Cited by 354T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Response and Inflammation

Role of B cells as antigen presenting cells

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Rastogi, Ichwaku, Jeon, Donghwan, Moseman, Jena E., Muralidhar, Anusha, Potluri, Hemanth K., McNeel, Douglas G.·2022·Frontiers in Immunology

Abstract

B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory response against pathogens, B cells are also capable of generating cell-mediated immunity. It has been demonstrated by several groups that B cells can activate antigen-specific CD4 and CD8 T cells, and can have regulatory and cytotoxic effects. The function of B cells as professional antigen presenting cells (APCs) to activate T cells has been largely understudied. This, however, requires attention as several recent reports have demonstrated the importance of B cells within the tumor microenvironment, and B cells are increasingly being evaluated as cellular therapies. Antigen presentation through B cells can be through antigen-specific (B cell receptor (BCR) dependent) or antigen non-specific (BCR independent) mechanisms and can be modulated by a variety of intrinsic and external factors. This review will discuss the pathways and mechanisms by which B cells present antigens, and how B cells differ from other professional APCs.

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Crossref · 10.3389/fimmu.2022.954936

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  • B cells produce cytokines and contribute to T cell activation through antigen presentation, which can shape overall immune responses.

    “In addition, B cells produce cytokines and contribute to T cell activation through antigen presentation which can shape the overall immune responses [41,42].”

    From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [42]

  • B cells are a crucial component of the adaptive immune system, responsible for producing antibodies and providing defense against infectious agents.

    “B cells are a crucial component of the adaptive immune system, responsible for producing antibodies, providing an important line of defense against infectious agents.”

    From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [42]

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  1. [177]Hawrylowicz CM Unanue ER. Regulation of antigen-presentation-I. IFN-gamma induces antigen-presenting properties B cells J Immunol (1988) 141(12): 4083–8. 2974053
  2. [191]Jiang W Lederman MM Harding CV Rodriguez B Mohner RJ Sieg SF. TLR9 stimulation drives naive B cells to proliferate and to attain enhanced antigen presenting function. Eur J Immunol (2007) 37(8): 2205–13. doi: 10.1002/eji.200636984 17621369 · DOI

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Authors
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
McNeel, Douglas G.
Venue
Frontiers in Immunology
Published
2022-09-08
Volume
13
Pages
954936-954936
ISSN
1664-3224 (ISSN-L)
OpenAlex
W4296111817
Cited by
352
References
236
Citations by year
2026: 98 · 2025: 126 · 2024: 99 · 2023: 28 · 2022: 1
FWCI
6.70
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (R01 CA219154, T32 CA009135, P30 CA014520)
  • Congressionally Directed Medical Research Programs (W81XWH-17-1-0247)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
B cells, antigen-presenting cells, antigen presentation, B cell receptor, T cell activation, CD4+ T cells, CD8+ T cells, tumor microenvironment, humoral immunity, cell-mediated immunity
MeSH terms
Antigen-Presenting Cells, B-Lymphocytes, Receptors, Antigen, B-Cell, Antigen Presentation, CD8-Positive T-Lymphocytes

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