cimm.2001.1769 · Cited by 68 · see citing works
Multiple Regulatory Mechanisms Control B-1 B Cell Activation
Sindhava, V. J., & Bondada, S. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00372 · Cited by 65 · see citing works
CD40-activated B cells induce anti-tumor immunityin vivo
Wennhold, K., Weber, T. M., Klein-González, N., Thelen, M., Garcia-Marquez, M. A., Chakupurakal, G., Fiedler, A., Schlößer, H., Fischer, R. N., Theurich, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7720 · Cited by 63 · see citing works
Ubiquitinylation of Igβ Dictates the Endocytic Fate of the B Cell Antigen Receptor
Zhang, M., Veselits, M., O’Neill, S. K., Hou, P., Reddi, A. L., Berlin, I., Ikeda, M., Nash, P., Longnecker, R., Band, H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4435 · Cited by 62 · see citing works
Wilkinson, S. T., Vanpatten, K. A., Fernandez, D. R., Brunhoeber, P., Garsha, K. E., Glinsmann‐Gibson, B., Grogan, T. M., Teruya‐Feldstein, J., & Rimsza, L. M. (2011) · Blood · doi:10.1182/blood-2011-07-363820 · Cited by 62 · see citing works
de Wit, J., Souwer, Y., Jorritsma, T., Bos, H. K., ten Brinke, A., Neefjes, J., & van Ham, S. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013016 · Cited by 62 · see citing works
Class I MHC presentation of exogenous antigens
Harding, C. V. (1996) · Journal of Clinical Immunology · doi:10.1007/bf01540955 · Cited by 61 · see citing works
TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens
Cervantes‐Barragán, L., Gil‐Cruz, C., Pastelin‐Palacios, R., Lang, K. S., Isibasi, A., Ludewig, B., & López-Macías, C. I. R. (2009) · European Journal of Immunology · doi:10.1002/eji.200838185 · Cited by 61 · see citing works
Shimabukuro‐Vornhagen, A., Draube, A., Liebig, T. M., Rothe, A., Kochanek, M., & von Bergwelt‐Baildon, M. S. (2012) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-31-47 · Cited by 60 · see citing works
Sagaert, X., & Wolf‐Peeters, C. D. (2003) · Immunology Letters · doi:10.1016/j.imlet.2003.09.007 · Cited by 60 · see citing works
Antigen phagocytosis by B cells is required for a potent humoral response
Riaño, A. M., Bovolenta, E. R., Mendoza, P., Oeste, C. L., Martín‐Bermejo, M. J., Bovolenta, P., Turner, M., Martínez, N., & Alarcón, B. (2018) · EMBO Reports · doi:10.15252/embr.201846016 · Cited by 60 · see citing works
Ollila, J., & Vihinen, M. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.09.007 · Cited by 59 · see citing works
Role of B-cell receptors for B-cell development and antigen-induced differentiation
Yam‐Puc, J. C., Zhang, L., Zhang, Y., & Toellner, K. (2018) · F1000Research · doi:10.12688/f1000research.13567.1 · Cited by 58 · see citing works
Cross, D., & Cambier, J. C. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.2.432 · Cited by 57 · see citing works
Effects of B cell–activating factor on tumor immunity
Yarchoan, M. M., Ho, W. J., Mohan, A. A., Shah, Y., Vithayathil, T., Leatherman, J. M., Dennison, L., Zaidi, N., Ganguly, S., Woolman, S., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.136417 · Cited by 56 · see citing works
Popi, A. F., Motta, F. L., Mortara, R. A., Schenkman, S., Lopes, J. D., & Mariano, M. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02883.x · Cited by 55 · see citing works
Moy, V. T., & Brian, A. A. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.1.1 · Cited by 55 · see citing works
Egwuagu, C. E., & Yu, C. (2015) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2015012558 · Cited by 54 · see citing works
PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy
Zahm, C. D., Moseman, J. E., Delmastro, L. E., & Mcneel, D. G. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1912892 · Cited by 54 · see citing works
Self-citationComparative In Vitro Immune Stimulation Analysis of Primary Human B Cells and B Cell Lines
Belle, K. V., Herman, J., Boon, L., Waer, M., Sprangers, B., & Louat, T. (2016) · Journal of Immunology Research · doi:10.1155/2016/5281823 · Cited by 50 · see citing works
Peritoneal cavity B‐1a cells promote peripheral CD4 + T‐cell activation
Margry, B., Wieland, W. H., van Kooten, P. J. S., van Eden, W., & Broere, F. (2013) · European Journal of Immunology · doi:10.1002/eji.201343418 · Cited by 50 · see citing works
Regulation of antigen-presentation-I. IFN-gamma induces antigen-presenting properties on B cells.
