The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Factors Affecting B-Cell Growth and Differentiation
Abstract
Since the discovery of T-B interactions in the antibody response, the mechanism of the regulatory functions of T cells in the B-cell response has been studied extensively in immunology. The possibility that helper functions of T cells may be mediated by soluble products released from T cells was originally proposed by Dutton and his colleagues in 1971 (1). In their experiment with murine splenic B cells, they showed that anti-SRBC (sheep red blood cell) response in T cell-depleted splenic lymphocytes could be reconstituted by culture supernatants of mixed lymphocyte reactions. This was confirmed by Schimpl & Wecker (2) and several other investi gators (3-5) who showed the active soluble factor(s) in culture supernatants of mitogens or antigen-stimulated T cells. Schimpl & Wecker demonstrated that cell-free supernatants from alloantigen-stimulated or concanavalin A (Con A}-stimulated T cells could fully substitute for T cells in the response in vitro to unrelated antigens such as SRBC. They postulated that T cells stimulated by their specific antigen released a substance, T cell-replacing factor (TRF), which was able to stimulate B cells to proliferate and/or differentiate only when B cells carried antigens on their receptors. Essentially the same result was reported by Kishimoto & Ishizaka with rabbit B cells (3). They demonstrated that anti-DNP (dinitrophenyl) antibody response could be induced in DNP-primed B cells by the stimulation with DNP-heterologous carrier conjugate and a cell-free supernatant from carrier-primed T cells stimulated with the primed carrier antigen. In a series of experiments, they also demonstrated that the factor(s)
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Citations
Cites
Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows
Morgan, D. A., Ruscetti, F. W., & Gallo, R. (1976) · Science · doi:10.1126/science.181845 · Cited by 2,493
Long term culture of tumour-specific cytotoxic T cells
GILLIS, S., & SMITH, K. A. (1977) · Nature · doi:10.1038/268154a0 · Cited by 1,386
Structure and expression of a cloned cDNA for human interleukin-2
Taniguchi, T., Matsui, H., Fujita, T., Takaoka, C., Kashima, N., Yoshimoto, R., & Hamuro, J. (1983) · Nature · doi:10.1038/302305a0 · Cited by 1,182
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.
Howard, M., Farrar, J., Hilfiker, M., Johnson, B., Takatsu, K., Hamaoka, T., & Paul, W. E. (1982) · The Journal of experimental medicine · doi:10.1084/jem.155.3.914 · Cited by 1,099
Replacement of T-Cell Function by a T-Cell Product
SCHIMPL, A., & WECKER, E. (1972) · Nature New Biology · doi:10.1038/newbio237015a0 · Cited by 529
DUTTON, R. W., FALKOFF, R., HIRST, J. A., HOFFMANN, M., KAPPLER, J. W., KETTMAN, J. R., LESLEY, J. F., & VANN, D. (1971) · Progress in Immunology · doi:10.1016/b978-0-12-057550-3.50033-8 · Cited by 275
γ-Interferon is one of several direct B cell-maturing lymphokines
Sidman, C. L., Marshall, J. D., Shultz, L. D., Gray, P. W., & Johnson, H. M. (1984) · Nature · doi:10.1038/309801a0 · Cited by 232
Swain, S. L., Howard, M., Kappler, J. W., Marrack, P., Watson, J., Booth, R., Wetzel, G. D., & Dutton, R. W. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.158.3.822 · Cited by 199
Role of γ-interferon in antibody-producing responses
Leibson, H. J., Gefter, M. L., Zlotnik, A., Marrack, P., & Kappler, J. W. (1984) · Nature · doi:10.1038/309799a0 · Cited by 196
B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor.
Leibson, H. J., Marrack, P., & Kappler, J. W. (1981) · The Journal of Experimental Medicine · doi:10.1084/jem.154.5.1681 · Cited by 156
Cited by
IL‐6 in inflammation, immunity, and disease
Tanaka, T., Narazaki, M., & Kishimoto, T. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016295 · Cited by 5,046
Self-citationHirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139
Self-citationIL-6: From its discovery to clinical applications
Kishimoto, T. (2010) · International Immunology · doi:10.1093/intimm/dxq030 · Cited by 846
Self-citationInterleukin-6 and its receptor: a paradigm for cytokines
Kishimoto, T., Akira, S., & Taga, T. (1992) · Science · doi:10.1126/science.1411569 · Cited by 665
Self-citationNaitoh, Y., Fukata, J., Tominaga, T., Nakai, Y., Tamai, S., Mori, K., & Imura, H. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81305-6 · Cited by 421
Metadata
- Authors
- Kishimoto, T.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1985-04
- Volume
- 3
- Issue
- 1
- Pages
- 133-157
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2175632479
- Cited by
- 359
- References
- 27
- FWCI
- 21.13
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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