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Cited by 1,146Inflammatory Bowel DiseaseT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

Powrie, Fiona, Leach, Michael W., Mauze, Smita, Menon, Satish, Barcomb Caddle, Linda, Coffman, Robert L.·1994·Immunity
DOI 10.1016/1074-7613(94)90045-0
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Abstract

We have described a murine model of IBD that was induced in C.B-17 scid mice by transfer of the CD45RBhi subpopulation of CD4+ T cells from normal BALB/c mice and could be prevented by cotransfer of the CD45RBlo CD4+ T cell subset. Here we have dissected the mechanism of pathogenesis of IBD in this model and used this information for rational immunotherapy of the disease. CD4+ cells from diseased mice displayed a highly polarized Th1 pattern of cytokine synthesis upon polyclonal stimulation in vitro. The administration of anti-IFN gamma MAb to mice soon after T cell transfer prevented development of colitis for up to 12 weeks. Continual neutralization of TNF with anti-TNF MAbs reduced the incidence of severe disease; however, neutralization of TNF during only the first 3-4 weeks had no effect. Severe colitis was completely abrogated in mice treated systemically with rIL-10, but not with rIL-4.

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Crossref · 10.1016/1074-7613(94)90045-0

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53 of 53 references verified0 citation errors · 0 not checkable

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  • Another therapeutic approach includes blocking Th1 responses or using neutralizing antibodies such as infliximab (anti-TNF) antibody.

    “Another therapeutic approach includes blocking Th1 responses or using neutralizing antibodies such as infliximab (anti-TNF) antibody.189,190”

    From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [189]

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Authors
Powrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L.
ORCID
Venue
Immunity
Publisher
Elsevier BV
Published
1994-10
Volume
1
Issue
7
Pages
553-562
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/1074-7613(94)90045-0
OpenAlex
W1971119469
Cited by
1,146
References
53
Citations by year
2026: 11 · 2025: 22 · 2024: 17 · 2023: 19 · 2022: 26 · 2021: 33 · 2020: 24 · 2019: 28 · 2018: 31 · 2017: 20 · 2016: 31 · 2015: 35 · 2014: 48 · 2013: 45 · 2012: 32
FWCI
15.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
inflammatory bowel disease, Th1 cells, SCID mice, colitis, anti-IFN-gamma monoclonal antibody, TNF-alpha neutralization, IL-10, IL-4, T cell transfer, immunotherapy, cytokine polarization
MeSH terms
Animals, Antibodies, Monoclonal, Colitis, Colon, Interferon-gamma, Interleukins, Mice, Inbred BALB C, RNA, Messenger, Time Factors, Tumor Necrosis Factor-alpha, Inflammatory Bowel Diseases, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Mice, SCID, Leukocyte Common Antigens, Th1 Cells, Models, Immunological, Mice

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