Cited by 190T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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Memory B and T Cells

Vitetta, E S, Berton, M T, Burger, C, Kepron, M, Lee, W T, Yin, X M·1991·Annual Review of Immunology

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Abstract

Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs upregulation of adhesion molecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response.

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Crossref · 10.1146/annurev.iy.09.040191.001205

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
Asano, M., Toda, M., Sakaguchi, N., & Sakaguchi, S. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.387 · Cited by 1,328
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Itoh, M., Takahashi, T., Sakaguchi, N., Kuniyasu, Y., Shimizu, J., Otsuka, F., & Sakaguchi, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5317 · Cited by 1,209
ON IMMUNOLOGICAL MEMORY
Zinkernagel, R. M., Bachmann, M. F., Kündig, T. M., Oehen, S., Pirchet, H., & Hengartner, H. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.333 · Cited by 474
The extent of affinity maturation differs between the memory and antibody‐forming cell compartments in the primary immune response
Smith, K. G. C., Light, A., Nossal, G. J. V., & Tarlinton, D. M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.2996 · Cited by 447
“…affinity have supported the notion that the memory population is uniformly high affinity since the AFCs (Blier and Bothwell, 1987) and this number may be substantially less than the number of clones in the memoryarising after secondary stimulation are all high affinity (e.g. Vitetta et al., 1991).”
Background
Antigen-Specific Development of Primary and Memory T Cells in Vivo
McHeyzer‐Williams, M. G., & Davis, M. M. (1995) · Science · doi:10.1126/science.7535476 · Cited by 439
Lymphocyte life-span and memory
Sprent, J., & Tough, D. F. (1994) · Science · doi:10.1126/science.8073282 · Cited by 398
Germinal center development
Liu, Y., & Arpin, C. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00963.x · Cited by 362
Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2
Liu, Y.-J., Barthélémy, C., de BOUTEILLER, O., Arpin, C., Durand, I., & Banchereau, J. (1995) · Immunity · doi:10.1016/1074-7613(95)90048-9 · Cited by 347
Long-lasting memory T cell responses following self-limited acute hepatitis B.
Penna, A., Artini, M., Cavalli, A., Levrero, M., Bertoletti, A., Pilli, M., Chisari, F. V., Rehermann, B., Prete, G. D., Fiaccadori, F., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118902 · Cited by 292
Targeting B cells and plasma cells in autoimmune diseases
Hofmann, K., Clauder, A.-K., & Manz, R. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00835 · Cited by 294
Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation
Kuniyasu, Y., Takahashi, T., Itoh, M., Shimizu, J., Toda, G., & Sakaguchi, S. (2000) · International Immunology · doi:10.1093/intimm/12.8.1145 · Cited by 289
The pharmacological basis of anti-IgE therapy
Chang, T. W. (2000) · Nature Biotechnology · doi:10.1038/72601 · Cited by 290
“Furthermore, memory B cells for making IgE response, which bear mIg”
Background
Immunopathogenesis and treatment of the guillain‐barré syndrome—part I
Hartung, H., Toyka, K. V., Pollard, J. D., et al. (1995) · Muscle & Nerve · doi:10.1002/mus.880180202 · Cited by 289
T and B memory cells
Sprent, J. (1994) · Cell · doi:10.1016/0092-8674(94)90338-7 · Cited by 278
Telomere lengthening and telomerase activation during human B cell differentiation
Weng, N., Granger, L., & Hodes, R. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10827 · Cited by 272
Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells
Förster, R., Emrich, T., Kremmer, E., & Lipp, M. (1994) · Blood · doi:10.1182/blood.v84.3.830.830 · Cited by 275
Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection
Lieberman, J., Shankar, P., Manjunath, N., & Andersson, J. (2001) · Blood · doi:10.1182/blood.v98.6.1667 · Cited by 226
Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
Weng, N., Palmer, L. D., Levine, B. L., Lane, H. C., June, C. H., & Hodes, R. J. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01026.x · Cited by 201
