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Cited by 1,014Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and MetabolismMesenchymal stem cell research

Metabolic requirements for the maintenance of self-renewing stem cells

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Ito, Keisuke, Suda, Toshio·2014·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3772PMC PMC4095859
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Abstract

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency. Studies of genetically-engineered mouse models and recent advances in metabolomic analysis, particularly in haematopoietic stem cells, have deepened our understanding of the contribution made by metabolic cues to the regulation of stem cell self-renewal. Many types of stem cells heavily rely on anaerobic glycolysis, and stem cell function is also regulated by bioenergetic signalling, the AKT-mTOR pathway, Gln metabolism and fatty acid metabolism. As maintenance of a stem cell pool requires a finely-tuned balance between self-renewal and differentiation, investigations into the molecular mechanisms and metabolic pathways underlying these decisions hold great therapeutic promise.

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  • An increase in ROS, as encountered in spaceflight, triggers adult stem cell differentiation and rapidly switches to mitochondrial OXPHOS.

    “An increase in ROS, as encountered in spaceflight, triggers adult stem cells differentiation, and rapidly switches to mitochondrial OXPHOS (Hamanaka et al., 2013; Ito and Suda, 2014).”

    From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Ito and Suda, 2014

    The sections “Glycolysis and HIF in other adult stem cells” and “Switch to oxidative metabolism” say that ROS induced under normoxia can move adult stem cells out of quiescence and may prime differentiation, while differentiating HSCs need a rapid switch to mitochondrial OXPHOS. They do not establish that increased ROS directly triggers that switch or differentiation, and they do not address spaceflight. The copy provides section labels but no page numbers. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Authors
Ito, K., & Suda, T.
Affiliations
  • Albert Einstein College of Medicine (US)
  • Keio University (JP)
Corresponding author
  • Ito, Keisuke
  • Suda, Toshio
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2014-03-21
Volume
15
Issue
4
Pages
243-256
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm3772
PMC
PMC4095859
OpenAlex
W2009397177
Cited by
1,014
References
31
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FWCI
15.00
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • European Commission
  • Japan Society for the Promotion of Science (26221309)
  • National Cancer Institute (K99CA139009, R00CA139009)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK98263, R01DK100689, R01DK098263)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
stem cell self-renewal, stem cell metabolism, hematopoietic stem cells, anaerobic glycolysis, Akt/mTOR signaling, glutamine metabolism, fatty acid metabolism, stem cell differentiation, pluripotency
MeSH terms
Animals, Cell Differentiation, Energy Metabolism, Humans, Stem Cells, Signal Transduction, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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