The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Serum Transferrin Receptor
Abstract
The transferrin receptor plays a critical role in iron metabolism by precisely contrOlling the flow of transferrin iron into body cells. A soluble truncated form of the receptor can be detected in human serum using sensitive immunoassays, and the initial clinical experience with this new measurement indicates that it reflects the total body mass of tissue receptor. Serum receptor levels rise significantly with tissue iron deficiency and the heightened demand for iron associated with expansion of the erythroid marrow. The serum receptor provides a quantitative measure of functional iron deficiency and distinguishes the associated anemia from that of chronic disease. If iron deficiency is excluded, the serum receptor provides a quantitative measure of total erythropoiesis that is more sensitive and less invasive than bone marrow examination currently used to assess red cell precursor mass. Performed in conjunction with serum ferritin measurements, the serum receptor will be useful in establishing the true prevalence of iron deficiency anemia in population studies.
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Cites
Intact transferrin receptors in human plasma and their relation to erythropoiesis
Huebers, H., Beguin, Y., Pootrakul, P., Einspahr, D., & Finch, C. (1990) · Blood · doi:10.1182/blood.v75.1.102.102 · Cited by 364
Cited by
Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency
Punnonen, K., Irjala, K., & Rajamäki, A. (1997) · Blood · doi:10.1182/blood.v89.3.1052 · Cited by 859
Kell, D. B., & Pretorius, E. (2014) · Metallomics · doi:10.1039/c3mt00347g · Cited by 667
Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
Jankowska, E. A., von Haehling, S., Anker, S. D., Macdougall, I. C., & Ponikowski, P. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs224 · Cited by 399
Diagnosis of iron-deficient states
Archer, N. M., & Brugnara, C. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1038744 · Cited by 82
Weight loss, inflammatory markers, and improvements of iron status in overweight and obese children
Gong, L., Yuan, F., Teng, J., Li, X., Zheng, S., Lin, L., Deng, H., Ma, G., Sun, C., & Li, Y. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.12.004 · Cited by 51
Metadata
- Authors
- Cook, J. D., Skikne, B. S., & Baynes, R. D.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1993-02
- Volume
- 44
- Issue
- 1
- Pages
- 63-74
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2131310817
- Cited by
- 379
- References
- 1
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
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