The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.
GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING
Abstract
▪ Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-γ2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-γ2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future.
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Cited by
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Epstein-Barr virus: exploiting the immune system
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Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop
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Structure, function, and biology of SHIP proteins
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Metadata
- Authors
- Kurosaki, T.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1999-04
- Volume
- 17
- Issue
- 1
- Pages
- 555-592
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2153028178
- Cited by
- 432
- References
- 182
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kurosaki, T. (1999). GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.17.1.555
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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