Positive and Negative Selection of T Cells

Apoptosis by Death Factor

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T cell receptor antagonist peptides induce positive selection.

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T cell tolerance by clonal elimination in the thymus

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

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bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

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Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

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Life-or-death decisions by the Bcl-2 protein family

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Origin of regulatory T cells with known specificity for antigen

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

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LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator

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Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

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Generic Signals and Specific Outcomes

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Evidence for a differential avidity model of T cell selection in the thymus

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Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

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The enemy within: keeping self-reactive T cells at bay in the periphery

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T-cell-receptor affinity and thymocyte positive selection

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Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

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Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

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Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

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Essential Role of LAT in T Cell Development

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A Thymic Precursor to the NK T Cell Lineage

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ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

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Intraepithelial lymphocytes: exploring the Third Way in immunology

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SELECTION OF THE T CELL REPERTOIRE

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Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

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Lymphostromal interactions in thymic development and function

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Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

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THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

Germain, R. N., & Štefanová, I. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.467 · Cited by 441

Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion.

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Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

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Autoreactivity by design: innate B and T lymphocytes

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

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Altered T cell development in mice with a targeted mutation of the CD3‐epsilon gene.

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Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

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Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation

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Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

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Selective requirement for MAP kinase activation in thymocyte differentiation

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Defective IL‐12 production in mitogen‐activated protein (MAP) kinase kinase 3 (Mkk3)‐deficient mice

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Effects of Cyclosporine A on T Cell Development and Clonal Deletion

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Exclusion and inclusion of α and β T cell receptor alleles

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

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Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

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JNK is required for effector T-cell function but not for T-cell activation

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The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

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RasGRP links T-cell receptor signaling to Ras

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EVOLUTION OF ANTIGEN BINDING RECEPTORS

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Contribution of Receptor Editing to the Antibody Repertoire

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Functional redundancy of the Nur77 and Nor‐1 orphan steroid receptors in T‐cell apoptosis

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A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

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The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis

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Role of self-peptides in positively selecting the T-cell repertoire

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TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT AND FUNCTION

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Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

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Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

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Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

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A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

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NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

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Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

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A defect in central tolerance in NOD mice

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Identification and Characterization of Thymic Epithelial Progenitor Cells

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The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells

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Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

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Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin β in Mesenteric Lymph Node Genesis

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Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

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The β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survival

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Positive and negative selection invoke distinct signaling pathways.

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Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

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Thymocyte Selection Is Regulated by the Helix-Loop-Helix Inhibitor Protein, Id3

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The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

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Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells

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CD3δ deficiency arrests development of the αβ but not the γδ T cell lineage

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Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

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Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains

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Developmentally Regulated Glycosylation of the CD8αβ Coreceptor Stalk Modulates Ligand Binding

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A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

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Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

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