The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Signaling and Transcription in T Helper Development
Abstract
The recognition of polarized T cell subsets defined by cytokine production was followed by a search to define the factors controlling this phenomenon. Suitable in vitro systems allowed the development of cytokine “recipes” that induced rapid polarization of naïve T cells into Th1 or Th2 populations. The next phase of work over the past several years has begun to define the intracellular processes set into motion during Th1/Th2 development, particularly by the strongly polarizing cytokines IL-12 and IL-4. Although somewhat incomplete, what has emerged is a richly detailed tapestry of signaling and transcription, controlling an important T cell developmental switch. In addition several new mediators of control have emerged, including IL-18, the intriguing Th2-selective T1/ST2 product, and heterogeneity in dendritic cells capable of directing cytokine-independent Th development.
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Cites
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Cited by
Boonstra, A., Barrat, F. J., Crain, C., Heath, V. L., Savelkoul, H. F. J., & O’Garra, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.4974 · Cited by 1,123
Molecular Mechanisms RegulatinG Th1 Immune Responses
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T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
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Molecular aspects of the pathogenesis of periodontitis
Meyle, J., & Chapple, I. (2015) · Periodontology 2000 · doi:10.1111/prd.12104 · Cited by 705
Immunological decision‐making: how does the immune system decide to mount a helper T‐cell response?
Kaiko, G. E., Horvat, J. C., Beagley, K. W., & Hansbro, P. M. (2008) · Immunology · doi:10.1111/j.1365-2567.2007.02719.x · Cited by 658
Metadata
- Authors
- Murphy, K. M., Ouyang, W., Farrar, J. D., Yang, J., Ranganath, S., Asnagli, H., Afkarian, M., & Murphy, T. L.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2000-04
- Volume
- 18
- Issue
- 1
- Pages
- 451-494
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2116562412
- Cited by
- 633
- References
- 15
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Murphy, K. M., Ouyang, W., Farrar, J. D., Yang, J., Ranganath, S., Asnagli, H., Afkarian, M., & Murphy, T. L. (2000). Signaling and Transcription in T Helper Development. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.18.1.451
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