The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Protein Tyrosine Phosphatases in Autoimmunity
Abstract
Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant of the lymphoid tyrosine phosphatase (PTPN22), which is associated with multiple autoimmune diseases, and mutations that affect the exon-intron splicing of CD45 (PTPRC). We also find it likely that additional PTPs are involved in susceptibility to autoimmune and inflammatory diseases. Finally, we discuss the possibility that PTPs regulating the immune system may serve as therapeutic targets.
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Cites
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
Ueda, H., Howson, J. M. M., Esposito, L., Heward, J., Snook, Chamberlain, G., Rainbow, D. B., Hunter, K. M. D., Smith, A. N., Di Genova, G., et al. (2003) · Nature · doi:10.1038/nature01621 · Cited by 2,175
Protein Tyrosine Phosphatases in the Human Genome
Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., & Mustelin, T. (2004) · Cell · doi:10.1016/j.cell.2004.05.018 · Cited by 1,886
Self-citationDifferential regulation of MAP kinase signalling by dual-specificity protein phosphatases
Owens, D. M., & Keyse, S. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210412 · Cited by 777
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724
Concannon (2005) · doi:10.2337/diabetes.54.10.2995 · Cited by 257
Cited by
Detecting shared pathogenesis from the shared genetics of immune-related diseases
Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551
Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease
Jansson, J., Willing, B., Lucio, M., Fekete, A., Dicksved, J., Halfvarson, J., Tysk, C., & Schmitt-Kopplin, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006386 · Cited by 512
Recent Advances in the Genetics of Autoimmune Disease
Gregersen, P. K., & Olsson, L. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132653 · Cited by 339
CD45 in human physiology and clinical medicine
Rheinländer, A., Schraven, B., & Bommhardt, U. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.01.009 · Cited by 294
Metadata
- Authors
- Vang, T., Miletic, A. V., Arimura, Y., Tautz, L., Rickert, R. C., & Mustelin, T.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2008-04-01
- Volume
- 26
- Issue
- 1
- Pages
- 29-55
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2160241168
- Cited by
- 178
- References
- 6
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vang, T., Miletic, A. V., Arimura, Y., Tautz, L., Rickert, R. C., & Mustelin, T. (2008). Protein Tyrosine Phosphatases in Autoimmunity. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.26.021607.090418
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
