The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Endothelial Cell Heterogeneity
Open accessAbstract
The endothelial lining of blood vessels shows remarkable heterogeneity in structure and function, in time and space, and in health and disease. An understanding of the molecular basis for phenotypic heterogeneity may provide important insights into vascular bed-specific therapies. First, we review the scope of endothelial heterogeneity and discuss its proximate and evolutionary mechanisms. Second, we apply these principles, together with their therapeutic implications, to a representative vascular bed in disease, namely, tumor endothelium.
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Cites
Tumor angiogenesis: therapeutic implications
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Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
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Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
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Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
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Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
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Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms
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Self-citationCancer as an evolutionary and ecological process
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Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Ricci-Vitiani, L., Pallini, R., Biffoni, M., Todaro, M., Invernici, G., Cenci, T., Maira, G., Parati, E. A., Stassi, G., Larocca, L. M., et al. (2010) · Nature · doi:10.1038/nature09557 · Cited by 1,379
Cited by
Microenvironmental regulation of tumour angiogenesis
De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847
Vascular heterogeneity and specialization in development and disease
Potente, M., & Mäkinen, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.36 · Cited by 653
Serum albumin in health and disease: esterase, antioxidant, transporting and signaling properties
Belinskaia, D. A., Voronina, P. A., Shmurak, V. I., Jenkins, R. O., & Goncharov, N. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910318 · Cited by 416
Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
Cho, C.-F., Wolfe, J. M., Fadzen, C. M., Calligaris, D., Hornburg, K., Chiocca, E. A., Agar, N. Y. R., Pentelute, B. L., & Lawler, S. E. (2017) · Nature Communications · doi:10.1038/ncomms15623 · Cited by 336
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
Dahlman, J. E., Kauffman, K. J., Xing, Y., Shaw, T. E., Mir, F. F., Dlott, C. C., Langer, R., Anderson, D. G., & Wang, E. T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620874114 · Cited by 335
Metadata
- Authors
- Aird, W. C.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-10-06
- Volume
- 2
- Issue
- 1
- Pages
- a006429-a006429
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W2118709967
- Cited by
- 731
- References
- 67
- Type
- posted content
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
