Cited by 355HIV Research and TreatmentHIV/AIDS Research and InterventionsHIV/AIDS drug development and treatment

Transmission, acute HIV-1 infection and the quest for strategies to prevent infection

Pope, Melissa, Haase, Ashley T·2003·Nature Medicine

Abstract

By the acute stage of HIV-1 infection, the immune system already faces daunting challenges. Research on mucosal barriers and the events immediately after heterosexual transmission that precede this acute stage could facilitate the development of effective microbicides and vaccines.

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Crossref · 10.1038/nm0703-847

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91 of 91 references verified0 citation errors · 0 not checkable

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  • After binding to GalCer and crossing the epithelial barrier by transcytosis, R5-tropic HIV-1 is captured by subepithelial DCs and macrophages in a CD4-independent manner via alternative receptors; DCs migrate to lymph nodes where they infect T cells.

    “After binding to GalCer, and crossing the epithelial barrier by transcytosis, R5-tropic HIV-1 is captured by subepithelial DCs and macrophages in a CD4-independent manner via alternative receptors. The DCs then migrate to the lymph nodes, where they infect T cells [61].”

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Authors
Pope, M., & Haase, A. T.
Affiliations
  • Population Council (IN)
  • University of Minnesota (US)
Corresponding author
Haase, Ashley T
Venue
Nature Medicine
Published
2003-07-01
Volume
9
Issue
7
Pages
847-852
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W2012325453
Cited by
355
References
91
Citations by year
2025: 2 · 2024: 2 · 2023: 4 · 2022: 11 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 18 · 2013: 15 · 2012: 19
FWCI
4.08
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Minnesota
  • National Institutes of Health (5r21ai052060-02, 5p30ca079458-04, RR00167, AI52048, HD41752)
  • National Cancer Institute (CA 79458)
  • National Institute of Allergy and Infectious Diseases (AI 28246, AI 48484, R37AI028246, R01AI048484, AI-52060, AI52048, AI 40877, P01AI052048)
  • National Center for Research Resources (RR 00167, P51RR000167)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD041752, HD-41752, R01HD037356, HD 37356)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords
HIV-1 transmission, acute HIV-1 infection, heterosexual transmission, mucosal barrier, microbicides, HIV vaccine, HIV prevention, immune response to HIV
MeSH terms
Acute Disease, Animals, Female, Humans, Male, Menstrual Cycle, Mucous Membrane, Semen, Vagina, Simian Immunodeficiency Virus, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Simian Acquired Immunodeficiency Syndrome, AIDS Vaccines

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