Intact transferrin receptors in human plasma and their relation to erythropoiesis
Open accessAbstract
Intact transferrin receptor molecules complexed with transferrin were found in human plasma. The concentration of receptors was determined by an enzyme-linked immunosorbent assay that uses polyclonal antibodies. The mean concentration of 8,279 micrograms/L in 56 normal adults appears to be unrelated to age or sex. Additional receptor measurements were performed on plasmas from 260 subjects with erythropoietic disorders. Decreased concentration of plasma receptors was found in patients with erythroid hypoplasia and increased numbers in those with erythroid hyperplasia. Ferrokinetic measurements of erythropoiesis were compared with numbers of receptors in 148 subjects, and a close correlation was found (r = .86). Both sets of values, measured in different conditions and expressed in relation to normal, were consistent with expected values. Receptor values were unproportionally increased only in conditions of iron deficiency. It is concluded that plasma receptors have a constant relationship to tissue receptors, and their number in most instances reflects the rate of erythropoiesis.
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Chuvash polycythemia due to homozygosity for VHL R200W has EPO levels often in normal range but inappropriately increased in context of polycythemia.
“These observations are similar to those reported in Chuvash polycythemia due to homozygosity for VhL R200W , in which EPO levels are often in the normal range but inappropriately increased in the context of polycythemia (24).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [24]
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- Authors
- Huebers, H., Beguin, Y., Pootrakul, P., Einspahr, D., & Finch, C.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1990-01-01
- Volume
- 75
- Issue
- 1
- Pages
- 102-107
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1579613226
- Cited by
- 364
- References
- 21
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Funders
- U.S. Department of Agriculture
- Texas Children's Hospital
- International Atomic Energy Agency
- National Institutes of Health (1f05tw003784-01)
- Agricultural Research Service
- National Heart, Lung, and Blood Institute (HL-06242)
- Fogarty International Center (1 FO5 TWO3784-01 BI-5)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- transferrin receptor, erythropoiesis, erythroid hypoplasia, erythroid hyperplasia, iron deficiency, polyclonal antibodies
- MeSH terms
- Erythropoiesis, Hematologic Diseases, Humans, Iron, Receptors, Transferrin, Transferrin
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