Emerging Technologies in Organ Preservation, Tissue Engineering and Regenerative Medicine: A Blessing or Curse for Transplantation?
Abstract
Since the beginning of transplant medicine in the 1950s, advances in surgical technique and immunosuppressive therapy have created the success story of modern organ transplantation. However, today more than ever, we are facing a huge discrepancy between organ supply and demand, limiting the potential for transplantation to save and improve the lives of millions. To address the current limitations and shortcomings, a variety of emerging new technologies focusing on either maximizing the availability of organs or on generating new organs and organ sources hold great potential to eventully overcoming these hurdles. These advances are mainly in the field of regenerative medicine and tissue engineering. This review gives an overview of this emerging field and its multiple sub-disciplines and highlights recent advances and existing limitations for widespread clinical application and potential impact on the future of transplantation.
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The allocation process depends on the timeframe during which the organ remains viable once harvested, which ranges from a few to 36 h, depending on the organ.
“Additionally, the allocation (and donor-recipient matching) process depends on the timeframe during which the organ remains viable once harvested, which ranges from a few to 36 h, depending on the organ (5).”
From Artificial Intelligence: Present and Future Potential for Solid Organ Transplantation (2022) · cites this paper as [5]
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Artificial Intelligence: Present and Future Potential for Solid Organ Transplantation
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- Authors
- Messner, F., Guo, Y., Etra, J. W., & Brandacher, G.
- Affiliations
- Innsbruck Medical University (AT)
- Central South University (CN)
- Johns Hopkins University (US)
- Venue
- Transplant International
- Publisher
- Frontiers Media SA
- Published
- 2019-04-11
- Volume
- 32
- Issue
- 7
- Pages
- 673-685
- ISSN
- 0934-0874 (ISSN-L)
- 1432-2277
- OpenAlex
- W2932786429
- Cited by
- 29
- References
- 158
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 7
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Transplant International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- organ preservation, tissue engineering, regenerative medicine, organ transplantation, organ supply and demand, organ shortage, organ availability, organ regeneration, clinical translation
- MeSH terms
- Animals, Humans, Immunosuppression Therapy, Organ Preservation, Tissue and Organ Procurement, Perfusion, Transplantation, Transplantation, Heterologous, Cryopreservation, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds, Bioprinting, Printing, Three-Dimensional
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