Hawrylowicz, C. M., & Unanue, E. R. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.12.4083 · Cited by 49 · see citing works
Mohib, K., Cherukuri, A., Zhou, Y. J., Ding, Q., Watkins, S. C., & Rothstein, D. M. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15546 · Cited by 48 · see citing works
Mathieu, M., Cotta‐Grand, N., Daudelin, J., Boulet, S., Lapointe, R., & Labrecque, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030139 · Cited by 47 · see citing works
TGFß, a Potent Regulator of Tumor Microenvironment and Host Immune Response, Implication for Therapy
Yang, H. H. (2010) · Current Molecular Medicine · doi:10.2174/156652410791317039 · Cited by 46 · see citing works
Chung, J. B., Wells, A. D., Adler, S. H., Jacob, A., Turka, L. A., & Monroe, J. G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.1758 · Cited by 46 · see citing works
Whipple, E. C., Shanahan, R. S., Ditto, A. H., Taylor, R. P., & Lindorfer, M. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2297 · Cited by 45 · see citing works
Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing
Watchmaker, P. B., Urban, J. A., Berk, E., Nakamura, Y., Mailliard, R. B., Watkins, S. C., van Ham, S. M., & Kaliński, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3857 · Cited by 44 · see citing works
Drake, J. R., Lewis, T. A., Condon, K., Mitchell, R. N., & Webster, P. C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.2.1150 · Cited by 44 · see citing works
Dynamics of MHC-I molecules in the antigen processing and presentation pathway
Truong, H. V., & Sgourakis, N. G. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.04.012 · Cited by 43 · see citing works
Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation
Silver, J. N., Zuo, T., Chaudhary, N., Kumari, R., Tong, P., Giguère, S., Granato, A., Donthula, R., Devereaux, C., & Wesemann, D. R. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171022 · Cited by 42 · see citing works
Popi, A. F., Osugui, L., Perez, K. R., Longo‐Maugéri, I. M., & Mariano, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034570 · Cited by 41 · see citing works
The Ins and Outs of Antigen Uptake in B cells
McShane, A. N., & Malinova, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.892169 · Cited by 41 · see citing works
Induction of Th17 cell differentiation by B-1 cells
Wang, Y., & Rothstein, T. L. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00281 · Cited by 40 · see citing works
Autologous and allogenic hybrid cell vaccine in patients with metastatic renal cell carcinoma
Kugler, Seseke, Thelen, Kallerhoff, MÜller, Stuhler, MÜller, & Ringert (1998) · British Journal of Urology · doi:10.1046/j.1464-410x.1998.00794.x · Cited by 40 · see citing works
Mussalem, J. S., Squaiella‐Baptistão, C. C., Teixeira, D., Yendo, T. M., Thies, F. G., Popi, A. F., Mariano, M., & Longo‐Maugéri, I. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033955 · Cited by 39 · see citing works
Sundstrom, J. B., & Ansari, A. A. (1995) · Transplant Immunology · doi:10.1016/0966-3274(95)80013-1 · Cited by 39 · see citing works
Role of B cell receptor signaling in IL‐10 production by normal and malignant B‐1 cells
Alhakeem, S. S., Sindhava, V. J., McKenna, M. K., Gachuki, B. W., Byrd, J. C., Muthusamy, N., & Bondada, S. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12802 · Cited by 39 · see citing works
Ritchie, D., Yang, J., Hermans, I. F., & Ronchese, F. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01517.x · Cited by 38 · see citing works
Differential Regulation of CCL22 Gene Expression in Murine Dendritic Cells and B Cells
Ghadially, H., Ross, X.-L., Kerst, C., Dong, J., Reske‐Kunz, A. B., & Ross, R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5620 · Cited by 37 · see citing works
Van den Bosch, G. A., Ponsaerts, P., Nijs, G., Lenjou, M., Vanham, G., Van Bockstaele, D. R., Berneman, Z. N., & Van Tendeloo, V. F. I. (2005) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2005.02733.x · Cited by 36 · see citing works
