The DOI matches its Crossref record.
Memory B and T Cells
Abstract
Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs upregulation of adhesion molecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These memory cells mediate a speedy and more effective immune response upon reencounter of the antigen (13,1258).”
From About Sleep's Role in Memory (2013) · cites this paper as [1258]
Citations
Cited by
Sorted by citations
Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
Asano, M., Toda, M., Sakaguchi, N., & Sakaguchi, S. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.387 · Cited by 1,328
Itoh, M., Takahashi, T., Sakaguchi, N., Kuniyasu, Y., Shimizu, J., Otsuka, F., & Sakaguchi, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5317 · Cited by 1,209
Metadata
- Authors
- Vitetta, E. S., Berton, M. T., Burger, C., Kepron, M., Lee, W. T., & Yin, X. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1991-04
- Volume
- 9
- Issue
- 1
- Pages
- 193-217
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2025036070
- Cited by
- 187
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai021229-05, 5f32ai007959-02, 2p01ai011851-16)
- National Institute of Allergy and Infectious Diseases (AI-07959, AI-21229, AI11851)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- memory B cells, memory T cells, immunological memory, secondary antibody response, B cell receptor, T cell receptor, affinity maturation, lymphokines, adhesion molecules, T cell activation, B cell activation
- MeSH terms
- Animals, Antibody Affinity, Antigens, Differentiation, B-Lymphocytes, Cell Survival, Humans, Immunologic Memory, T-Lymphocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
