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Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway
Abstract
Quiescent T cells can be induced to express many genes by mitogen or antigen stimulation. The messenger RNAs of some of these genes undergo relatively rapid degradation compared to messenger RNAs from constitutively expressed genes. A T cell activation pathway that specifically regulates the stability of messenger RNAs for the lymphokines interleukin-2, interferon-γ, tumor necrosis factor-α, and granulocyte-macrophage colony-stimulating factor is induced by stimulation of the CD28 surface molecule. This pathway does not directly affect the steady-state messenger RNA level, transcription, or messenger RNA half-life of other T cell activation genes, including c- myc , c- fos , IL-2 receptor, and the 4F2HC surface antigen. These data show that stimuli received at the cell surface can alter gene expression by inducing specific changes in messenger RNA degradation.
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Cited by
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,603
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
Krummel, M. F., & Allison, J. P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.2.459 · Cited by 2,245
AU-rich elements: characterization and importance in mRNA degradation
Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948
A cell culture model for T lymphocyte clonal anergy
Schwartz, R. H. (1990) · Science · doi:10.1126/science.2113314 · Cited by 1,857
CTLA-4 is a second receptor for the B cell activation antigen B7.
Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.3.561 · Cited by 1,685
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Metadata
- Authors
- Lindstein, T., June, C. H., Ledbetter, J. A., Stella, G., & Thompson, C. B.
- Venue
- Science
- Published
- 1989-04-21
- Volume
- 244
- Issue
- 4902
- Pages
- 339-343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993210315
- Cited by
- 878
- References
- 0
- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lindstein, T., June, C. H., Ledbetter, J. A., Stella, G., & Thompson, C. B. (1989). Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway. Science. https://doi.org/10.1126/science.2540528
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