CD40L-Stimulated B Lymphocytes Are Polarized toward APC Functions after Exposure to IL-4 and IL-21
Possamaï, D., Pagé, G., Panès, R., Gagnon, É., & Lapointe, R. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001173 · Cited by 36 · see citing works
Tlaskalová-Hogenová, H., Mandel, L., Štëpánková, R., Bártová, J., Barot-Ciorbaru, R., Leclerc, M., Kovářů, F., & Trebichavský, I. (1992) · PubMed · Cited by 36 · see citing works
Flagged first, then by citations
3 of the 236 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [177]Hawrylowicz CM Unanue ER. Regulation of antigen-presentation-I. IFN-gamma induces antigen-presenting properties B cells J Immunol (1988) 141(12): 4083–8. 2974053
- [191]Jiang W Lederman MM Harding CV Rodriguez B Mohner RJ Sieg SF. TLR9 stimulation drives naive B cells to proliferate and to attain enhanced antigen presenting function. Eur J Immunol (2007) 37(8): 2205–13. doi: 10.1002/eji.200636984 17621369 · DOI
Cited by
Sorted by citations
Szukiewicz, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129818 · Cited by 208 · see citing works
Chimeric antigen receptor T cell therapy for autoimmune disease
Chung, J. B., Brudno, J. N., Borie, D. C., & Kochenderfer, J. N. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01035-3 · Cited by 151 · see citing works
The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited
Dzobo, K., Senthebane, D. A., & Dandara, C. (2023) · Cancers · doi:10.3390/cancers15020376 · Cited by 146 · see citing works
Recent advances in therapeutic cancer vaccines
Zaidi, N., Jaffee, E. M., & Yarchoan, M. M. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00820-z · Cited by 130 · see citing works
Zhang, Y., Xu, M., Ren, Y., Ba, Y., Liu, S., Zuo, A., Xu, H., Weng, S., Han, X., & Liu, Z. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01980-6 · Cited by 110 · see citing works
Tkachenko, A. S., Kupcová, K., & Havránek, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010010 · Cited by 84 · see citing works
A pan-cancer single-cell RNA-seq atlas of intratumoral B cells
Fitzsimons, E., Qian, D., Enica, A., Thakkar, K., Augustine, M., Gamble, S., Reading, J. L., & Litchfield, K. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.09.011 · Cited by 83 · see citing works
Identification of new immune target and signaling for cancer immunotherapy
Narote, S., Desai, S. A., Patel, V. P., Deshmukh, R., Raut, N., & Dapse, S. (2025) · Cancer Genetics · doi:10.1016/j.cancergen.2025.03.004 · Cited by 92 · see citing works
IgD−CD27− double negative (DN) B cells: Origins and functions in health and disease
Beckers, L., Somers, V. A., & Fraussen, J. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.03.003 · Cited by 80 · see citing works
Advancements in Vaccine Adjuvants: The Journey from Alum to Nano Formulations
Moni, S. S., Abdelwahab, S. İ., Jabeen, A., Elmobark, M. E., Aqaili, D. O., Gohal, G., Oraibi, B., Farasani, A., Jerah, A. A., Alnajai, M. M., et al. (2023) · Vaccines · doi:10.3390/vaccines11111704 · Cited by 81 · see citing works
Current and future advances in practice: IgG4-related disease
Wallace, Z. S., Katz, G., Hernandez-Barco, Y. G., & Baker, M. C. (2024) · Rheumatology Advances in Practice · doi:10.1093/rap/rkae020 · Cited by 74 · see citing works
Kumar, M., Yip, L., Wang, F., Marty, S., & Fathman, C. G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626082 · Cited by 71 · see citing works
de Molon, R. S., Vernal, R., Oliveira, G. E., Steffens, J. P., Ervolino, E., Theodoro, L. H., van den Beucken, J. J. J. P., & Tetradis, S. (2026) · Bone Research · doi:10.1038/s41413-025-00478-1 · Cited by 83 · see citing works
Dendritic Cells in Shaping Anti-Tumor T Cell Response
Mazzoccoli, L., & Liu, B. (2024) · Cancers · doi:10.3390/cancers16122211 · Cited by 68 · see citing works
