The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
An Address System in the Vasculature of Normal Tissues and Tumors
Abstract
The vasculature of individual tissues is highly specialized. The endothelium in lymphoid tissues expresses tissue-specific receptors for lymphocyte homing, and recent work utilizing phage homing has revealed an unprecedented degree of specialization in the vasculature of other normal tissues. In vivo screening of libraries of phage that displace random peptide sequences on their surfaces has yielded specific homing peptides for a large number of normal tissues. The tissue-specific endothelial molecules to which the phage peptides home may serve as receptors for metastasizing malignant cells. Probing of tumor vasculature has yielded peptides that home to endothelial receptors expressed selectively in angiogenic neovasculature. These receptors, and those specific for the vasculature of individual normal tissues, are likely to be useful in targeting therapies to specific sites.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
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Self-citationLymphocyte Homing and Homeostasis
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Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
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Cited by
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221
Ligand-targeted therapeutics in anticancer therapy
Allen, T. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc903 · Cited by 1,647
Endothelial Cell Heterogeneity
Aird, W. C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006429 · Cited by 731
A history of prostate cancer treatment.
Denmeade, S. R., & Isaacs, J. T. (2002) · Nature reviews. Cancer · doi:10.1038/nrc801 · Cited by 591
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Metadata
- Authors
- Ruoslahti, E., & Rajotte, D.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2000-04
- Volume
- 18
- Issue
- 1
- Pages
- 813-827
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2113813607
- Cited by
- 239
- References
- 4
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ruoslahti, E., & Rajotte, D. (2000). An Address System in the Vasculature of Normal Tissues and Tumors. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.18.1.813
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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