Altered Antigen Presentation in Mice Lacking H2-O
Liljedahl, M., Winqvist, O., Surh, C. D., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80475-6 · Cited by 177
Activation of naive and memory T cells by interleukin-15
Kanegane, H., & Tosato, G. (1996) · Blood · doi:10.1182/blood.v88.1.230.bloodjournal881230 · Cited by 176
The Development of Functionally Responsive T Cells
Rothenberg, E. V. (1992) · Advances in immunology · doi:10.1016/s0065-2776(08)60487-3 · Cited by 160
Secondary memory CD8+ T cells are more protective but slower to acquire a central–memory phenotype
Jabbari, A., & Harty, J. T. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052237 · Cited by 168
Memory B Cells Are Biased Towards Terminal Differentiation: A Strategy That May Prevent Repertoire Freezing
Arpin, C., Banchereau, J., & Liu, Y.-J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.6.931 · Cited by 163
CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection
Chen, G., Shankar, P., Lange, C. G., Valdez, H., Skolnik, P. R., Wu, L., Manjunath, N., & Lieberman, J. (2001) · Blood · doi:10.1182/blood.v98.1.156 · Cited by 159
Normal Human IgD+IgM− Germinal Center B Cells Can Express Up to 80 Mutations in the Variable Region of Their IgD Transcripts
Liu, Y.-J., de BOUTEILLER, O., Arpin, C., et al. (1996) · Immunity · doi:10.1016/s1074-7613(00)80486-0 · Cited by 153
Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.
Zhou, T., Edwards, C. K., & Mountz, J. D. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.1.129 · Cited by 150
“Immune system aging is associated with an increase in percentage of memory T cells characterized by expression of CD44 and CD45RO (11-13, 47-50 ).”
BackgroundMethod
Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion.
McNeill, H., Ryan, T. A., Smith, S. J., & Nelson, W. J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.5.1217 · Cited by 151
“…neurons to target tissues (Hortsch and Goodman, 1991; Jessell, 1988), activation or silencing of cells in the immune system (Kosco and Gray, 1992; Vitetta et al., 1991) and determination of cell fate and function in epithelial cells 0~leming and Johnson, 1988; Rodriguez-Boulan and Nelson, 1989),…”
Background
Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency
Razvi, E. S., & Welsh, R. M. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.5754-5765.1993 · Cited by 145
The teleost humoral immune response
Ye, J., Kaattari, I. M., Ma, C., & Kaattari, S. L. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.10.015 · Cited by 142
Locus-specific somatic hypermutation in germinal centre T cells
Zheng, B. Q., Xue, W., & Kelsoe, G. H. (1994) · Nature · doi:10.1038/372556a0 · Cited by 134
Innate and adaptive immune responses in Parkinson's disease
Schonhoff, A. M., Williams, G. P., Wallen, Z. D., Standaert, D. G., & Harms, A. S. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.10.006 · Cited by 119
The Magnitude of the Antibody and Memory B Cell Responses during Priming with a Protein-Polysaccharide Conjugate Vaccine in Human Infants Is Associated with the Persistence of Antibody and the Intensity of Booster Response
Rohner, G. B., Snape, M. D., Kelly, D. F., John, T. M., Morant, A., Yu, L., Borkowski, A., Ceddia, F., Borrow, R., Siegrist, C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2165 · Cited by 114
“Therefore, it is possible that the MenC-memory B cells appearing rapidly in the peripheral blood after immunization are recirculating memory B cells, which at steady state reside in peripheral lymphoid organs (mostly in mucosal surfaces) (15, 45), or possibly in the bone marrow (18) and are activated to re-circulate b…”
Background
Expression and kinetics of cytokines determined by intracellular staining using flow cytometry
Winkler, B., Schlenke, P., & Seyfarth, M. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00200-2 · Cited by 106
A transgenic mouse model to analyze CD8 + effector T cell differentiation in vivo
Manjunath, N., Shankar, P., Stockton, B. M., Dubey, P., Lieberman, J., & von Andrian, U. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13932 · Cited by 100
Activation and differentiation requirements of primary T cells in vitro.
