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Cited by 379

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Serum Transferrin Receptor

Cook, J. D., Skikne, B. S., Baynes, R. D.·1993·Annual Review of Medicine

Abstract

The transferrin receptor plays a critical role in iron metabolism by precisely contrOlling the flow of transferrin iron into body cells. A soluble truncated form of the receptor can be detected in human serum using sensitive immunoassays, and the initial clinical experience with this new measurement indicates that it reflects the total body mass of tissue receptor. Serum receptor levels rise significantly with tissue iron deficiency and the heightened demand for iron associated with expansion of the erythroid marrow. The serum receptor provides a quantitative measure of functional iron deficiency and distinguishes the associated anemia from that of chronic disease. If iron deficiency is excluded, the serum receptor provides a quantitative measure of total erythropoiesis that is more sensitive and less invasive than bone marrow examination currently used to assess red cell precursor mass. Performed in conjunction with serum ferritin measurements, the serum receptor will be useful in establishing the true prevalence of iron deficiency anemia in population studies.

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Crossref · 10.1146/annurev.me.44.020193.000431

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Metadata

Authors
Cook, J. D., Skikne, B. S., & Baynes, R. D.
Venue
Annual Review of Medicine
Published
1993-02
Volume
44
Issue
1
Pages
63-74
ISSN
  • 0066-4219 (ISSN-L)
  • 1545-326X
OpenAlex
W2131310817
Cited by
379
References
1
FWCI
4.77
Type
journal article
Language
en
Open access
closed

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