The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antiretroviral Drug–Based Microbicides to Prevent HIV-1 Sexual Transmission
Abstract
The development of a vaginal (and perhaps a rectal) microbicide would be of major benefit for slowing the global spread of human immunodeficiency virus type 1 (HIV-1). A microbicide is a gel or related device that, when inserted vaginally or rectally, acts to prevent infection of a woman or a man by HIV-1 during sexual intercourse. A practical microbicide must be not only effective, safe, and user-friendly but also economically affordable in the developing world. To date, the performance of microbicide candidates in efficacy trials has been disappointing, but next-generation concepts now in or approaching clinical trials offer improved prospects for efficacy. The most plausible approaches involve topical application of antiretroviral agents with specific activity against HIV-1, compounds similar to drugs used to treat HIV-1 infection. How these inhibitors are applied may also be critical, with sustained-release formulations and vaginal ring delivery systems now becoming a high priority.
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Citations
Cites
HIV/AIDS in Women: An Expanding Epidemic
Quinn, T. C., & Overbaugh, J. (2005) · Science · doi:10.1126/science.1112489 · Cited by 417
Transmission, acute HIV-1 infection and the quest for strategies to prevent infection
Pope, M., & Haase, A. T. (2003) · Nature Medicine · doi:10.1038/nm0703-847 · Cited by 355
Target cells in vaginal HIV transmission
Miller, C. J., & Shattock, R. J. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(02)00056-4 · Cited by 220
Self-citation
Cited by
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Ghosh, T., Chattopadhyay, K., Marschall, M., Karmakar, P., Mandal, P., & Ray, B. (2009) · Glycobiology · doi:10.1093/glycob/cwn092 · Cited by 391
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Singh, R. K., Tiwari, S. P., Rai, A. K., & Mohapatra, T. M. (2011) · The Journal of Antibiotics · doi:10.1038/ja.2011.21 · Cited by 370
O'Keefe, B. R., Vojdani, F., Buffa, V., Shattock, R. J., Montefiori, D. C., Bakke, J., Mirsalis, J., d'Andrea, A.-L., Hume, S. D., Bratcher, B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901506106 · Cited by 262
Self-citationEmerging Nanotechnology Approaches for HIV/AIDS Treatment and Prevention
Mamo, T., Moseman, E. A., Kolishetti, N., Salvador-Morales, C., Shi, J., Kuritzkes, D. R., Langer, R., Andrian, U. V., & Farokhzad, O. C. (2010) · Nanomedicine · doi:10.2217/nnm.10.1 · Cited by 255
Metadata
- Authors
- Klasse, P. J., Shattock, R., & Moore, J. P.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2008-02-01
- Volume
- 59
- Issue
- 1
- Pages
- 455-471
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2160010002
- Cited by
- 178
- References
- 3
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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