Sagerström, C. G., Kerr, E. M., Allison, J. P., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8987 · Cited by 99
Memory-like natural killer cells for cancer immunotherapy
Gang, M., Wong, P., Berrien-Elliott, M. M., & Fehniger, T. A. (2020) · Seminars in Hematology · doi:10.1053/j.seminhematol.2020.11.003 · Cited by 100
Human Cytokine-Induced Memory-Like Natural Killer Cells
Berrien-Elliott, M. M., Wagner, J. A., & Fehniger, T. A. (2015) · Journal of Innate Immunity · doi:10.1159/000382019 · Cited by 105
P-selectin (CD62) binds to subpopulations of human memory T lymphocytes and natural killer cells
Moore, K. L., & Thompson, L. F. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80790-9 · Cited by 97
Is there any kind of adaptive immunity in invertebrates?
Arala-Chaves, M. P., & Sequeira, T. (2000) · Aquaculture · doi:10.1016/s0044-8486(00)00430-0 · Cited by 95
“…the presence of these molecules in the memory immunocompetent cells, these cells have the capacity to be activated faster and Žrespond to smaller amounts of antigens than naive cells Swain et al., 1991; Vitetta et al., 1991; Gray, 1993; Mackay, 1993; Kearney et al., 1994; Sprent, 1994; Sprent and .”
Background
Effect of Food Restriction on Life Span and Immune Functions in Long-Lived Fischer-344 × Brown Norway F1 Rats
Fernandes, G., Venkatraman, J. T., Turturro, A., Attwood, V. G., & Hart, R. W. (1997) · Journal of Clinical Immunology · doi:10.1023/a:1027344730553 · Cited by 91
Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene.
Lindemann, D., Wilhelm, R., Renard, P., et al. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.3.797 · Cited by 86
“In the mouse system, naive T cells can be distinguished from memory or antigen-triggered T cells by differential expression of the cell surface markers Pgp-1 (CD44) and Mel-14 (LECAM-1) ( 29 ).”
Background
CD40 Stimulation of Human Peripheral B Lymphocytes: Distinct Response from Naive and Memory Cells
Fecteau, J. F., & Néron, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4621 · Cited by 86
Continued Antigen Stimulation Is Not Required During CD4+ T Cell Clonal Expansion
Lee, W. T., Pasos, G., Cecchini, L. F., & Mittler, J. N. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1682 · Cited by 85
Self-citation
Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.
Teitelbaum, I., & McGuinness, S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118044 · Cited by 80
High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire
van Es, J. H., Gmelig-Meyling, F. H. J., & Logtenberg, T. (1992) · European Journal of Immunology · doi:10.1002/eji.1830221046 · Cited by 80
Life span of naive and memory t cells
Tough, D. F., & Sprent, J. (1995) · Stem Cells · doi:10.1002/stem.5530130305 · Cited by 78
Antibody-forming cell response to virus challenge in mice immunized with DNA encoding the influenza virus hemagglutinin
Justewicz, D. M., Morin, M. J., Robinson, H. L., et al. (1995) · Journal of Virology · doi:10.1128/jvi.69.12.7712-7717.1995 · Cited by 78
IMPERFECT VACCINES AND THE EVOLUTION OF PATHOGENS CAUSING ACUTE INFECTIONS IN VERTEBRATES
Ganusov, V. V., & Antia, R. (2006) · Evolution · doi:10.1111/j.0014-3820.2006.tb01174.x · Cited by 77
Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets
Schindowski, K., Fröhlich, L. O., Maurer, K., Müller, W. E., & Eckert, A. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00396-7 · Cited by 75
“…revealed an increase of reactive oxygen species (ROS) in aged subjects (Schindowski et al., 2000) or elevated by-products caused by ROS (e.g. lipidperoxidation (Hendricks and Heidrick, 1998), oxidized proteins (Stadtman, 1992; Berlett and Stadtman, 1997) and DNA-damage (Wei et al., 1998)).”
