The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Molecular Mechanisms RegulatinG Th1 Immune Responses
Abstract
The T helper lymphocyte is responsible for orchestrating the appropriate immune response to a wide variety of pathogens. The recognition of the polarized T helper cell subsets Th1 and Th2 has led to an understanding of the role of these cells in coordinating a variety of immune responses, both in responses to pathogens and in autoimmune and allergic disease. Here, we discuss the mechanisms that control lineage commitment to the Th1 phenotype. What has recently emerged is a rich understanding of the cytokines, receptors, signal transduction pathways, and transcription factors involved in Th1 differentiation. Although the picture is still incomplete, the basic pathways leading to Th1 differentiation can now be understood in in vitro and a number of infection and disease models.
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Cites
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Cited by
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
Pagès, F., Berger, A., Camus, M., Sanchez-Cabo, F., Costes, A., Molidor, R., Mlecnik, B., Kirilovsky, A., Nilsson, M., Damotte, D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051424 · Cited by 2,135
Metadata
- Authors
- Szabo, S. J., Sullivan, B. M., Peng, S. L., & Glimcher, L. H.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2003-04
- Volume
- 21
- Issue
- 1
- Pages
- 713-758
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2130794319
- Cited by
- 1,019
- References
- 11
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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