The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
The Role of the CD28 Receptor During T Cell Responses to Antigen
Abstract
The CD28 receptor is stimulated during the contact of T cells with antigen-presenting cells. A counter-receptor for CD28 is the B7 molecule expressed on activated B cells, dendritic cells, and macrophages. B7 also binds to CTLA-4, a receptor that is structurally related to CD28. CTLA-4 is expressed in low copy number by T cells only after activation, but it binds B7 with approximately 20-fold higher affinity than CD28. Inhibition of B7-CD28 interactions blocks immune responses in vitro and in vivo. Therefore, CD28 receptor stimulation is required for T cell responses to antigens and for B cell responses to T-dependent antigens. During T cell responses to antigens, CD28 receptor stimulation may be required to prevent clonal inactivation or anergy. CD28 receptor ligation induces tyrosine phosphorylation of specific substrates, including phospholipase C gamma 1, and triggers both calcium-dependent and calcium-independent signals. The CD28 costimulatory receptor represents a novel target for immunosuppressive drugs.
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Cites
The Immunoglobulin Superfamily: Domains For Cell Surface Recognition
Williams, A. (1988) · Annual Review of Immunology · doi:10.1146/annurev.immunol.6.1.381 · Cited by 2,254
CTLA-4 is a second receptor for the B cell activation antigen B7.
Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.3.561 · Cited by 1,685
Self-citationIdentification of calcineurin as a key signalling enzyme in T-lymphocyte activation
Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,637
Harding, F. A., McArthur, J. G., Gross, J. A., Raulet, D. H., & Allison, J. P. (1992) · Nature · doi:10.1038/356607a0 · Cited by 1,559
Linsley, P. S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.3.721 · Cited by 1,127
Self-citationRegulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway
Lindstein, T., June, C. H., Ledbetter, J. A., Stella, G., & Thompson, C. B. (1989) · Science · doi:10.1126/science.2540528 · Cited by 878
Self-citationFK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
O'Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., & O'Neill, E. A. (1992) · Nature · doi:10.1038/357692a0 · Cited by 841
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
Fruman, D. A., Klee, C. B., Bierer, B. E., & Burakoff, S. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3686 · Cited by 823
Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule
Linsley, P. S., Wallace, P. M., Johnson, J., Gibson, M. G., Greene, J. L., Ledbetter, J. A., Singh, C., & Tepper, M. A. (1992) · Science · doi:10.1126/science.1496399 · Cited by 790
Self-citationRole of the CD28 receptor in T-cell activation
June, C. H., Ledbetter, J. A., Linsley, P. S., & Thompson, C. B. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90085-n · Cited by 676
Self-citation
Cited by
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Enhancement of Antitumor Immunity by CTLA-4 Blockade
Leach, D. R., Krummel, M. F., & Allison, J. P. (1996) · Science · doi:10.1126/science.271.5256.1734 · Cited by 3,955
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H., & Mak, T. W. (1995) · Science · doi:10.1126/science.270.5238.985 · Cited by 2,766
CD28/B7 SYSTEM OF T CELL COSTIMULATION
Lenschow, D. J., Walunas, T. L., & Bluestone, J. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.233 · Cited by 2,717
Metadata
- Authors
- Linsley, P. S., & Ledbetter, J. A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1993-04
- Volume
- 11
- Issue
- 1
- Pages
- 191-212
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2172960056
- Cited by
- 1,298
- References
- 54
- FWCI
- 43.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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