Background
Viruses and T Cell Turnover: Evidence for Bystander Proliferation
Tough, D. F., & Sprent, J. (1996) · Immunological Reviews · doi:10.1111/j.1600-065x.1996.tb00699.x · Cited by 76
Mechanisms of T cell organotropism
Fu, H., Ward, E. J., & Marelli‐Berg, F. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2211-4 · Cited by 76
A Critical Control Element for Interleukin-4 Memory Expression in T Helper Lymphocytes
Tykocinski, L., Hájková, P., Chang, H., Stamm, T., Sözeri, O., Löhning, M., Hu‐Li, J., Niesner, U., Kreher, S., Friedrich, B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502038200 · Cited by 70
Differential TCR signaling and the generation of memory T cells.
Färber, D. L. (1998) · PubMed · Cited by 69
Heterogeneity in cytokine profiles of Babesia bovis-specific bovine CD4+ T cells clones activated in vitro
Brown, W. C., Woods, V. M., Dobbelaere, D. A. E., et al. (1993) · Infection and Immunity · doi:10.1128/iai.61.8.3273-3281.1993 · Cited by 67
Human Autoreactive CD4+ T Cells from Naive CD45RA+ and Memory CD45RO+ Subsets Differ with Respect to Epitope Specificity and Functional Antigen Avidity
Muraro, P. A., Pette, M., Bielekova, B., McFarland, H. F., & Martinꝉ, R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.5474 · Cited by 62
Vesicular stomatitis virus Indiana glycoprotein as a T-cell-dependent and -independent antigen
Freer, G., Burkhart, C., Ciernik, I. F., et al. (1994) · Journal of Virology · doi:10.1128/jvi.68.6.3650-3655.1994 · Cited by 62
Cutting Edge Commentary: Differential TCR Signaling and the Generation of Memory T Cells
Färber, D. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.2.535 · Cited by 68
“The idea that low affinity ligands favor generation of memory T cells appears in sharp contrast to evidence that persisting memory responses have a greater affinity for their antigenic ligand ( 45 ).”
Background
A single autosomal gene defect severely limits IgG but not IgM responses in B lymphocyte‐deficient A/WySnJ mice
Miller, D. J., Hanson, K. D., Carman, J., et al. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220213 · Cited by 59
Innate immune memory in inflammatory arthritis
Jeljeli, M. M., & Adamopoulos, I. E. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01009-0 · Cited by 60
CD3 antigen‐mediated calcium signals and protein kinase C activation are higher in CD45R0+ than in CD45RA+ human T lymphocyte subsets
Robinson, A. T., Miller, N. G. A., & Alexander, D. R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230111 · Cited by 56
Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo.
McCormack, J. E., Kappler, J. W., & Marrack, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2086 · Cited by 54
The differentiation of human memory B cells into specific antibody‐secreting cells is CD40 independent
Silvy, A., Lagresle‐Peyrou, C., Bella, C., et al. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260303 · Cited by 53
Age-related changes in surface antigens on peripheral lymphocytes of healthy children
Osugi, Y., Hara, J., Kurahashi, H., Sakata, N., INOUE, M., Yumura‐Yagi, K., Kawa‐Ha, K., Okada, S., & Tawa, A. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03735.x · Cited by 52
Enumeration and Characterization of Memory Cells in the TH Compartment
McHeyzer‐Williams, M. G., Altman, J. D., & Davis, M. M. (1996) · Immunological Reviews · doi:10.1111/j.1600-065x.1996.tb00693.x · Cited by 52
Cellular Interactions in the Germinal Center: Role of Adhesion Receptors and Significance for the Pathogenesis of AIDS and Malignant Lymphoma
Koopman, G., & Pals, S. T. (1992) · Immunological Reviews · doi:10.1111/j.1600-065x.1992.tb00629.x · Cited by 52
Immunopathology of chronic lentivirus-induced arthritis.
Wilkerson, M. J., Davis, W. C., Baszler, T. V., & Cheevers, W. P. (1995) · PubMed · Cited by 50
A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis
Carpenter, S. M., Nunes-Alves, C., Booty, M. G., Way, S. S., & Behar, S. M. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005380 · Cited by 48
“These features, together with their long-lived nature and their ability to survey non-lymphoid organs allow memory T cells to quickly respond to acute infection [1–5].”
