The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Mechanisms of Pulmonary Fibrosis
Abstract
Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less well-understood host repair responses. Both inflammation and repair involve the recruitment, activation, apoptosis, and eventual clearance of key effector cells. In this review, we propose the concept of pulmonary fibrosis as a dysregulated repair process that is perpetually “turned on” even though classical inflammatory pathways may be dampened or “switched off.” Significant regional heterogeneity, with varied histopathological patterns of inflammation and fibrosis, has been observed in individual patients with idiopathic pulmonary fibrosis. We discuss environmental factors and host response factors, such as genetic susceptibility and age, that may influence these varied manifestations. Better understanding of the mechanisms of lung repair, which include alveolar reepithelialization, myofibroblast differentiation/activation, and apoptosis, should offer more effective therapeutic options for progressive pulmonary fibrosis.
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Cites
Multilineage potential of adult human mesenchymal stem cells
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Myofibroblasts and mechano-regulation of connective tissue remodelling
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How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
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Self-citation
Cited by
Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Hinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068
Self-citationFormation and function of the myofibroblast during tissue repair
Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658
Fibrosis–a common pathway to organ injury and failure
Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346
Metadata
- Authors
- Thannickal, V. J., Toews, G. B., White, E. S., Lynch III, J. P., & Martinez, F. J.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2004-02-01
- Volume
- 55
- Issue
- 1
- Pages
- 395-417
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2157977329
- Cited by
- 808
- References
- 14
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thannickal, V. J., Toews, G. B., White, E. S., Lynch III, J. P., & Martinez, F. J. (2004). Mechanisms of Pulmonary Fibrosis. Annual Review of Medicine. https://doi.org/10.1146/annurev.med.55.091902.103810
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
