The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Cancer Stem Cells: Models and Concepts
Abstract
Although monoclonal in origin, most tumors appear to contain a heterogeneous population of cancer cells. This observation is traditionally explained by postulating variations in tumor microenvironment and coexistence of multiple genetic subclones, created by progressive and divergent accumulation of independent somatic mutations. An additional explanation, however, envisages human tumors not as mere monoclonal expansions of transformed cells, but rather as complex tridimensional tissues where cancer cells become functionally heterogeneous as a result of differentiation. According to this second scenario, tumors act as caricatures of their corresponding normal tissues and are sustained in their growth by a pathological counterpart of normal adult stem cells, cancer stem cells. This model, first developed in human myeloid leukemias, is today being extended to solid tumors, such as breast and brain cancer. We review the biological basis and the therapeutic implications of the stem cell model of cancer.
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Cites
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Self-citationGranulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
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“Most interestingly, when compared to their normal counterparts, GMPs from BcCML show aberrant de novo acquisition of in vitro self-renewal properties, associated with increased nuclear expression of β-catenin (30).”
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Cited by
Metabolic requirements for the maintenance of self-renewing stem cells
Ito, K., & Suda, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3772 · Cited by 1,014
Alcantara Llaguno, S., Chen, J., Kwon, C.-H., Jackson, E. L., Li, Y., Burns, D. K., Alvarez-Buylla, A., & Parada, L. F. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.006 · Cited by 694
Understanding and targeting cancer stem cells: therapeutic implications and challenges
Chen, K., Huang, Y.-H., & Chen, J.-L. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.27 · Cited by 608
Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
Cobaleda, C., Jochum, W., & Busslinger, M. (2007) · Nature · doi:10.1038/nature06159 · Cited by 502
Gunaydin, G., Gedik, M. E., & Ayan, S. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.686303 · Cited by 402
Metadata
- Authors
- Dalerba, P., Cho, R. W., & Clarke, M. F.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2007-02-01
- Volume
- 58
- Issue
- 1
- Pages
- 267-284
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2134987819
- Cited by
- 1,274
- References
- 11
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dalerba, P., Cho, R. W., & Clarke, M. F. (2007). Cancer Stem Cells: Models and Concepts. Annual Review of Medicine. https://doi.org/10.1146/annurev.med.58.062105.204854
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