Stimulation of memory T cells by cytokines
Tough, D. F., Sun, S., Zhang, X. M., & Sprent, J. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00500-9 · Cited by 49
Immune responses of systemic and mucosal lymphoid organs to Pnu-Imune vaccine as a function of age and the efficacy of monophosphoryl lipid A as an adjuvant
Garg, M., & Subbarao, B. (1992) · Infection and Immunity · doi:10.1128/iai.60.6.2329-2336.1992 · Cited by 49
Differential expression of type I insulin‐like growth factor receptors in different stages of human T cells
Kooijman, R., Scholtens, L. E., Rijkers, G. T., et al. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250411 · Cited by 48
Differential responses of human B‐lymphocyte subpopulations to graded levels of CD40–CD154 interaction
Néron, S., Racine, C., Roy, A., et al. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02244.x · Cited by 47
Relative lymphocyte count as an indicator of 3-year mortality in elderly people with severe COPD
Acanfora, D., Scicchitano, P., Carone, M., et al. (2018) · BMC Pulmonary Medicine · doi:10.1186/s12890-018-0685-6 · Cited by 45
“As B cells can switch immunoglobulins among the different types and in agreement with specific actions toward the pathogenic agents, the reduction in B cell count can negatively affect outcome in elderly patients [29, 30].”
Background
Life-spans of human T-cell responses to determinants from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium vivax.
Zevering, Y., Khamboonruang, C., Rungruengthanakit, K., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6118 · Cited by 45
Demonstration of virus-specific CD8+ memory T cells in measles-seropositive individuals by in vitro peptide stimulation
Nanan, R. K. H., Carstens, C., & Kreth, H. W. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb06633.x · Cited by 44
Visualizing Memory Phenotype Development afterin VitroStimulation of CD4+T Cells
Lee, W. T., & Pelletier, W. J. (1998) · Cellular Immunology · doi:10.1006/cimm.1998.1341 · Cited by 42
Self-citation
T-cell activation influences initial DNA synthesis of simian immunodeficiency virus in resting T lymphocytes from macaques
Polacino, P. S., Liang, H. A., Firpo, E. J., & Clark, E. A. (1993) · Journal of Virology · doi:10.1128/jvi.67.12.7008-7016.1993 · Cited by 38
Integrated Defense System Overlaps as a Disease Model: With Examples for Multiple Chemical Sensitivity
Rowat, S. C. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s185 · Cited by 42
Thyroid-Infiltrating B Lymphocytes in Graves' Disease are Related to Marginal Zone and Memory B Cell Compartments
Segundo, C., Rodriguez, C. S., García-Poley, A., Aguilar‐Diosdado, M., Gavilán, I., Bellas, C., & Brieva, J. A. (2001) · Thyroid · doi:10.1089/105072501750302813 · Cited by 37
“The fact that about one-third of Thy-B lymphocytes bear surface IgG, an isotype only expressed after IgH gene switching, necessarily relates this cell fraction to the memory B cell compartment (22).”
Heterogeneity in P‐glycoprotein (multidrug resistance) activity among murine peripheral T cells: Correlation with surface phenotype and effector function
Bommhardt, U., Cerottini, J., & MacDonald, H. R. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241208 · Cited by 32
Memory in idiotypic networks due to competition between proliferation and differentiation
Sulzer, B., van Hemmen, J. L., Neumann, A. U., et al. (1993) · Bulletin of Mathematical Biology · doi:10.1007/bf02460702 · Cited by 29
Immune Network: An Example of Complex Adaptive Systems
Chowdhury, D. (1999) · Springer eBooks · doi:10.1007/978-3-642-59901-9_5 · Cited by 29
Changes in peripheral blood lymphocyte subsets in elderly subjects are associated with an impaired function of the hypothalamic–pituitary–adrenal axis
Martínez-Taboada, V. M., Bartolomé, M. J., Amado, J., Blanco, R., García‐Unzueta, M. T., Rodrı́guez-Valverde, V., & López‐Hoyos, M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00116-1 · Cited by 29
On the use of combinatorial antibody libraries to clone the "fossil record" of an individual's immune response.