Immunomodulatory Mechanisms of Chronic Wound Healing: Translational and Clinical Relevance
Riaz, M., Iqbal, M. Z., Klar, A. S., & Biedermann, T. (2025) · MedComm · doi:10.1002/mco2.70378 · Cited by 67 · see citing works
Mitochondria: the gatekeepers between metabolism and immunity
Trinchese, G., Cimmino, F., Catapano, A., Cavaliere, G., & Mollica, M. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1334006 · Cited by 51 · see citing works
Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers
Kotsifaki, A., Alevizopoulos, N., Dimopoulou, V., & Armakolas, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015332 · Cited by 46 · see citing works
T cell-based cancer immunotherapy: opportunities and challenges
Ma, K., Xu, Y., Cheng, H., Tang, K., Ma, J., & Huang, B. (2025) · 中国科学通报:英文版 · doi:10.1016/j.scib.2025.03.054 · Cited by 46 · see citing works
B cells and the coordination of immune checkpoint inhibitor response in patients with solid tumors
Flippot, R., Teixeira, M., Rey-Cárdenas, M., Carril-Ajuria, L., Rainho, L., Naoun, N., Jouniaux, J.-M., Boselli, L., Naigeon, M., Danlos, F., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008636 · Cited by 42 · see citing works
Dai, Y., Wu, J., Wang, J., Wang, H., Guo, B., Jiang, T., Cai, Z., Han, J., Zhang, H., Xu, B., et al. (2024) · Small · doi:10.1002/smll.202311344 · Cited by 42 · see citing works
Ceramide signaling in immunity: a molecular perspective
Thakkar, H., Vincent, V., & Chaurasia, B. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02642-2 · Cited by 41 · see citing works
Yang, H., Zhang, Z., Li, J., Wang, K., Zhu, W., & Zeng, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111825 · Cited by 38 · see citing works
Destabilisation of T cell-dependent humoral immunity in sepsis
Davies, K., & McLaren, J. E. (2024) · Clinical Science · doi:10.1042/cs20230517 · Cited by 34 · see citing works
Liu, D., Liu, L., Zhao, X., Zhang, X., Chen, X., Che, X., & Wu, G. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104702 · Cited by 35 · see citing works
Fang, D., Liu, Y., Dou, D., & Su, B. (2024) · Virologica Sinica · doi:10.1016/j.virs.2024.08.008 · Cited by 32 · see citing works
Embryonic macrophages support endocrine commitment during human pancreatic differentiation
Migliorini, A., Ge, S., Atkins, M. H., Oakie, A., Sambathkumar, R., Kent, G., Huang, H., Sing, A., Chua, C., Gehring, A. J., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.09.011 · Cited by 31 · see citing works
Barberis, M., & López, A. R. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1626 · Cited by 29 · see citing works
Human leukocyte antigen and tumor immunotherapy (Review)
Liu, D.-H., Mou, F.-F., An, M. J., & Xia, P. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5516 · Cited by 27 · see citing works
A Comprehensive Review of Hepatitis B Vaccine Nonresponse and Associated Risk Factors
Tahir, A., Shinkafi, S. A., Alshrari, A. S., Yunusa, A., Umar, M. T., Hudu, S. A., & Jimoh, A. O. (2024) · Vaccines · doi:10.3390/vaccines12070710 · Cited by 26 · see citing works
B cells: roles in physiology and pathology of pregnancy
Liu, J., Zeng, Q., Duan, Y., Yeung, W. S. B., Li, R., Ng, E. H. Y., Cheung, K. W., Zhang, Q., & Chiu, P. C. N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1456171 · Cited by 25 · see citing works
Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment
Shi, X., Cheng, X., Jiang, A., Shi, W., Zhu, L., Mou, W., Glaviano, A., Liu, Z., Cheng, Q., Lin, A., et al. (2024) · Advanced Science · doi:10.1002/advs.202403423 · Cited by 25 · see citing works
Challenges and considerations in multi-epitope vaccine design surrounding toll-like receptors
Shah, M., Rafiq, S., & Woo, H. G. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.10.013 · Cited by 25 · see citing works
Somasundaram, V., Ridnour, L. A., Cheng, R. Y. S., Walke, A. J., Kedei, N., Bhattacharyya, D. D., Wink, A. L., Edmondson, E. F., Butcher, D. O., Warner, A., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102529 · Cited by 25 · see citing works
