Cited by 101Viral-associated cancers and disordersCervical Cancer and HPV ResearchHepatitis B Virus Studies

Vaccines to Prevent Infections by Oncoviruses

Open access
Schiller, John T., Lowy, Douglas R.·2010·Annual Review of Microbiology

Abstract

It has been estimated that viruses are etiological agents in approximately 12% of human cancers. Most of these cancers can be attributed to infections by human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), Epstein-Barr virus (EBV), and Kaposi's sarcoma–associated herpesvirus (KSHV). Prophylactic vaccines against other pathogenic viruses have an excellent record as public health interventions in terms of safety, effectiveness, and ability to reach economically disadvantaged populations. These considerations should prompt efforts to develop and implement vaccines against oncoviruses. Safe and effective HBV and HPV vaccines, based on virus-like particles, are commercially available, and the major focus is now on vaccine delivery, especially to low-resource settings. HCV and EBV vaccines are under active development, but few clinical trials have been conducted, and none of the candidate vaccines has proven to be sufficiently effective to warrant commercialization. Efforts to develop KSHV vaccines have been more limited.

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Crossref · 10.1146/annurev.micro.112408.134019

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85 of 85 references verified0 citation errors · 0 not checkable

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  • Cancer-prevention vaccines against human papillomavirus and HBV have greatly reduced the incidence of certain virally driven cancers, including HBV-related HCC.

    “Cancer-prevention vaccines, such as those for human papillomavirus and HBV, have greatly reduced the incidence or certain virally driven cancers, including HBV-related HCC130.”

    From Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma (2024) · cites this paper as [130]

    The Hepatitis B Virus section documents a reduction in childhood HCC incidence in Taiwan following universal HBV vaccination. It also says HBV was the only oncovirus vaccine shown to prevent human cancer; the cited paper does not establish that HPV vaccination had already reduced cancer incidence. (LLM, conf=0.90)

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Cites

1 retracted

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Research works printed but not linked: 1

  1. [48]Knipe DM Howley PM 2007 Field’s Virology Philadelphia Lippincott Williams & Wilkins

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Authors
Schiller, J. T., & Lowy, D. R.
Affiliations
National Cancer Institute (US)
Venue
Annual Review of Microbiology
Published
2010-10-13
Volume
64
Issue
1
Pages
23-41
ISSN
  • 0066-4227 (ISSN-L)
  • 1545-3251
OpenAlex
W2118603752
Cited by
101
References
85
Citations by year
2026: 6 · 2025: 6 · 2024: 11 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 2 · 2014: 4 · 2013: 9 · 2012: 15
FWCI
1.29
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (ZIABC010579)
Topics
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Keywords
viral etiology of cancer, human papillomavirus, hepatitis B virus, hepatitis C virus, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, virus-like particle vaccine, vaccine delivery, resource-limited settings, vaccine safety and effectiveness
MeSH terms
Herpesvirus 4, Human, Hepatitis B, Hepatitis B virus, Hepatitis C, Herpesviridae Infections, Humans, Neoplasms, Retroviridae, Viral Vaccines, Hepacivirus, Herpesvirus 8, Human, Epstein-Barr Virus Infections, Papillomaviridae, Papillomavirus Infections

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