Lerner, R. A., Barbas, C. F., Kang, A. S., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9705 · Cited by 28
Immunological Approach in the Evaluation of Regional Lymph Nodes of Patients with Squamous Cell Carcinoma of the Head and Neck
Verástegui, E., Morales‐Bárcenas, R., Barrera, J. L., et al. (2002) · Clinical Immunology · doi:10.1006/clim.2001.5130 · Cited by 27
Clinical use of allogeneic hematopoietic stem cells from sources other than bone marrow.
Arcese, W., Aversa, F., Bandini, G., et al. (1998) · PubMed · Cited by 27
Memory Cells in Infection and Autoimmunity: Mechanisms, Functions, and Therapeutic Implications
Giri, S., & Batra, L. (2025) · Vaccines · doi:10.3390/vaccines13020205 · Cited by 27
“These specialized cells, derived from prior immune responses, retain the capacity to mount rapid and robust responses upon re-exposure to antigens [1].”
Effects of dietary ω3 and ω6 lipids and vitamin E on proliferative response, lymphoid cell subsets, production of cytokines by spleen cells, and splenic protein levels for cytokines and oncogenes in MRL/MpJ-lpr/lpr mice11This research was funded by National Institute of Arthritis and Musculoskeletal and Skin Disorders grant IR15AR/AI43517.
Venkatraman, J. T., & Chu, W.-C. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00046-7 · Cited by 26
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Ganusov, V. V., & Antia, R. (2006) · Evolution · doi:10.1554/05-504.1 · Cited by 26
“Mathematical derivations and some additional results are summarized in the Appendix available online only at http://dx.doi.org/10.1554/05-504.1. s1.”
BackgroundInfluential
Somatic hypermutation of TCR γ V genes in the sandbar shark
Chen, H., Bernstein, H., Ranganathan, P., & Schluter, S. F. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.08.018 · Cited by 27
Gamma delta T cells differentiate into a functional but nonproliferative state during a normal immune response.
Spaner, D., Migita, K., Ochi, A., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8415 · Cited by 25
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Marelli‐Berg, F. M. (2012) · Frontiers in bioscience · doi:10.2741/4111 · Cited by 30
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Self-citation
Monoclonal Antibodies against the CεmX Domain of Human Membrane-Bound IgE and Their Potential Use for Targeting IgE-Expressing B Cells
Chen, H. Y., Liu, F., Hou, C. M. H., et al. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000063860 · Cited by 22
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López‐Hoyos, M., Bartolome-Pacheco, M. J., Blanco, R., Rodriguez-Valverde, V., & Martinez-Taboada, V. M. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.005900 · Cited by 22
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Self-citation
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Wienands, J., & Engels, N. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_480 · Cited by 23
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FIRPO, P. P., Axberg, I., Scheibel, M., & Clark, E. A. (1992) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1992.8.357 · Cited by 20

Authors: Vitetta, E. S., Berton, M. T., Burger, C., Kepron, M., Lee, W. T., & Yin, X. M.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Lee, W T
Yin, X M
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 1991-04
Volume: 9
Issue: 1
Pages: 193-217
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.iy.09.040191.001205
OpenAlex: W2025036070
Cited by: 187
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 3
FWCI: 7.47
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai021229-05, 5f32ai007959-02, 2p01ai011851-16)
National Institute of Allergy and Infectious Diseases (AI-07959, AI-21229, AI11851)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: memory B cells, memory T cells, immunological memory, secondary antibody response, B cell receptor, T cell receptor, affinity maturation, lymphokines, adhesion molecules, T cell activation, B cell activation
MeSH terms: Animals, Antibody Affinity, Antigens, Differentiation, B-Lymphocytes, Cell Survival, Humans, Immunologic Memory, T-Lymphocytes

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