Farahnak, K., Bai, Y. Z., Yokoyama, Y., Morkan, D. B., Liu, Z., Amrute, J., Falcon, A. D. F., Terada, Y., Liao, F., Li, W., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci170118 · Cited by 23 · see citing works
Therapeutic potential of CD20/CD3 bispecific antibodies in the treatment of autoimmune diseases
Huang, H., & Wei, X. (2024) · Rheumatology and Immunology Research · doi:10.1515/rir-2024-0029 · Cited by 23 · see citing works
Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets
Chen, X., Chen, F., Jia, S., Lu, Q., & Zhao, M. F. (2025) · Theranostics · doi:10.7150/thno.104900 · Cited by 23 · see citing works
Wang, Z., Zhao, Y., Wo, Y., Peng, Y., Hu, W., Wu, Z., Liu, P., Shang, Y., Liu, C., Chen, X., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216951 · Cited by 23 · see citing works
B cell development: transcriptional regulation and immunological mechanisms in homeostasis
Gómez-Manríquez, J., Hernández‐Bello, J., Muñóz-Valle, J. F., Sifuentes-Franco, S., Graciano‐Machuca, O., & Morales‐Núñez, J. J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1593338 · Cited by 22 · see citing works
Immunological mechanisms in Meniere’s disease
Yuan, V. G., Xia, A., & Maria, P. L. S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1639916 · Cited by 23 · see citing works
Vicente‐Gil, S., Nuñez-Ortiz, N., Morel, E., Serra, C. R., Docando, F., Díaz‐Rosales, P., & Tafalla, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1394501 · Cited by 22 · see citing works
Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation
Wang, Q., Yang, Y., Chen, Z., Li, B., Niu, Y., & Li, X. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050666 · Cited by 22 · see citing works
Immunosenescence and age-related immune cells: causes of age-related diseases
Kim, N., Sim, S.-J., Han, H.-G., Yoon, J.-H., & Han, Y. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01529-7 · Cited by 21 · see citing works
Neddylation Regulation of Immune Responses
Mao, H., Lin, X., & Sun, Y. (2023) · Research · doi:10.34133/research.0283 · Cited by 21 · see citing works
Himmelbauer, M. K., Bajrami, B., Basile, R., Capacci, A. G., Chen, T., Choi, C. K., Gilfillan, R., de Turiso, F. G.-L., Gu, C., Hoemberger, M., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00220 · Cited by 21 · see citing works
Adaptive immunity of materials: Implications for tissue healing and regeneration
Lee, J.-H., Shin, S.-J., Lee, J. H., Knowles, J. C., Lee, H.-H., & Kim, H.-W. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.07.027 · Cited by 21 · see citing works
Masnikosa, R., Cvetković, Z., & Pirić, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111384 · Cited by 21 · see citing works
Participation of B cell in immunotherapy of cancer
Chandnani, N., Gupta, I., Mandal, A., & Sarkar, K. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155169 · Cited by 20 · see citing works
B‐cell performance in chemotherapy: Unravelling the mystery of B‐cell therapeutic potential
Li, Z., Lin, A., Gao, Z., Jiang, A., Xiong, M., Song, J., Liu, Z., Cheng, Q., Zhang, J., & Luo, P. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1761 · Cited by 17 · see citing works
Tertiary lymphoid structures in ovarian cancer
Sun, G., & Liu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1465516 · Cited by 18 · see citing works
B cells drive CD4 T cell immunosenescence and age-associated health decline
Khan, S., Chakraborty, M., Wu, F., Chen, N., Wang, T., Chan, Y. T., Sayad, A., Vásquez, J. D. S., Kotlyar, M., Nguyen, K., et al. (2026) · Science Immunology · doi:10.1126/sciimmunol.adv7615 · Cited by 32 · see citing works
The multifaceted roles of B lymphocytes in metabolic dysfunction–associated steatotic liver disease
Li, H., & Xia, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1447391 · Cited by 20 · see citing works
