The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
ORGAN PRESERVATION
Abstract
▪ Abstract Organ preservation is the supply line for organ transplantation. Currently, the liver, pancreas, and kidney can be successfully preserved for up to two days by flushing the organs with the University of Wisconsin (UW) organ preservation solution and storing them at hypothermia (0–5° C). The UW solution is effective because it uses a number of cell impermeant agents (lactobionic acid, raffinose, hydroxyethyl starch) that prevent the cells from swelling during cold ischemic storage. Additionally, the UW solution contains glutathione and adenosine, agents that may stimulate recovery of normal metabolism upon reperfusion by augmenting the antioxidant capacity of the organs (glutathione) or by stimulating high-energy phosphate generation (adenosine) upon reperfusion. Although this method of organ preservation is effective, some organs (5–15% of livers and 20–30% of kidneys) do not function well upon transplant. Injury may be preservation related but may also result from donor and recipient factors that render the organs more susceptible to preservation damage. Results with continuous perfusion of kidneys in the clinics show a reduction in preservation/reperfusion damage. This may be a more appropriate preservation method than cold storage. In this chapter we discuss the development and use of the UW solution and present clinical results. Although intraabdominal organs are well preserved at present, intrathoracic organs (lungs and heart) are less well preserved, and better methods for preservation of these organs are needed for increased use of lung and heart transplantation.
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Cites
RISK FACTORS FOR PRIMARY DYSFUNCTION AFTER LIVER TRANSPLANTATION—A MULTIVARIATE ANALYSIS
PLOEG, R. J., DʼALESSANDRO, A. M., KNECHTLE, S. J., STEGALL, M. D., PIRSCH, J. D., HOFFMANN, R. M., SASAKI, T., SOLLINGER, H. W., BELZER, F. O., & KALAYOGLU, M. (1993) · Transplantation · doi:10.1097/00007890-199304000-00024 · Cited by 1,026
PRESERVATION AND REPERFUSION INJURIES IN LIVER ALLOGRAFTS
Clavien, P.-A., Harvey, P. R., & Strasberg, S. M. (1992) · Transplantation · doi:10.1097/00007890-199205000-00001 · Cited by 829
KIDNEY PRESERVATION FOR TRANSPORTATION
Collins, G. M., Bravo-Shugarman, M., & Terasaki, P. I. (1969) · The Lancet · doi:10.1016/s0140-6736(69)90753-3 · Cited by 731
24-HOUR AND 72-HOUR PRESERVATION OF CANINE KIDNEYS
Belzer, F., Ashby, B. S., & Dunphy, J. E. (1967) · The Lancet · doi:10.1016/s0140-6736(67)90498-9 · Cited by 463
EXTENDED PRESERVATION OF THE LIVER FOR CLINICAL TRANSPLANTATION
Yoglu, M., Stratta, R., Hoffmann, R., Sollinger, H., D'Alessandro, A., Pirsch, J., & Belzer, F. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91416-x · Cited by 376
Effect of preservation solution on results of cadaveric kidney transplantation
Ploeg, R. J., van Bockel, J. H., Langendijk, P. T. H., Groenewegen, M., van der Woude, F. J., Persijn, G. G., Thorogood, J., & Hermans, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)93212-6 · Cited by 232
SUCCESSFUL 72-HOUR COLD STORAGE OF DOG KIDNEYS WITH UW SOLUTION
PLOEG, R. J., GOOSSENS, D., MCANULTY, J. F., SOUTHARD, J. H., & BELZER, F. O. (1988) · Transplantation · doi:10.1097/00007890-198808000-00002 · Cited by 177
ERHARD, J., Länge, R., Scherer, R. U., Kox, W. J., Bretschneider, H. J., Gebhard, M. M., & Eigler, F. W. (1994) · Transplant International · doi:10.1007/bf00327084 · Cited by 150
SEVENTY-TWO-HOUR PRESERVATION OF THE CANINE LIVER BY MACHINE PERFUSION
Pienaar, B., Lindell, S. L., van Gulik, T. M., Southard, J. H., & Belzer, F. O. (1990) · Transplantation · doi:10.1097/00007890-199002000-00005 · Cited by 122
ADVANTAGE OF COLD STORAGE OVER MACHINE PERFUSION FOR PRESERVATION OF CADAVER KIDNEYS
Opelz, G., & Terasaki, P. I. (1982) · Transplantation · doi:10.1097/00007890-198201000-00013 · Cited by 88
Cited by
Technique for Prolonged Normothermic Ex Vivo Lung Perfusion
Cypel, M., Yeung, J. C., Hirayama, S., Rubacha, M., Fischer, S., Anraku, M., Sato, M., Harwood, S., Pierre, A., Waddell, T. K., et al. (2008) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2008.09.003 · Cited by 537
Lactose: Crystallization, hydrolysis and value-added derivatives
Gänzle, M. G., Haase, G., & Jelen, P. (2008) · International Dairy Journal · doi:10.1016/j.idairyj.2008.03.003 · Cited by 296
Cryopreservation of Whole Murine and Porcine Livers
Gavish, Z., Ben-Haim, M., & Arav, A. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0706 · Cited by 68
Feeding strategies for enhanced lactobionic acid production from whey by Pseudomonas taetrolens
Alonso, S., Rendueles, M., & Díaz, M. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.01.145 · Cited by 48
Messner, F., Guo, Y., Etra, J. W., & Brandacher, G. (2019) · Transplant International · doi:10.1111/tri.13432 · Cited by 29
Metadata
- Authors
- Southard, M. D., & Belzer, M. D.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1995-02
- Volume
- 46
- Issue
- 1
- Pages
- 235-247
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W4238198470
- Cited by
- 404
- References
- 12
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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