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Cited by 466

The DOI matches its Crossref record.

The Ubiquitin-Proteasome Pathway and Pathogenesis of Human Diseases

Schwartz, PhD, MD, Alan L., Ciechanover, MD, PhD, Aaron·1999·Annual Review of Medicine
DOI 10.1146/annurev.med.50.1.57
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Abstract

The ubiquitin-proteasome pathway plays a pivotal role in the degradation of short-lived and regulatory proteins important in a variety of basic cellular processes, including regulation of the cell cycle, modulation of cell surface receptors and ion channels, and antigen presentation. The pathway involves an enzymatic cascade through which multiple ubiquitin molecules are covalently attached to the protein substrate, which is then degraded by the 26S proteasome complex. The pathway has been implicated in several forms of malignancy, in the pathogenesis of several genetic diseases (including cystic fibrosis, Angelman's syndroome, and Liddle syndrome), in immune surveillance/viral pathogenesis, and in the pathology of muscle wasting. The molecular mechanisms that underlie these processes are being unraveled at present.

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Metadata

Authors
Schwartz, P., & Ciechanover, M.
Venue
Annual Review of Medicine
Publisher
Annual Reviews
Published
1999-02
Volume
50
Issue
1
Pages
57-74
ISSN
  • 0066-4219 (ISSN-L)
  • 1545-326X
DOI
10.1146/annurev.med.50.1.57
OpenAlex
W2111524632
Cited by
466
References
0
FWCI
1.85
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.