B cells in non-lymphoid tissues
Samiea, A., Celis, G., Yadav, R., Rodda, L. B., & Moreau, J. M. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01137-6 · Cited by 18 · see citing works
Recent advances in regulatory immune cells: exploring the world beyond Tregs
Shi, P., Yu, Y., Xie, H., Yin, X., Chen, X., Zhao, Y., & Hai, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1530301 · Cited by 17 · see citing works
Ahmed, A., Li, S., Yu, J. J., & Shao, W.-H. (2025) · Pathophysiology · doi:10.3390/pathophysiology32040061 · Cited by 17 · see citing works
Piroozkhah, M., Gholinezhad, Y., Piroozkhah, M., Shams, E., & Mojarad, E. N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1298891 · Cited by 19 · see citing works
Atta, A., Salem, M. M., El-Said, K. S., & Mohamed, T. M. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00531-7 · Cited by 17 · see citing works
Ressler, J. M., Plaschka, M., Silmbrod, R., Bachmayr, V., Shaw, L. E., Silly, T., Zila, N., Stepan, A., Kusienicka, A., Tschandl, P., et al. (2025) · Nature Cancer · doi:10.1038/s43018-024-00879-x · Cited by 17 · see citing works
Lupus and recurrent pregnancy loss: the role of female sex hormones and B cells
Valeff, N. J., Ventimiglia, M. S., Diao, L., & Jensen, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1233883 · Cited by 15 · see citing works
Wu, Y., Jiang, H., Hu, Y., Dai, H., Zhao, Q., Zheng, Y., Liu, W., Rui, H., & Liu, B. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112769 · Cited by 15 · see citing works
The Role of NADPH Oxidase 2 in Leukocytes
Leiding, J. W., Mathews, C. E., Arnold, D. E., & Chen, J. (2025) · Antioxidants · doi:10.3390/antiox14030309 · Cited by 15 · see citing works
Intruders or protectors – the multifaceted role of B cells in CNS disorders
Aspden, J. W., Murphy, M., Kashlan, R., Xiong, Y.-Y., Poznansky, M., & Sîrbulescu, R. F. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1329823 · Cited by 15 · see citing works
Enhancing vaccine stability in transdermal microneedle platforms
Pahal, S., Huang, F., Singh, P., Sharma, N., Pham, H., Tran, T. B. T., Sakhrie, A., Akbaba, H., & Nguyen, T. D. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01854-4 · Cited by 13 · see citing works
Wen, R., Li, B., Wu, F., Mao, J., Azad, T., Wang, Y., Zhu, J., Zhou, X. Y., Xie, H., Qiu, X., et al. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103859 · Cited by 14 · see citing works
Zhao, Y., Song, S., Zhang, J., Ren, X., & Zhao, Y. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00923 · Cited by 16 · see citing works
Tieck, M. P., Vasilenko, N., Ruschil, C., & Kowarik, M. C. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1337339 · Cited by 13 · see citing works
Benhamouda, N., Besbes, A., Bauer, R., Mabrouk, N., Gadouas, G., Desaint, C., Chevrier, L., Lefebvre, M., Radenne, A., Roelens, M., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110441 · Cited by 13 · see citing works
Clinical and Immunologic Effects of Paraprobiotics in Long-COVID Patients
Docampo, M. J., Batruch, M., Oldrati, P., Berenjeno‐Correa, E., Hilty, M., Leventhal, G. E., Lutterotti, A., Martinꝉ, R., & Sospedra, M. (2024) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200296 · Cited by 13 · see citing works
New insights for the development of efficient DNA vaccines
Berger, S., Zeyn, Y., Wagner, E., & Bros, M. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.70053 · Cited by 13 · see citing works
B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer
Toney, N. J., Opdenaker, L. M., Frerichs, L., Modarai, S., Ma, A., Archinal, H., Ajayi, G. O., & Sims‐Mourtada, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-86064-1 · Cited by 13 · see citing works
Wang, H., Wu, X., Yuhan, S., Liu, A., He, Y., Xu, Z., Lü, Y., & Zhan, C. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.02.029 · Cited by 12 · see citing works
