Positive and Negative Selection of T Cells

Positive Selection of an H2-M3 Restricted T Cell Receptor

Berg, R. E., Princiotta, M. F., Irion, S., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80079-5 · Cited by 47

Limits to the differential avidity model of T cell selection in the thymus

Girão, C., Hu, Q., Sun, J. C.-Y., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.9.4205 · Cited by 46

Autonomous Maturation of α/β T Lineage Cells in the Absence of Cooh-Terminal Src Kinase (Csk)

Schmedt, C., & Tarakhovsky, A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.815 · Cited by 45

In vivo antagonism of a T cell response by an endogenously expressed ligand

Basu, D., Williams, C. B., & Allen, P. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14332 · Cited by 43

Deficiency of phospholipase C-γ1 impairs renal development and hematopoiesis

Shirane, M., Sawa, H., KOBAYASHI, Y., Nakano, T., Kitajima, K., Shinkai, Y., Nagashima, K., & Negishi, I. (2001) · Development · doi:10.1242/dev.128.24.5173 · Cited by 43

Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection

Haks, M. C., Pépin, E., van den Brakel, J. H. N., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020268 · Cited by 42

A Low Affinity TCR Ligand Restores Positive Selection of CD8+ T Cells In Vivo

Stefanski, H. E., Mayerova, D., Jameson, S. C., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6602 · Cited by 41

The Selection of M3-Restricted T Cells Is Dependent on M3 Expression and Presentation of N-Formylated Peptides in the Thymus

Chiu, N. M., Wang, B., Kerksiek, K. M., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1869 · Cited by 41

TCR-Associated ζ-FcϵRlγ heterodimers on CD4−CD8− NK1.1+ t cells selected by specific class I MHC antigen

Curnow, J., Boyer, C., Buferne, M., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90172-8 · Cited by 38

Inefficient ZAP-70 Phosphorylation and Decreased Thymic Selection In Vivo Result from Inhibition of NF-κB/Rel

Mora, A. L., Stanley, S. A., Armistead, W. J., Chan, A. C., & Boothby, M. R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5628 · Cited by 36

Identification and Characterization of Thymus LIM Protein: Targeted Disruption Reduces Thymus Cellularity

Kirchner, J., Forbush, K. A., & Bevan, M. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.24.8592-8604.2001 · Cited by 35

Inhibition of I‐Ad‐, but not Db‐restricted peptide‐induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

Xue, Y., Murdjeva, M., Okret, S., McConkey, D. J., Kiuossis, D., & Jondal, M. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260224 · Cited by 35

Activated p56 lck Directs Maturation of Both CD4 and CD8 Single-Positive Thymocytes

Sohn, S. J., Forbush, K. A., Pan, X. C., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2209 · Cited by 35

A Naturally Processed Mitochondrial Self-Peptide in Complex with Thymic Mhc Molecules Functions as a Selecting Ligand for a Viral-Specific T Cell Receptor

Sasada, T., Ghendler, Y., Neveu, J. M., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.883 · Cited by 34

Discrimination between maintenance‐ and differentiation‐inducing signals during initial and intermediate stages of positive selection

Anderson, G., Hare, K. J., Platt, N., & Jenkinson, E. J. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270803 · Cited by 33

Inhibition of thymocyte negative selection by T cell receptor antagonist peptides

Williams, O., Tanaka, Y., Bix, M., Murdjeva, M., Littman, D. R., & Kioussis, D. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260305 · Cited by 33

A T Cell Receptor–specific Blockade of Positive Selection

Baldwin, K. K., Reay, P. A., Wu, L. C., Farr, A. G., & Davis, M. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.13 · Cited by 32

Positive Selection of Cd4+ T Cells Is Induced in Vivo by Agonist and Inhibited by Antagonist Peptides

Kraj, P. J., Pacholczyk, R., Ignatowicz, H., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.407 · Cited by 31

The effect of HIV-1 regulatory proteins on cellular genes: derepression of the IL-2 promoter by Tat

Ehret, A., Li‐Weber, M., Frank, R. W., & Krammer, P. H. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200106)31:6 · Cited by 29

A Putative 12 Transmembrane Domain Cotransporter Expressed in Thymic Cortical Epithelial Cells

Kim, M. G., Flomerfelt, F. A., Lee, K.-N., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3185 · Cited by 27

Negative selection of thymocytes expressing the D10 TCR

Sant’Angelo, D. B., & Janeway, C. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102182499 · Cited by 27

Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions

Brabb, T., Huseby, E. S., Morgan, T. M., et al. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270121 · Cited by 24

Requirement of a second signal from antigen presenting cells in the clonal deletion of immature T cells

