Transmission, acute HIV-1 infection and the quest for strategies to prevent infection
Abstract
By the acute stage of HIV-1 infection, the immune system already faces daunting challenges. Research on mucosal barriers and the events immediately after heterosexual transmission that precede this acute stage could facilitate the development of effective microbicides and vaccines.
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After binding to GalCer and crossing the epithelial barrier by transcytosis, R5-tropic HIV-1 is captured by subepithelial DCs and macrophages in a CD4-independent manner via alternative receptors; DCs migrate to lymph nodes where they infect T cells.
“After binding to GalCer, and crossing the epithelial barrier by transcytosis, R5-tropic HIV-1 is captured by subepithelial DCs and macrophages in a CD4-independent manner via alternative receptors. The DCs then migrate to the lymph nodes, where they infect T cells [61].”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [61]
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- Authors
- Pope, M., & Haase, A. T.
- Affiliations
- Population Council (IN)
- University of Minnesota (US)
- Corresponding author
- Haase, Ashley T
- Venue
- Nature Medicine
- Published
- 2003-07-01
- Volume
- 9
- Issue
- 7
- Pages
- 847-852
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2012325453
- Cited by
- 355
- References
- 91
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 11 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 18 · 2013: 15 · 2012: 19
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Minnesota
- National Institutes of Health (5r21ai052060-02, 5p30ca079458-04, RR00167, AI52048, HD41752)
- National Cancer Institute (CA 79458)
- National Institute of Allergy and Infectious Diseases (AI 28246, AI 48484, R37AI028246, R01AI048484, AI-52060, AI52048, AI 40877, P01AI052048)
- National Center for Research Resources (RR 00167, P51RR000167)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD041752, HD-41752, R01HD037356, HD 37356)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- HIV-1 transmission, acute HIV-1 infection, heterosexual transmission, mucosal barrier, microbicides, HIV vaccine, HIV prevention, immune response to HIV
- MeSH terms
- Acute Disease, Animals, Female, Humans, Male, Menstrual Cycle, Mucous Membrane, Semen, Vagina, Simian Immunodeficiency Virus, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Simian Acquired Immunodeficiency Syndrome, AIDS Vaccines
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