Cited by 29Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchOrgan Transplantation Techniques and Outcomes

Emerging Technologies in Organ Preservation, Tissue Engineering and Regenerative Medicine: A Blessing or Curse for Transplantation?

Messner, Franka, Guo, Yinan, Etra, Joanna W., Brandacher, Gerald·2019·Transplant International

Abstract

Since the beginning of transplant medicine in the 1950s, advances in surgical technique and immunosuppressive therapy have created the success story of modern organ transplantation. However, today more than ever, we are facing a huge discrepancy between organ supply and demand, limiting the potential for transplantation to save and improve the lives of millions. To address the current limitations and shortcomings, a variety of emerging new technologies focusing on either maximizing the availability of organs or on generating new organs and organ sources hold great potential to eventully overcoming these hurdles. These advances are mainly in the field of regenerative medicine and tissue engineering. This review gives an overview of this emerging field and its multiple sub-disciplines and highlights recent advances and existing limitations for widespread clinical application and potential impact on the future of transplantation.

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Registry

Crossref · 10.1111/tri.13432

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158 of 158 references verified0 citation errors · 0 not checkable

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  • The allocation process depends on the timeframe during which the organ remains viable once harvested, which ranges from a few to 36 h, depending on the organ.

    “Additionally, the allocation (and donor-recipient matching) process depends on the timeframe during which the organ remains viable once harvested, which ranges from a few to 36 h, depending on the organ (5).”

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Authors
Messner, F., Guo, Y., Etra, J. W., & Brandacher, G.
Affiliations
  • Innsbruck Medical University (AT)
  • Central South University (CN)
  • Johns Hopkins University (US)
Venue
Transplant International
Published
2019-04-11
Volume
32
Issue
7
Pages
673-685
ISSN
  • 0934-0874 (ISSN-L)
  • 1432-2277
OpenAlex
W2932786429
Cited by
29
References
158
Citations by year
2025: 2 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 7
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Locations
  • Transplant International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
organ preservation, tissue engineering, regenerative medicine, organ transplantation, organ supply and demand, organ shortage, organ availability, organ regeneration, clinical translation
MeSH terms
Animals, Humans, Immunosuppression Therapy, Organ Preservation, Tissue and Organ Procurement, Perfusion, Transplantation, Transplantation, Heterologous, Cryopreservation, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds, Bioprinting, Printing, Three-Dimensional

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