Alba, Y., Mazda, O., Davis, M. M., et al. (1994) · International Immunology · doi:10.1093/intimm/6.10.1475 · Cited by 22

Affinity of thymic self-peptides for the TCR determines the selection of CD8+ T lymphocytes in the thymus

Ober, B. T., Hu, Q., Opferman, J. T., et al. (2000) · International Immunology · doi:10.1093/intimm/12.9.1353 · Cited by 22

On the Self-Referential Nature of Naive MHC Class II-Restricted T Cells

Viret, C., He, X., & Janeway, C. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6183 · Cited by 21

Susceptibility and Resistance to Antigen-Induced Apoptosis in the Thymus of Transgenic Mice

Tarazona, R., Williams, O., Moskophidis, D., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5397 · Cited by 19

αβTCRs Differ in the Degree of Their Specificity for the Positively Selecting MHC/Peptide Ligand

Kraj, P. J., Pacholczyk, R., & Ignatowicz, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2251 · Cited by 19

Evaluating peptide repertoires within the context of thymocyte development

Barton, G. M., & Rudensky, A. Y. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0199 · Cited by 16

Positive Selection Is Limited by Available Peptide-Dependent MHC Conformations

Stefanski, H. E., Jameson, S. C., & Hogquist, K. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3519 · Cited by 15

Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide

Levelt, C. N., Mizoguchi, E., Huang, X., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14349 · Cited by 15

Cutting Edge: Positive Selection Induced by a Self-Peptide with TCR Antagonist Activity

Santori, F. R., Brown, S. M., Lu, Y., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6092 · Cited by 15

The lack of NF-κB transactivation and PKCε expression in CD4+CD8+ thymocytes correlates with negative selection

Simon, A. K., Auphan‐Anezin, N., Pophillat, M., Boyer, C., Ghosh, S., Rincón, M., Flavell, R. A., & Schmitt‐Verhulst, A. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400760 · Cited by 14

Specialisation of thymic epithelial cells for positive selection of CD4+8+ thymocytes.

Hare, K. J., Ej, J., & Anderson, G. (2001) · PubMed · Cited by 14

Surface Molecules Essential for Positive Selection Are Retained but Interfered in Thymic Epithelial Cells after Monolayer Culture

Sato, T., Sato, C., Suzuki, D., et al. (2001) · Cellular Immunology · doi:10.1006/cimm.2001.1823 · Cited by 13

An Incremental Increase in the Complexity of Peptides Bound to Class II MHC Changes the Diversity of Positively Selected αβ TCRs

Pacholczyk, R., Kraj, P. J., & Ignatowicz, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2357 · Cited by 11

A Physiological Ligand of Positive Selection Is Recognized as a Weak Agonist

Berg, R. E., Irion, S., Kattman, S., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4209 · Cited by 11

T cell receptor editing

McGargill, M. A., & Hogquist, K. A. (2000) · Immunology Letters · doi:10.1016/s0165-2478(00)00282-0 · Cited by 5

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes (vol 95, pg 8193, 1998)

Smyth, L. A., Williams, O., Huby, R. D. J., et al. (1998) · Proceedings of the National Academy of Sciences · Cited by 5

Untitled work

Hoerr, I. (2000) · doi:10.1002/1521-4141(200001)30:1

Untitled work

(1999) · doi:10.1002/(sici)1521-4141(199909)29:09

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866

CD4 + T Cells: Differentiation and Functions

Luckheeram, R. V., Zhou, R., Verma, A. D., & Xia, B. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/925135 · Cited by 1,381

Homeostasis of Naive and Memory T Cells

Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193

The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

Afzali, B., Lombardi, G., Lechler, R. I., & Lord, G. M. (2007) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2007.03356.x · Cited by 762

RANK/RANKL: Regulators of Immune Responses and Bone Physiology

Leibbrandt, A., & Penninger, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.016 · Cited by 420

Natural Selection

Saitou, N. (2013) · Computational biology · doi:10.1007/978-1-4471-5304-7_5 · Cited by 3

Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules

(1998) · doi:10.1002/(sici)1521-4141(199810)28:10

The thymus and negative selection

Sprent, J., & Kishimoto, H. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18512.x · Cited by 220

Role of thymic cortex-specific self-peptides in positive selection of T cells

Takahama, Y., Nitta, T., Ripen, A. M., Nitta, S., Murata, S., & Tanaka, K. (2010) · Seminars in Immunology · doi:10.1016/j.smim.2010.04.012 · Cited by 61

Quantitative constraints on the scope of negative selection

Müller, V., & Bonhoeffer, S. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00028-0 · Cited by 51