The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.
NETWORK COMMUNICATIONS: Lymphotoxins, LIGHT, and TNF
Abstract
▪ Abstract Lymphotoxins (LT) provide essential communication links between lymphocytes and the surrounding stromal and parenchymal cells and together with the two related cytokines, tumor necrosis factor (TNF) and LIGHT (LT-related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells), form an integrated signaling network necessary for efficient innate and adaptive immune responses. Recent studies have identified signaling pathways that regulate several genes, including chemokines and interferons, which participate in the development and function of microenvironments in lymphoid tissue and host defense. Disruption of the LT/TNF/LIGHT network alleviates inflammation in certain autoimmune disease models, but decreases resistance to selected pathogens. Pharmacological disruption of this network in human autoimmune diseases such as rheumatoid arthritis alleviates inflammation in a significant number of patients, but not in other diseases, a finding that challenges our molecular paradigms of autoimmunity and perhaps will reveal novel roles for this network in pathogenesis.
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Citations
Cites
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Activators and Target Genes of Rel/NF-кB Transcription Factors: From Bench to Bedside
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Cited by
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
NATURAL KILLER CELL DEVELOPMENTAL PATHWAYS: A Question of Balance
Di Santo, J. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090700 · Cited by 448
Dejardin, E. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.007 · Cited by 344
Migrating into the tumor: a roadmap for T cells
van der Woude, L. L., Gorris, M. A. J., Halilovic, A., Figdor, C. G., & de Vries, I. J. M. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.09.006 · Cited by 307
Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
Ruder, B., Atreya, R., & Becker, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081887 · Cited by 228
“TNFβ is expressed by T and B cells, Natural Killer cells and macrophages and plays fundamental roles for development and function of the immune system, for example, gut-associated lymphatic tissue [15,16], as well as during inflammation [17].”
Background
Metadata
- Authors
- Ware, C. F.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2005-04-01
- Volume
- 23
- Issue
- 1
- Pages
- 787-819
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2101583195
- Cited by
- 441
- References
- 162
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ware, C. F. (2005). NETWORK COMMUNICATIONS: Lymphotoxins, LIGHT, and TNF. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.23.021704.115719
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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