Hughes, D. L., Evans, A., Go, S., Eyres, M., Pan, L., Mukherjee, S., Soonawalla, Z. F., Willenbrock, F. W., & O’Neill, E. E. (2024) · Science Advances · doi:10.1126/sciadv.adm9071 · Cited by 12 · see citing works
Gut microbiota and immunity in health and diseases: a review
Okolie, M. C., Edo, G. I., Ainyanbhor, I. E., Jikah, A. N., Akpoghelie, P. O., Yousif, E. A., Zainulabdeen, K., Isoje, E. F., Igbuku, U. A., Orogu, J. O., et al. (2024) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-024-00355-1 · Cited by 12 · see citing works
Immunomodulatory functions of algal bioactive compounds
Jia, N., Zhang, S., Chen, R., He, X., Dai, C., El-Seedi, H. R., Chen, W., & Zhao, C. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2460634 · Cited by 12 · see citing works
Wang, R., Xiao, Z., Shi, X., Ye, F., Chen, J., Dong, M., Qiu, H., Zhang, Y., Shi, J., Zhou, M., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119789 · Cited by 12 · see citing works
Reprogramming the immune microenvironment in lung cancer
Chen, K., Luo, L., Li, Y., & Ge, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1684889 · Cited by 11 · see citing works
Uribe-Diaz, S., Santamaria, J. M., Hargis, B. M., Kwon, Y.-M., Vuong, C. N., & Erf, G. F. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105884 · Cited by 13 · see citing works
Tipping the Scale: Atheroprotective IgM-Producing B Cells in Atherosclerosis
Ransegnola, B. P., Pattarabanjird, T., & McNamara, C. A. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.319847 · Cited by 11 · see citing works
Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer
Xiao, X., Long, F., Yu, S., Wu, W., Nie, D., Ren, X., Li, W., Wang, X., Yu, L., Wang, P., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1496090 · Cited by 11 · see citing works
The dual role of chaperone-mediated autophagy in the response and resistance to cancer immunotherapy
Saberiyan, M., Gholami, S., Ejlalidiz, M., Manshadi, M. R., Noorabadi, P., & Hamblin, M. R. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104700 · Cited by 11 · see citing works
Gridley, J., Holland, B., Salinas, E., Trivedi, S., Dravid, P., Elrod, E. J., Jin, F., Kumari, A. R., Batista, M. N., Thapa, M., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000753 · Cited by 11 · see citing works
Ferroptosis and immunity: rewiring the tumor microenvironment for therapy
Ailun, G., Gu, H., Amadi, P. U., Chen, X., Abbas, M., Tuo, Y., & Zhang, D.-W. (2026) · RSC Advances · doi:10.1039/d5ra08026f · Cited by 10 · see citing works
Approaches for studying neuroimmune interactions in Alzheimer’s disease
Lin, C., Tian, Y., Tanzi, R. E., & Jorfi, M. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.10.002 · Cited by 10 · see citing works
The influence of the gut microbiota on B cells in autoimmune diseases
He, L., Li, X., Jiang, S., Ou, Y., Wang, S., Shi, N., Yang, Z., Yuan, J., Silverman, G. J., & Niu, H. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01195-5 · Cited by 10 · see citing works
Fahira, A., Amin, R. S., Arshad, U., Khan, M. I., Syed, A. A. S., Alshammari, A., Yang, Q., Wang, Z., Ali, L., & Shi, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17376 · Cited by 10 · see citing works
Alexander, S., Wang, W. X., Tseng, C., Douglas, T. R., & Chou, L. Y. T. (2024) · Small · doi:10.1002/smll.202400236 · Cited by 10 · see citing works
The molecular perspective on the melanoma and genome engineering of T-cells in targeting therapy
Hajibabaie, F., Abedpoor, N., Javanmard, S. H., Hasan, A., Sharifi, M., Rahimmanesh, I., Shariati, L., & Makvandi, P. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116980 · Cited by 10 · see citing works
T cell dysfunction in elderly ARDS patients based on miRNA and mRNA integration analysis
Mitsuyama, Y., Matsumoto, H., Togami, Y., Oda, S., Onishi, S., Yoshimura, J., Murtatsu, A., Ito, H., Ogura, H., Okuzaki, D., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1368446 · Cited by 9 · see citing works
Tumor Microenvironment: Obstacles and Opportunities for T Cell–Based Tumor Immunotherapies
Hu, M., Zhao, Y., Zhang, N., Gong, F., Zhang, W., Dong, C., Dai, J., & Wang, J. (2025) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-24-0747 · Cited by 9 · see citing works
Rheumatoid arthritis unmasked: the power of B cell depletion therapy
Alghazali, T. A. H., Saleh, R. O., Uthirapathy, S., Ballal, S., Abullais, S. S., Kalia, R., Arya, R., Sharma, R., Kumar, A., & Abdulamer, R. S. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10366-w · Cited by 9 · see citing works
α7nAChR on B cells directs T cell differentiation to prevent viral myocarditis
Lu, J., Chen, K., Cen, Z., Huang, Y., Li, Y., Chen, L., & Wu, W.-F. (2025) · JCI Insight · doi:10.1172/jci.insight.189323 · Cited by 9 · see citing works
Chronic rejection models for vascularized composite tissue allotransplantation
Fisher, D. T., Mackey, E. E., Kononov, E., Bogner, P. N., Sharma, U. C., Yu, H., Cetrulo, C. L., Seshadri, M., Kaliński, P., Skitzki, J. J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-01803-8 · Cited by 9 · see citing works
Razavi, F. T., Salari, N., Emami, A., Haghmorad, D., & Baharlou, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1567584 · Cited by 9 · see citing works
Tischer‐Zimmermann, S., Bonifacius, A., Santamorena, M. M., Mausberg, P., Stoll, S., Döring, M., Kalinke, U., Blasczyk, R., Maecker‐Kolhoff, B., & Eiz‐Vesper, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.878953 · Cited by 9 · see citing works
The show and tell of cross-presentation
Blander, J. M., Mon, K. J. Y., Jha, A., & Roycroft, D. (2023) · Advances in immunology · doi:10.1016/bs.ai.2023.08.002 · Cited by 9 · see citing works
Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study
Chen, Y., Jin, X., Wang, Q., Hu, S., & Huang, X. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04592-0 · Cited by 9 · see citing works
Zhang, Y. X., Lv, J., Bai, J. Y., Pu, X., & Dai, E. L. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2202264 · Cited by 9 · see citing works
Immunomodulatory Roles of IL-15 in Immune Cells and its Potential for Cancer Immunotherapy
Liu, Y., Ma, W., Tian, X., Wang, Q., Lü, X., Luo, Y., & Xu, J. (2024) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/0118715206321574240821112747 · Cited by 8 · see citing works
Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy
Song, S., Wang, C., Chen, Y., Zhou, X., Han, Y., & Zhang, H. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03936-7 · Cited by 8 · see citing works
Engineering B cells to treat and study human disease
Trivedi, N. H., Pitner, R. A., Rawlings, D. J., & James, R. G. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02757-y · Cited by 8 · see citing works
Obesity, bone marrow adiposity, and leukemia: Time to act
Kumar, V., & Stewart, J. H. (2023) · Obesity Reviews · doi:10.1111/obr.13674 · Cited by 8 · see citing works
- Authors
- Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- McNeel, Douglas G.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2022-09-08
- Volume
- 13
- Pages
- 954936-954936
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC9493130
- OpenAlex
- W4296111817
- Cited by
- 352
- References
- 236
- Citations by year
- 2026: 98 · 2025: 126 · 2024: 99 · 2023: 28 · 2022: 1
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01 CA219154, T32 CA009135, P30 CA014520)
- Congressionally Directed Medical Research Programs (W81XWH-17-1-0247)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B cells, antigen-presenting cells, antigen presentation, B cell receptor, T cell activation, CD4+ T cells, CD8+ T cells, tumor microenvironment, humoral immunity, cell-mediated immunity
- MeSH terms
- Antigen-Presenting Cells, B-Lymphocytes, Receptors, Antigen, B-Cell, Antigen Presentation, CD8-Positive T-Lymphocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review